Articles tagged "Graft function"

2018 American Transplant Congress
SIRT1-Ikaros Axis Promotes Macrophage M2 Polarization and Protects Liver Graft from Ischemia-Reperfusion Injury
K. Nakamura,¹ S. Kageyama,¹ X. Li,² A. Aziz,¹ R. Sosa,³ E. Reed,³ F. Kaldas,¹ R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, UCLA, Los Angeles, CA; ²NIEHS, Durham, NC; ³Pathology, UCLA, Los Angeles, CA.
Although pre-clinical studies have reported the efficacy of Sirtuin 1 (SIRT1) to protect livers from ischemia-reperfusion injury, its clinical relevance in liver transplantation (LT) has…
2018 American Transplant Congress
Urinary Chemokine CXCL-10 in Long Term Renal Transplant Patients Associates with Urinary Tract Infections and Microvascular Damage
G. Irish,^1,2 M. Hockley,^1,2 S. Kireta,^1,2 J. Johnson,^1,2 R. Carroll.^1,2
¹Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia; ²The Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.
Non-invasive biomarkers are needed to predict rejection post kidney transplantation. In the early transplant period, urinary CXCL-9 and CXCL-10 associate with rejection. We assessed the…
2018 American Transplant Congress
Inter-Correlations between Psycho-Social Pre-Transplant Determinants of Post-Transplant Kidney Allograft Function
S. Shah, A. Gamilla-Crudo, B. Schreiber, C. Machner, O. Aleter, M. Mujtaba.
Transplant Services, UTMB, Galveston, TX.
Psycho-social factors are common in patients with advanced and end stage kidney disease and they may be associated with post kidney transplant outcomes. The aim…
2018 American Transplant Congress
β-Glucuronidase Gene Expression in Stool Samples Associated with Chronic Allograft Dysfunction in Kidney Transplants
A. Israni,^1,2 D. Knights,³ G. Al-Ghalith,³ A. Muthusamy,² B. Wu,⁴ W. Oetting,⁵ D. Schaldt,² R. Remmel,⁵ P. Jacobson,⁵ For DeKAF Genomics & GEN03 Investigators.¹
¹Medicine, HCMC, University of MN (UMN), Minneapolis; ²Minneapolis Medical Research Foundation (MMRF), Mpls; ³Computer Science, UMN, Mpls; ⁴Biostatistics, UMN, Mpls; ⁵College of Pharmacy, UMN, Mpls.
Background: Myocophenolate mofetil (MMF) is a prodrug that is extensively and rapidly converted to the active component, mycophenolic acid (MPA). MPA undergoes extensive enterohepatic recycling…
2018 American Transplant Congress
Kidney Transplantation (KTx) Using Kidneys from Deceased Donors (DD) with AKIN Stage 2 and 3 Are Associated with Excellent Graft Outcomes
A. Kumar, K. Reddy, A. Srinivasan, J. Huskey, H. Khamash, M. Smith, A. Moss, R. Heilman.
Mayo Clinic, Phoenix.
BackgroundKTx from DD with AKI can be a good source of kidneys however these kidneys are underutilized. The aim of this study is to determine…
2018 American Transplant Congress
Direct-Acting Antiviral Therapy Immune-Mediated Graft Dysfunction in Liver Transplant Recipients with Hepatitis C
C. Chan,¹ E. Agudelo,² J. Haydek,³ M. Hoteit,⁴ M. Laurito,⁵ J. Norvell,³ T. Schiano,⁶ N. Terrault,² E. Verna,⁵ A. Yang,¹ J. Levitsky.¹
¹Northwestern University, Chicago, IL; ²UCSF, San Francisco, CA; ³Emory University, Atl, GA; ⁴University of Pennsylvania, Philadelphia, PA; ⁵Columbia University, NY, NY; ⁶Mount Sinai, NY, NY.
Background and Aims:Interferon (IFN) treatment of hepatitis C virus (HCV) infection after liver transplantation (LT) can result in severe immune-mediated graft dysfunction (IGD). The occurrence…
2018 American Transplant Congress
Do Protocol Biopsies in the Highly Sensitized Improve Renal Allograft Survival? A Single Center Evaluation of 2 Year Graft Function
S. Kuppachi, R. Kalil, M. Fraer, M. Sanders, M. Swee, Z. Stewart, C. Thomas.
Organ Transplant Center, University of Iowa, Iowa City, IA.
Highly sensitized kidney transplant recipients (hsKTR) are at an increased risk of antibody mediated rejection (AMR). Following implementation of the new kidney allocation system (KAS)…
2018 American Transplant Congress
Comparison of Continuous Normothermic Ex Vivo Kidney Perfusion to Hypothermic Preservation Methods in Pig Kidneys Donated after Cardiac Death
M. Hamar,^1,2 P. Urbanellis,¹ D. Kollmann,¹ I. Linares,¹ M. Kaths,¹ D. Bagli,³ A. Konvalinka,⁴ I. Mucsi,¹ A. Ghanekar,¹ L. Robinson,² M. Selzner.¹
¹Multi Organ Transplant Program, TGH, Toronto, ON, Canada; ²Division of Nephrology, The Hospital of Sick Children, Toronto, ON, Canada; ³Dept. of Surgery (Urology) & Physiology, The Hospital of Sick Children, Toronto, ON, Canada; ⁴Dept. of Medicine and Institute of Medical Science, UHN and Univ. of Toronto, Toronto, ON, Canada.
Background: Strategies to decrease preservation-related injury in renal grafts donated after circulatory death urgently needed. This highlights the importance of direct comparison of dynamic preservation…
2018 American Transplant Congress
Outcomes of Retroperitoneoscopic Live Donor Nephrectomy (RPLDN): Experience of 1100 Cases at a Single Center
K. Omoto,^1,2 M. Okumi,¹ Y. Kakuta,¹ H. Noguchi,¹ K. Unagami,¹ M. Inui,¹ H. Ishida,¹ K. Tanabe.¹
¹Department of Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Department of Transplant Surgery, Toda Chuo General Hospital, Toda, Japan.
INTRODUCTION: Laparoscopic donor nephrectomy is a standard method of donor nephrectomy. We have tried to establish the technique of pure retroperitoneoscopic live donor nephrectomy (RPLDN)…
2018 American Transplant Congress
Kidney Transplantation (KTx) Using Kidneys from Deceased Donors (DD) with Severe Acute Kidney Injury (AKI) Requiring Renal Replacement Therapy (RRT)
A. Srinivasan, R. Heilman, A. Kumar, H. Khamash, M. Smith, K. Reddy, A. Moss.
Mayo Clinic, Phoenix.
Background:Transplant centers are reluctant to accept kidneys from DD with severe AKI necessitating utilization of RRT. The aim of this study is to determine the…