Articles tagged "Graft function"

2015 American Transplant Congress
Mitochondrial Feedback Mechanisms in Kidney Cell Senescence
K. De Vusser,¹ K. Hochstenbach,² E. Winckelmans,² E. Lerut,³ D. Kuypers,¹ T. Nawrot,² M. Naesens.¹
¹Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium; ²Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium; ³Department of Pathology, University Hospitals Leuven, Leuven, Belgium.
BackgroundProgressive DNA damage (telomere attrition) is considered one of the key instigators of ageing. Different models for ageing where DNA damage leads to accelerated senescence…
2015 American Transplant Congress
Recreational Marijuana Use Is Not Associated With Worse Kidney Allograft Outcomes
G. Greenan, M. Anders, A. Leeser, J. Bromberg, S. Niederhaus.
Department of Surgery, University of Maryland, Baltimore, MD; Department of Anesthesiology, University of Maryland, Baltimore, MD; Department of Surgery, University of Maryland, Baltimore, MD; Department of Surgery, University of Maryland, Baltimore, MD; Department of Surgery, University of Maryland, Baltimore, MD.
Background: As marijuana (MJ) legalization is ongoing, kidney transplant programs need to develop listing criteria for MJ users. No data exist on whether recreational MJ…
2015 American Transplant Congress
Outcomes of Hispanic Kidney Transplant Recipients Under a Cyclosporine Versus Tacrolimus Based Immunosuppression Regimen
P. West-Thielke,¹ M. Campara,² A. Ladik,¹ E. Terranova,² E. Benedetti,¹ J. Thielke.²
¹Surgery, University of Illinois, Chicago; ²Pharmacy Practice, University of Illinois, Chicago.
Purpose: In 2005, an internal retrospective study at our institution showed a higher incidence of post transplant diabetes mellitus (PTDM) in our Hispanic kidney transplant…
2015 American Transplant Congress
Rat Forelimb Allotransplantation: A Novel Microsurgical Model for Optimized Functional Assessment After Reconstructive Transplantation
B. Kern,¹ S. Tuffaha,¹ M. Khusheim,¹ S. Xiang,¹ G. Furtmueller,¹ K. Sarhane,¹ J. Park,² A. Hoke,² W. Lee,¹ G. Brandacher.¹
¹Plastic & Reconstructive Surgery, Johns Hopkins University, Baltimore, MD; ²Neurology and NeuroSurgery, Johns Hopkins University, Baltimore, MD.
Background:Functional outcomes following vascularized composite allotransplantation (VCA) have been promising, but there is still room for improvement. Studies to investigate strategies to overcome this obstacle…
2015 American Transplant Congress
Impact of Early Urinary Tract Infections on Renal Graft Function
J. Rago, L. Bowman, D. Brennan, J. Hagopain, T. Horwedel.
Barnes Jewish Hospital, St Louis, MO.
Purpose: Describe the incidence of early urinary tract infections (UTI) after renal transplantation at a large academic transplant center. Evaluate the impact of early UTIs…
2015 American Transplant Congress
The Impact of MYH9 Polymorphic Variant rs5756168 on Kidney Allograft Function
J. Pazik,¹ M. Oldak,² Z. Lewandowski,³ D. Ozieblo,⁴ K. Michalska,⁵ E. Sitarek,¹ A. Sadowska,¹ M. Nowaczyk,⁵ T. Grochowiecki,⁶ J. Malejczyk,⁴ M. Durlik.¹
¹Department of Nephrology and Transplantation Medicine, Medical University of Warsaw, Warsaw, Poland; ²Institute of Physiology and Pathology of Hearing, Warsaw, Poland; ³Department of Epidemiology, Medical University of Warsaw, Warsaw, Poland; ⁴Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland; ⁵Department of Clinical Immunology, Medical University of Warsaw, Warsaw, Poland; ⁶General, Vascular and Transplant Surgery, Medical University of Warsaw, Warsaw, Poland.
The MYH9 gene was identified as a susceptibility locus associated with diminished filtration rate in the course of chronic nephropathies: primary focal segmental glomerulosclerosis (FSGS),…
2015 American Transplant Congress
In House Oxygen Persufflation of Cold Stored Livers Versus Simple Cold Storage in Extended Criteria Liver Grafts: Results of a Randomized Controlled Clinical Trial
A. Gallinat,¹ A. Paul,¹ D. Hoyer,¹ C. Klein,¹ S. Swoboda,¹ C. Ose,² Z. Mathe,¹ J. Treckmann,¹ T. Minor.³
¹Dept. of General-, Viszeral- und Transplantation Surgery, University Hospital Essen, Essen, Germany; ²Institute of Computer Science in Medicine, Biostatistics and Epidemiology, University Hospital Essen, Essen, Germany; ³Surgical Research Div., Universiy Clinic Surgery, Bonn, Germany.
Two hours of end-ischemic oxygen persufflation of cold stored porcine livers regenerates cellular energy dependent pathways and improves survival after transplantation. The present trial evaluated…
2015 American Transplant Congress
Delayed Tacrolimus (TAC) to Rapamycin (RAPA) Conversion in Renal Transplant Recipients With DGF/SGF
A. Haririan,¹ D. Klassen,¹ M. Keshtkar,¹ C. Drachenberg,² T. Dowling,³ E. Ramos,¹ R. Ugarte,¹ C. Cangro,¹ M. Weir.¹
¹Medicine, University of Maryland, Baltimore, MD; ²Pathology, University of Maryland, Baltimore, MD; ³Pharmacy, University of Maryland, Baltimore, MD.
The role of conversion from TAC to RAPA early after kidney transplantation in patients with DGF/SGF in improving graft function and delaying chronic allograft dysfunction…
2015 American Transplant Congress
Pancreas-Derived Mesenchymal Stem Cells from Chronic Pancreatitis Patients Enhance Islet Graft Function
M. Lawrence,¹ F. Kunnathodi,¹ N. Borenstein-Auerbach,¹ G. Yoshimatsu,¹ M. Kanak,² R. Shahbazov,¹ M. Takita,¹ M. Levy,³ B. Naziruddin.³
¹Baylor Research Institute, Dallas, TX; ²Baylor University, Waco, TX; ³Baylor Annette C. and Harold C. Simmons Transplant Institute, Dallas, TX.
PURPOSE: Islet transplantation represents a promising procedure to reverse or prevent diabetes. However, significant mass of islet graft is lost within hours of transplantation due…
2015 American Transplant Congress
Isolated Microcirculation Inflammation Negatively Impacts Renal Graft Function at 5 Years
A. Chapelet,¹ M. Touzot,¹ M. Fournier,² A. Cesbron,³ K. Renaudin,⁴ A. Moreau,⁴ E. Morelon,⁵ D. Anglicheau,⁶ M. Giral.¹
¹Institut de Transplantation Urologie Néphrologie, CHU Nantes, Nantes, France; ²EA 4275 SPHERE—Biostatistics, Pharmacoepidemiology and Subjective Measures in Health Sciences, University of Nantes, Nantes, France; ³Etablissement Français du Sang (EFS), Nantes, France; ⁴Service d'Anatomie et Cytologie Pathologiques, CHU Nantes, Nantes, France; ⁵Service de Néphrologie, Transplantation et Immunologie Clinique, Hôpital Edouard Herriot, Lyon, France; ⁶Service de Transplantation Rénale et de Soins Intensifs, Hôpital Necker, Paris, France.
BACKGROUND: Microcirculation inflammation (MI, ie: glomerulitis (g) and peritubular capillaritis (ptc)) associated with anti-HLA Donor Specific Antibody (DSA) with or without C4d deposits in ptc…