Articles tagged "Graft function"

2016 American Transplant Congress
Immediate Introduction of Everolimus Does Not Affect Wound Healing and Delayed Graft Function in Kidney Transplant Recipients: 3-Months Results from NEVERWOUND Study.
M. Carmellini,¹ P. Todeschini,² A. Secchi,³ S. Sandrini,⁴ E. Minetti,⁵ L. Furian,⁶ G. Spagnoletti,⁷ F. Pisani,⁸ G. Piredda,⁹ G. Cappelli,¹⁰ G. Tisone.¹¹
¹AOU Senese, Siena, Italy; ²AOP S.Orsola-Malpighi, Bologna, Italy; ³Osp San Raffaele IRCCS, Milano, Italy; ⁴AO Spedali Civili, Brescia, Italy; ⁵AOU Careggi, Firenze, Italy; ⁶AOU di Padova, Padova, Italy; ⁷PU A.Gemelli, Roma, Italy; ⁸POU S.Salvatore, L'Aquila, Italy; ⁹AO G.Brotzu, Cagliari, Italy; ¹⁰AOUP di Modena, Modena, Italy; ¹¹Fondazione PU Tor Vergata, Roma, Italy.
The NEVERWOUND study was designed to evaluate the impact of immediate vs. delayed introduction of everolimus (EVR) on wound healing complications (WHC) and delayed graft…
2016 American Transplant Congress
Circulating Angiotensin II Receptor: Possible Marker for Antibody Mediated Tissue Injury?
P. Kimball, F. McDougan, G. Gupta.
Transplant Surgery, VCU Health, Richmond, VA.
Background. Antibody mediated rejection is the leading cause of renal allograft failure. Membrane-bound angiotensin II receptor(AngII) in the renal allograft can be a target of…
2016 American Transplant Congress
Early De Novo DSA with T Cell Mediated Rejection (TCMR) Is Associated with Allograft Dysfunction with Chronic Injury.
A. Cherukuri, R. Mehta, P. Sood, A. Zeevi, S. Hariharan, D. Rothstein.
UPMC, Pittsburgh.
De novo anti-donor HLA specific antibody (DSA) detected post-renal transplantation is associated with adverse outcomes. However, the relationship between early de novo DSA and subsequent…
2016 American Transplant Congress
Elucidating Clinical Factors Implicated in Primary Graft Dysfunction After Heart Transplantation.
R. Quintana-Quezada, I. Rajapreyar, Y. Yeh, S. Choi, I. Gregoric, P. Loyalka, B. Kar.
Advanced Heart Failure, University of Texas Medical School at Houston, Houston, TX.
Primary graft dysfunction (PGD) is a frequent complication after heart transplantation (HT) and remains among the leading causes of mortality in these patients. We aim…
2016 American Transplant Congress
Replacing Cold Storage with Normothermic Ex Vivo Kidney Perfusion Improves Function of Grafts Retrieved After Circulatory Death (DCD).
J. Kaths,^1,2 Y.-M. Chun,¹ D. Cen,¹ J. Echeverri,¹ I. Linares,¹ P. Yip,³ R. John,³ D. Bagli,⁴ I. Mucsi,⁵ A. Ghanekar,¹ D. Grant,¹ L. Robinson,² M. Selzner.¹
¹Department of Surgery, Multi Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, ON, Canada; ²Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada; ³Laboratory Medicine & Pathobiology, Toronto General Hospital, Toronto, ON, Canada; ⁴Departments of Surgery (Urology) & Physiology, The Hospital for Sick Children, Toronto, ON, Canada; ⁵Department of Medicine, Multi Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, ON, Canada.
Normothermic ex vivo kidney perfusion (NEVKP) and avoidance of static cold storage (SCS) is an attractive strategy to minimize injury of DCD kidney grafts. We…
2016 American Transplant Congress
Unexpected Early Calcineurin Inhibitor Nephrotoxicity in Pediatric Kidney Transplant Recipients.
M. Yanik,¹ R. Mannon,² M. Seifert.¹
¹Pediatrics, University of Alabama at Birmingham, Birmingham, AL; ²Medicine, University of Alabama at Birmingham, Birmingham, AL.
Background: Calcineurin inhibitors effectively suppress the recipient immune response and facilitate early success in kidney transplantation. However, these drugs are potent nephrotoxins and contribute to…
2016 American Transplant Congress
Enhanced Activation of Hemostasis During Kidney Transplantation in Patients on Dialysis Compared to Pre-Emptively Transplanted Patients.
T. van den berg, G. Nieuwenhuijs-Moeke, S. Bakker, R. Pol, T. Lisman.
Groningen Transplant Center, University Medical Center Groningen, Groningen, Netherlands.
Introduction: It is generally assumed that dialysis patients (DP) have a more severe bleeding diathesis related to platelet dysfunction than pre-emptively transplanted patients (PEP) who…
2016 American Transplant Congress
Predictors of eGFR Slope at One Year in Kidney Transplants – A Big Data Approach.
J. Zhang, Z. Su, D. Taber, J. Marsden, W. Moran, P. Mauldin, T. Srinivas.
MUSC, Charleston.
Background: Estimated glomerular filtration rate (eGFR), a predictor of graft loss (GL) in kidney transplantation could inform intervention. National data yield eGFRs at fixed time…
2016 American Transplant Congress
Is Delayed Graft Function in Simultaneous Kidney-Pancreas Transplant Recipients Associated with an Increased Risk of Pancreas Graft Failure?
S. Singh,^1,2 S. Kim.^1,2,3,4
¹Division of Nephrology, Department of Medicine, University of Toronto, Toronto, Canada; ²Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada; ³Division of Nephrology and the Multi-Organ Transplant Program, University Health Network, Toronto General Hospital, Toronto, Canada; ⁴Division of Nephrology and the Kidney Transplant Program, St. Michael's Hospital, Toronto, Canada.
Background: Delayed graft function (DGF) in kidney transplant recipients is associated with adverse short and long-term outcomes. However, the impact of DGF of the kidney…
2016 American Transplant Congress
Acute Rejections and Incidence of De Novo DSA Depend on Donor Factors and Deceased Donor Kidney Associated Risk Assessed by the Kidney Donor Profile Index (KDPI).
O. Staeck, D. Khadzhynov, L. Lehner, A. Kleinsteuber, M. Duerr, E. Schrezenmeier, K. Budde, F. Halleck.
Nephrology, Charite, Berlin, Germany.
Introduction: Little data exist analyzing the influence of donor kidney quality on the immunologic outcome and applying the KDPI in a European cohort.Methods: This retrospective…