ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Elucidating Clinical Factors Implicated in Primary Graft Dysfunction After Heart Transplantation.

R. Quintana-Quezada, I. Rajapreyar, Y. Yeh, S. Choi, I. Gregoric, P. Loyalka, B. Kar.

Advanced Heart Failure, University of Texas Medical School at Houston, Houston, TX.

Meeting: 2016 American Transplant Congress

Abstract number: B150

Keywords: Donors, Graft function, Heart failure, Heart transplant patients, unrelated

Session Information

Date: Sunday, June 12, 2016

Session Name: Poster Session B: Hearts and VADs in Depth - The Force Awakens

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Halls C&D

Related Abstracts
  • Prevalence, Risk Factors, and Clinical Management of Chronic Renal Dysfunction in Heart Transplant Recipients
  • Primary Graft Dysfunction vs. Primary Graft Failure: Are All Graft Problems Created Equal?

Primary graft dysfunction (PGD) is a frequent complication after heart transplantation (HT) and remains among the leading causes of mortality in these patients. We aim to identify factors implicated in the development of PGD, thus shedding light on possible preventive strategies.

Methods:Retrospective review of 99 patients who underwent HT between 2012 and 2015. 18 patients developed PGD. Donor and surgical procedure characteristics were studied in PGD patients and compared with patients without PGD.

Donor

 

No PGD

PGD

                P-value

DM

3%

2%

0.219

HTN

10.1%

3%

0.699

CPR

25.3%

8.1%

0.277

Downtime <10 min

67.7%

11.1%

0.55

Downtime >10 min

14.1%

7.1%

TBDACC <3 days

28.3%

14.1%

0.0011

TBDACC >3 days

54.5%

3%

Cocaine

4%

2%

1

Amphetamines

8.1%

4%

0.221

Opioids

8.1%

5.1%

0.049

Mean Inotropic Score

16.8

11.7

0.254

Troponin I <1

60.1%

10.1%

0.384

Troponin I >1

22.2%

7.1%

LVEF >50

69.7%

17.2%

0.294

Anoxia

13.1%

8.1%

0.021

Traumatic Brain Injury

23.2%

2%

0.227

Intracerebral hemorrhage

16.1%

6.1%

0.217

Surgical Procedure

CMV Status R-/D-

16.7%

4%

0.751

R-/D+

18.2 %

1%

0.477

R+/D-

12.1%

4%

0.183

R+/D+

35.4%

9.1%

0.613

Ischemic time <2 hr

13.1%

2%

0.9

2-4 hr

59.6%

13.1%

>4 hr

9.1%

3%

Blood type AB/A 

0

2

0.031

PRBCs transfusions >10

12.1%

3%

0.731

Results:In univariate analysis, opioid use (p=0.049), death due to anoxia (p=0.021) and receptor/donor blood type match AB/A were associated with PGD (p=0.031). Time from brain death to aortic cross clamp (TBDACC) ≥3 days was found protective from PGD development (p=0.0011). Multivariate analysis confirmed patients with a TBDACC ≥3 days had lower odds of developing PGD [OR=0.098 (95%CI=0.021-0.443), p=0.0026].

We found that a TBDACC ≥3 days was a significant protective factor for PGD. Prior studies suggest brain death triggers a catecholamine surge that increases the myocardiocytes susceptibility to injury. We hypothesize that if longer time elapses after brain death, adaptive tissue mechanisms take place to blunt this pathologic response, thus decreasing the likelihood of PGD.

CITATION INFORMATION: Quintana-Quezada R, Rajapreyar I, Yeh Y, Choi S, Gregoric I, Loyalka P, Kar B. Elucidating Clinical Factors Implicated in Primary Graft Dysfunction After Heart Transplantation. Am J Transplant. 2016;16 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Quintana-Quezada R, Rajapreyar I, Yeh Y, Choi S, Gregoric I, Loyalka P, Kar B. Elucidating Clinical Factors Implicated in Primary Graft Dysfunction After Heart Transplantation. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/elucidating-clinical-factors-implicated-in-primary-graft-dysfunction-after-heart-transplantation/. Accessed March 4, 2021.

« Back to 2016 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Penis Transplantation: First U.S. Experience.
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • A Decade of Donor-Derived Disease: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC).
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.