Articles tagged "Graft function"

2018 American Transplant Congress
Preoperative Antibiotics Treatment Decreases Endoplasmic Reticulum Stress and Protects Liver Transplant from Ischemia-Reperfusion Injury
T. Ito, F. Kaldas, K. Nakamura, S. Kageyama, A. Aziz, R. Busuttil, J. Kupiec-Weglinski.
Department of Surgery, The Dumont-UCLA Transplant Center, Los Angeles, CA.
Ischemia-reperfusion injury (IRI) represents a major risk factor of graft dysfunction in liver transplantation (LT). We have reported a critical role of endoplasmic reticulum (ER)…
2018 American Transplant Congress
Urinary Tract Infections after Renal Transplantation: Is Male Gender a Risk Factor for Resistant Microorganisms?
G. Guneri, A. Velioglu, E. Asicioglu, H. Arikan, S. Tuglular, C. Ozener.
Nephrology, Marmara University, School of Medicine, Istanbul, Turkey.
Introduction: Renal transplantation is the most effective treatment method for patients with the end-stage renal disease. The most common infections among these patients are urinary…
2018 American Transplant Congress
Predictive Scores for Delayed Graft Function Based on Hypothermic Machine Perfusion Variables in Kidney Transplantation
C. Ding,^1,2 W. Xue,^1,2 P. Tian,^1,2 X. Ding,^1,2 X. Pan,^1,2 H. Xiang,^1,2 Y. Li,^1,2 X. Tian,^1,2 F. Han,^1,2 Q. Tai.^1,2
¹Department of Kidney Transplantation, Nephropathy Hospital, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China; ²Institute of Organ Transplantation, Xi'an Jiaotong University, Xi'an, China.
Background Hypothermic machine perfusion (HMP) is increasingly being used in cardiac death kidney transplantation, but the value of assessing organ quality and predicting DGF through…
2018 American Transplant Congress
BETA-2 Score is an Excellent Tool for Monitoring of Islet Allograft Function and Early Detection of Transplant Dysfunction
P. Bachul,¹ J. Gołębiewska,² L. Basto,¹ M. Kijek,¹ N. Fillman,¹ K. Cieply,¹ K. Golab,¹ L-.J. Wang,¹ M. Tibudan,¹ C. Thomas,¹ A. Dębska-Ślizień,² J. Fung,¹ P. Witkowski.¹
¹Surgery, University of Chicago, Chicago; ²Nephrology, Medical University of Gdańsk, Gdańsk, Poland.
After validation of BETA-2 scores in our cohort of patients in relation to standard stimulation tests, we decided to assess the practical utility of BETA-2…
2018 American Transplant Congress
Sirolimus-Based, Prednisone-Free Regimen in Kidney Transplantation: Long Term Results of an Open-Label, Randomized Controlled Trial
A. Shetty,¹ B. Ho,¹ V. Mas,² Y. Kassis,¹ S. Park,¹ J. Leventhal,¹ D. Chhabra,³ L. Gallon.¹
¹Northwestern University, Chicago; ²University of Virginia, Charlottesville; ³Advocate Christ Medical Center, Chicago.
Background: Calcineurin (CNI) nephrotoxicity is implicated in chronic allograft dysfunction and presents an argument for CNI minimizing immunosuppression. We assessed the long-term effects of CNI…
2018 American Transplant Congress
Pumping Donor Kidneys Reduces DGF and Improves Allograft Survival without Affecting Rejection Rates
M. Samoylova, A. Nash, T. Brennan.
Surgery, Duke University, Durham, NC.
Recent evidence suggests that hypothermic machine perfusion of donor kidneys reduces delayed graft function (DGF), but data is sparse on its effect on allograft rejection.…
2018 American Transplant Congress
ACEI/ARB Use within One Year of Kidney Transplant is Associated with Less AKI and Graft Loss in Older Recipients
M. Posadas Salas, R. Rodriguez, P. Amaechi, V. Rao, D. Taber.
Medical University of South Carolina, Charleston, SC.
As short-term outcomes have improved, optimizing long-term graft survival remains a major focus of transplant programs. Older kidney transplant recipients are particularly vulnerable to acute…
2018 American Transplant Congress
Early Results from USHER: A Pilot Trial of Transplanting HCV-Infected Hearts into HCV-Negative Recipients Followed by Anti-Viral Therapy
R. McLean, P. P. Reese, M. Acker, P. Abt, A. Sicilia, N. Hornsby, P. Atluri, K. R. Reddy, E. Blumberg, V. Van Deerlin, D. S. Goldberg.
UPENN, Philadelphia.
Background: In 2016, over 600 hearts from deceased donors with active or prior hepatitis C virus (HCV) infection were discarded; most were otherwise good quality,…
2018 American Transplant Congress
Obese Patients Show Resistance to Narcotics Reduction after TPIAT for Chronic Pancreatitis
G. Yoshimatsu,¹ B. Naziruddin,³ K. Kumano,² H. Fernandez,³ E. Beecherl,³ N. Onaca.³
¹Fukuoka University, Fukuoka, Japan; ²Baylor Scott and White Research Institute, Dallas; ³Baylor Simmons Transplant Institute, Dallas.
Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment option for chronic pancreatitis patients with refractory pain. Patients with high BMI (>30) are known…
2018 American Transplant Congress
Long-Term Effects of Ketoconazole in Rapid Tacrolimus Metabolizers Post-Renal Transplantation
J. Ching,¹ S. Anders,¹ M. Janusek,¹ L. Hutchinson,¹ A. Freeman,¹ U. Patel,¹ A. Mohammed,⁴ H. Bohorquez.^2,3
¹Department of Pharmacy, Ochsner Clinical Foundation, New Orleans, LA; ²Multi-Organ Transplant Institute, Ochsner Clinical Foundation, New Orleans, LA; ³The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA; ⁴Academic Center, Ochsner Clinical Foundation, New Orleans, LA.
Introduction: Genetic polymorphisms in cytochrome P-450 enzymes can cause variations in tacrolimus (tac) metabolism. Ketoconazole (keto), a potent CYP450 and P-glycoprotein inhibitor, can be used…