Articles tagged "Graft function"

2015 American Transplant Congress
Microcirculation Inflammation in Early Surveillance Renal Biopsy in Sensitized Patients Did Not Correlate With Graft Outcome
P. Souza,¹ D. Machado,¹ D. David,¹ G. Bezerra,¹ F. Jota de Paula,¹ H. Rodriges,² W. Nahas,¹ E. David Neto,¹ M. Castro.¹
¹Renal Transplant Unit, HC - FMUSP, S Paulo, SP, Brazil; ²Lab de HLA, InCor, S Paulo, SP, Brazil.
Introduction: Microcirculation inflammation (MI) at 3-month renal biopsies and preformed donor-specific antibodies (DSA) are considered predictors of bad outcome in sensitized patients. Earlier biopsies and…
2015 American Transplant Congress
Interstitial Fibrosis Is the Critical Determinant of Impaired Renal Function in Transplant Glomerulopathy
D. Toki,¹ H. Ishida,¹ M. Okumi,¹ T. Shimizu,¹ H. Shirakawa,¹ M. Inui,¹ K. Omoto,¹ K. Unagami,¹ T. Kanzawa,¹ K. Honda,² J. Koike,³ K. Tanabe.¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Pathology, Tokyo Women's Medical University, Tokyo, Japan; ³Pathology, Tama Hospital, Kanagawa, Japan.
PURPOSE: Transplant glomerulopathy (TGP) represents chronic antibody-mediated injury in the glomerular capillaries after renal transplantation, and is the main cause of graft failure. TGP is…
2015 American Transplant Congress
The Impact of the Arterial Reconstructions On the Living Donor Kidney Graft
T. Hiramitsu, K. Futamura, M. Okada, K. Ito, M. Tsujita, N. Goto, S. Narumi, Y. Watarai.
Transplant and Endocrine Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Aichi, Japan.
BackgroundProcurement side of living donor kidney is decided according to the kidney function. We procure the kidney with lower function for the remaining donor kidney…
2015 American Transplant Congress
Impact of Pretransplant Pregnancy On Immunization and Immunologic Outcome in Kidney Transplantation
O. Staeck,¹ D. Khadzhynov,¹ S. Kreimer,¹ E. Rajakangas,¹ C. Schönemann,² N. Lachmann,² K. Budde,¹ F. Halleck.¹
¹Nephrology, Charité Universitätsmedizin, Berlin, Germany; ²Zentrum für Transfusionsmedizin, Charité Universitätsmedizin, Berlin, Germany.
BACKGROUND:The detailed impact of pretransplant pregnancy on HLA alloimmunization and outcome after kidney transplantation is so far not well known.PATIENTS AND METHODS:A retrospective single center…
2015 American Transplant Congress
Differences in Genetic Variants That Influence Long-Term Graft Function Between Pancreas Transplant Donors and Recipients
M. Simmonds,¹ C. Duff,¹ A. Hamilton,¹ S. Mittal,^2,3,4 M. Barnardo,^2,3 S. Fuggle,^2,3 P. Friend,^2,3 S. Gough.^1,4
¹Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Oxford, United Kingdom; ²Oxford Transplant Centre, Oxford University Hospitals NHS Trust, Oxford, United Kingdom; ³Nufﬁeld Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom; ⁴Oxford National Institute for Health Research Biomedical Research Centre, Oxford, United Kingdom.
Genetic variation in caveolin-1, involved in signal transduction and tissue fibrosis, within pancreas transplant donors has been previously shown to correlate with decreased long-term graft…
2015 American Transplant Congress
Intimal Arteritis Associated With Subsequent Graft Dysfunction in ABO-Incompatible Kidney Transplantation
D. Toki,¹ H. Iahida,¹ M. Okumi,¹ T. Shimizu,¹ M. Inui,¹ K. Omoto,¹ H. Shirakawa,¹ K. Unagami,¹ K. Honda,² J. Koike,³ K. Tanabe.¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Pathology, Tokyo Women's Medical University, Tokyo, Japan; ³Pathology, Tama Hospital, Kanagawa, Japan.
Purpose: The diagnosis of acute antibody-mediated rejection (ABMR) is according to following all three evidences: 1) histologic evidence , 2) evidence of interaction with vascular…
2015 American Transplant Congress
The Impact of Delayed Graft Function (DGF) and Acute Rejection (AR) on the Decline in Allograft Function After Kidney Transplantation
J. Gill, J. Dong, C. Rose, J. Gill.
Nephrology, University of BC, Vancouver, BC, Canada.
Delayed Graft Function (DGF) and Acute Rejection (AR) are associated with an increased risk of graft loss. It is unclear whether this is a result…
2015 American Transplant Congress
Matching of Recipient and Donor Age Is the Most Powerful Risk Factor Affecting to Long-Term Graft Survival and Function
J. Lee,^1,2 Y. Lee,² J. Lee,^1,2 D. Joo,^1,2 K. Huh,^1,2 S. Kim,^1,2 Y. Kim,^1,2 M. Kim.^1,2
¹Department of Tranplantation Surgery, Yonsei University Health System, Seoul, Republic of Korea; ²The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Republic of Korea.
Recipient age and donor age were typical non-immunologic parameters affecting to graft survival rate (GSR). Using more than 3,000 cases of living donor transplantation database…
2015 American Transplant Congress
Furthering the Link Between Ischemia and Immunity: Development of New Antibody Following Prolonged Delayed Graft Function
A. Gilbert,¹ E. Hall,¹ O. Timofeeva,² M. Awwad,² M. Grafals,¹ P. Weems,¹ D. Li,² S. Rosen-Bronson,² J. Moore,¹ B. Javaid,¹ M. Cooper.¹
¹Department of Surgery, MedStar Georgetown Transplant Institute, Washington, DC; ²Department of Pathology, MedStar Georgetown Transplant Institute, Washington, DC.
Introduction The purpose of this study is to examine the relationship between prolonged ischemia (delayed graft function - DGF) and the development of de novo…
2015 American Transplant Congress
Relationship Between Delayed Graft Function (DGF) Severity and Predicted DGF Risk
E. Squiers,¹ B. Irish,¹ D. Odenheimer,¹ S. Erlich,¹ J. Grinyo, S. Feng, On Behalf of Quark DGF Study Investigators.
¹Quark, Fremont; ²UCSF, SF; ³U of Barcelona, BCN, Spain.
Historically, dialysis required in the first post-transplant (TX) week has defined DGF. This incidence-based definition fails to discriminate between short versus long courses of dialysis…