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Articles tagged "Graft function"

  • 2016 American Transplant Congress

    Long-Term Liver Function of Deceased Liver Transplantation Using Hepatitis B Surface Antigen Positive Grafts.

    W.-C. Lee,1 Y.-C. Wang,1 C.-H. Cheng,1 T.-H. Wu,1 C.-F. Lee,1 R.-S. Soong,1 T.-J. Wu,1 H.-S. Chou,1 K.-M. Chan,1 C.-S. Lee.2

    1Liver and Transplantation Surgery, Chang-Gung Memorial Hospital, Taoyuan, Taiwan; 2Hepatology, Chang-Gung Memorial Hospital, Taoyuan, Taiwan.

    Background: Deceased donors with hepatitis B [HBs Ag(+)] were not recommended to recover the livers for liver transplantation. However, in endemic area of hepatitis B…
  • 2016 American Transplant Congress

    Markers of Activation of Microvascular Endothelial Cells Predict a Poor Long-Term Graft Outcome in Early Renal Graft Biopsies Displaying Acute Tubular Necrosis.

    Y.-C. Dubois-Xu,1 P. Ahmadpoor,1 A. Corchia,1 D. Buob,2 P. Galichon,1 I. Brochériou,1 C. Suberbielle,3 A. Hertig,1 E. Rondeau.1

    1INSERM UMR_S1155, INSERM, Paris, France; 2Pathology, APHP, Hoptal Tenon, Paris, France; 3HLA Institute, INSERM_S940, Paris, France.

    Acute tubular necrosis (ATN), is a histopathological feature frequently seen in the early post renal transplant biopsies taken from patients with delayed graft function (DGF).…
  • 2016 American Transplant Congress

    Understanding the Drivers Behind an Early Post-KAS Rise in Delayed Graft Function (DGF) Rates.

    D. Stewart, A. Kucheryavaya, D. Klassen.

    UNOS, Richmond, VA.

    Background: DGF among solitary deceased donor kidney transplants (tx) increased by 22% (p<0.0001) -- from 24.6% to 30.1% -- during the first 6 months of…
  • 2016 American Transplant Congress

    Implications of Subclinical Borderline Acute Cellular Rejection Detected in Protocol Biopsies on Graft Outcomes.

    Z. Zaky,1 C. Yu,1 N. Elfadawy,2 A. Chiesa-Vottero,1 L. Herlitz,1 S. Flechner,1 E. Poggio.1

    1Glickman Urological and Kidney institute, Cleveland Clinic, Cleveland, OH; 2Internal Medicine, Univ. Hospitals Case Medical Center, Cleveland, OH.

    Background: The effects of subclinical borderline acute cellular rejection (BACR-defined as I1T1 per Banff criteria) detected in protocol biopsies (Bx) on subsequent graft function and…
  • 2016 American Transplant Congress

    A 30% Decrease in Post-kidney Transplant Estimated Glomerular Filtration Rate (eGFR) from 6 Mo-2 Y Is a Surrogate for 5 Y eGFR: Results from Clinical Trials in Organ Transplantation-(CTOT)-17.

    G. Faddoul,1 G. Nadkarni,1 D. Hricik,2 P. Heeger,1 CTOT17 Investigators.

    1Medicine and Recanati Miller Transplant Institute, Icahn School of Medicine, NY, NY; 2Medicine, Case Medical Center, Cleveland, OH.

    Predicting long-term kidney allograft outcomes using early clinical/biomarker data could guide individualized therapy. Emerging evidence in progressive native kidney disease indicates >30% decrease in eGFR…
  • 2016 American Transplant Congress

    The Significance of Microvascular Inflammation in Antibody-Mediated Rejection in ABO-Incompatible Kidney Transplantation.

    H. Ishihara,1 H. Ishida,1 K. Unagami,2 T. Hirai,1 M. Okumi,1 K. Omoto,1 T. Shimizu,1 K. Tanabe.1

    1Urology, Tokyo Women's Medical University, Tokyo, Japan; 2Nephrology, Tokyo Women's Medical University, Tokyo, Japan.

    Background: In ABO-incompatible (ABOi) transplantation, the criteria for antibody-mediated rejection (AMR) are controversial, as C4d deposition is common in ABOi. This study examined the impact…
  • 2016 American Transplant Congress

    Risk Stratification for Optimized Utilization of Deceased Donor Kidneys with Acute Kidney Injury by KDIGO Criteria.

    B. Yu,1 T. Koo,2 J. Lee,3 J. Yang,2 J. Ha,4 C. Ahn,1 Y. Kim,1 H. Lee.1

    1Internal Medicine, Seoul National University Hospital, Seoul, Korea; 2Transplantation Center, Seoul National University Hospital, Seoul, Korea; 3Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea; 4General Surgery, Seoul National University Hospital, Seoul, Korea.

    BackgroundDeceased donor kidneys with acute kidney injury (AKI) raise fear of poor graft outcomes to the transplant clinicians and consequently are often discarded. However, the…
  • 2016 American Transplant Congress

    The First Impressions: A Study in Pre and Post-Implantation Renal Grafts for Early Detection Markers of Delayed Graft Function and Recovery.

    S. Bontha,1 L. Suh,1 P. Dormish,1 R. Gehrau,1 E. Rhone,1 L. Gallon,3 A. King,2 C. Dumur,2 D. Maluf,1 V. Mas.1

    1UVA, Charlottesville; 2VCU, Charlottesville; 3Northwestern University, Chicago.

    Background: Delayed graft function (DGF) is mainly a consequence of ischemia and reperfusion injury (IRI) resulting in acute tubular necrosis. The degree of IRI is…
  • 2016 American Transplant Congress

    Pre-Transplant Panel of Reactive T Cells (PRT) as an Independent Predictor of 2-Year Kidney Graft Function.

    I. Gandolfini,1 E. Crespo,2 M. Baweja,1 U. Maggiore,3 P. Cravedi,1 P. Heeger,1 O. Bestard.2

    1Icahn School of Medicine, New York, NY; 2Bellvitge University Hospital, Barcelona, Spain; 3University of Parma, Parma, Italy.

    Background: The ELISPOT PRT quantifies frequencies of IFN-g-producing effector/memory T cells reactive against a panel of allogenic stimulators. In contrast to the donor-reactive ELISPOT, it…
  • 2016 American Transplant Congress

    Impaired Outcome of Kidney Transplants from Donors with Acute Kidney Injury.

    K. Schuette-Nuetgen,1 G. Thölking,1 H. Pavenstädt,1 S. Ehlert,1 B. Suwelack,1 D. Palmes,2 R. Bahde,2 S. Reuter.1

    1Department of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Muenster, Muenster, Germany; 2Department of General and Visceral Surgery, University Hospital of Muenster, Muenster, Germany.

    Given the gap between patients in need of a kidney transplantation and organs available, transplantation centers increasingly accept lower quality organs, e.g. from donors with…
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