2018 American Transplant Congress
Metabolic Complications 10-Years after Kidney Transplant
Background: Improving long-term outcomes is an important but unmet need after kidney transplant. Protocol renal allograft biopsies taken 10-years after transplant frequently show diabetic nephropathy…2018 American Transplant Congress
The Novel Polymer Pro-Drug APP-103 Reduces I/R Injury and Improves Graft Function in a Pre-Clinical Renal Transplant Model
Purpose: Ischemia-reperfusion injury (IRI) is the strongest non-HLA factor that augments allogenicity of transplanted organs. Damage subsequent to IRI is critically linked to an abundance…2018 American Transplant Congress
Adjunctive Corticosteroid Immunosuppression Improves Hyperbilirubinemia Following Liver Transplantation (OLT)
Drexel University, Philadelphia.
Background: Deceased donor orthotopic liver transplantation (OLT) can result in significant delayed function, manifesting as protracted hyperbilirubinemia, depending on the intensity of the ischemia/reperfusion injury…2018 American Transplant Congress
Mitochondrial Quality Control through PGC-1α in Syngenic Mouse Heart Transplant
1Anesthesiology, Duke University, Durham, NC; 2Surgery, Duke University, Durham, NC.
Intro: Impaired mitochondrial function plays a role in graft dysfunction after transplant, and recovery is facilitated by mitochondrial quality control (MQC). Two key elements of…2018 American Transplant Congress
Pancreas Graft Function >10 Years: The Cumulative US Experience
1SUNY Downstate Medical Center, Broooklyn, NY; 2SUNY Upstate Medical University, Syracuse, NY.
Background and Study Purpose: The cumulative US experience with long-term pancreas graft function has not been reported.Methods: Between 1966 and 2005, 18,197 pancreas transplants due…2018 American Transplant Congress
Impact of Postoperative Serum Chloride Changes on Graft Function and Acute Rejection in Recipients of Living Kidney Transplants
Background: In the non-transplant setting, hyperchloremia has been associated with kidney injury. We sought to study the impact of serum chloride (SCl) on transplant outcomes.Methods:…2018 American Transplant Congress
Increased Expression of HLA-DPB1 in Pre-Implantation Kidney Biopsies is Associated with Poor Late Graft Function
In a previous gene expression microarray study in pre-implantation biopsies (PIB) from kidneys of 53 deceased donors (GeneChip® Human Gene 1.0 ST Arrays, Affymetrix; GEO…2018 American Transplant Congress
Graft CEACAM1 is Essential to Autophagy Induction and T-Cell Regulation in Liver Transplantation: From Mouse-to-Human
We have documented crucial role of TIM-3 dependent T cell dysfunction in mouse orthotopic liver transplantation (OLT). CEACAM1 (CM1; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1),…2018 American Transplant Congress
Hypothermic Oxygenated Machine Perfusion in Liver and Kidney Transplantation of Extended Criteria Donors: A Phase-1 of Clinical Trial
In the field of liver (LT) and kidney transplantation (KT), extended criteria donors (ECD) offer an additional organ source that is more vulnerable for early…2018 American Transplant Congress
Unbiased Sequencing of Urine Cell-Free DNA (cfDNA) to Evaluation Urine Virome and Associated Renal Allograft Damage
Intro: Virus reactivation leading to graft damage is a frequent post-kidney transplant (KTx) complication. Immunosuppressed individuals are at risk for multiple virus infections simultaneously. Current…
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