Articles tagged "Graft function"

2019 American Transplant Congress
A Prospective Randomized Multicenter Trial (B E S T Trial) of Belatacept-Based C N I- and Corticosteroid-Free Immunosuppression: Final Two Year Results
D. B. Kaufman¹, A. R. Shields², J. P. Leone³, A. Wiseman⁴, A. J. Matas⁵, P. West-Thielke⁶, J. Lipscomb², E. King², R. R. Alloway⁷, E. S. Woodle for the BEST Study Group²
¹University of Wisconsin, Madison, WI, ²University of Cincinnati, Cincinnati, OH, ³Tampa General, Tampa, FL, ⁴University of Colorado School of Medicine, Denver, CO, ⁵University of Minnesota, Minneapolis, MN, ⁶University of Illinois, Chicago, Chicago, IL, ⁷University of Cincinnati, Cincinnati, WI
*Purpose: The BEST Trial (Belatacept-based Early Steroid Withdrawal Trial) is a prospective, randomized, multi-center trial designed to compare two belatacept (BELA)-based calcineurin inhibitor-free (CNI), early…
2019 American Transplant Congress
Dynamic Characterization of Cells in the Perfusate from Cold Ischemic Liver Grafts
R. J. de Vries, C. Pendexter, S. E. Cronin, B. Marques, J. F. Markmann, S. L. Stott, H. Yeh, M. Toner, K. Uygun, S. N. Tessier
Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA
*Purpose: Injury during preservation is a complex process that affects graft function. A deeper understanding and better prediction of liver viability are demanded to improve…
2019 American Transplant Congress
Normothermic Ex-Situ Liver Perfusion Parameters of Liver Viability in a Porcine Model of Liver Transplantation with Marginal Grafts
I. Linares-Cervantes¹, J. Echeverri¹, S. Cleland¹, M. Kaths¹, R. Rosales¹, T. Goto¹, D. Kollmann¹, M. Hamar¹, P. Urbanellis¹, L. Mazilescu¹, S. Ganesh¹, O. Adeyi¹, P. Yip¹, B. Bojko², P. Gorynzka², K. Gorynski², D. Grant¹, N. Selzner¹, M. Wasowicz¹, M. Selzner¹
¹Toronto General Hospital, Toronto, ON, Canada, ²University of Nicolaus Copernicus, Torun, Poland
*Purpose: Evaluate parameters of liver viability during normothermic ex-situ liver perfusion (NEsLP) prior to transplantation.*Methods: In this study, we investigated prior assessed parameters and new…
2019 American Transplant Congress
HbA1c as a Noninvasive Predictor of Chronic Histopathologic Changes in Living Donors for Kidney Transplantation
K. Tanaka¹, S. Nishida¹, K. Kinoshita¹, Y. Hidaka¹, M. Toyoda², A. Inadome³, A. Takeda⁴, H. Yokomizo⁵, S. Uekihara⁶, J. Shoji⁷, S. Yamanaga¹
¹Surgery, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan, ²general medicine, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan, ³Urology, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan, ⁴Nephrology, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Japan, ⁵Surgery, Japanese Red Cross Kumamoto Hospital, kumamoto, Japan, ⁶general medicine, Japanese Red Cross Kumamoto Hospital, kumamoto, Japan, ⁷Nephrology, UCSF Connie Frank Transplant Center, San francisco, CA
*Purpose: The degree of chronic histopathologic changes in renal allografts, including interstitial fibrosis, tubular atrophy, and arteriolar hyalinosis, can have clinical implications in long-term allograft…
2019 American Transplant Congress
Impact of Delayed Graft Function on Allograft Survival in DCD versus DBD Kidneys
T. Ishaque, A. B. Massie, J. Ruck, C. Holscher, J. G. Wang, D. L. Segev
Surgery, Johns Hopkins School of Medicine, Baltimore, MD
*Purpose: Several single-center studies have suggested no link between delayed graft function (DGF) and graft survival in recipients of donation after cardiac death (DCD) kidneys,…
2019 American Transplant Congress
How Much Does Graft Function Cost Us? A Financial Analysis of Delayed Graft Function in Kidney Transplant Recipients
A. Yaldo, I. Bajjoka, C. Crombez, M. Abouljoud
Henry Ford Transplant Institute, Detroit, MI
*Purpose: Kidney transplant recipients (KTR) who receive dialysis post-transplant experience worse outcomes during the first year post-transplant. Whether KTR discharged with elevated levels of serum…
2019 American Transplant Congress
Oxygenated Hypothermic Machine Perfusion of Kidneys Donated after Circulatory Death: An International Randomised Controlled Trial
I. Jochmans¹, H. S. Hofker², L. Davies³, S. Knight³, J. Pirenne¹, R. J. Ploeg³, -. on behalf of COPE and participating centres⁴
¹Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium, ²University Medical Center Groningen, Groningen, Netherlands, ³University of Oxford, Oxford, United Kingdom, ⁴Belgium, Netherlands, United Kingdom
*Purpose: An international, double-blinded, randomised, paired phase 3 trial designed to determine the effect on 1-year graft function of continuous oxygenated (HMPO) vs non-oxygenated hypothermic…
2019 American Transplant Congress
Outcomes after Simultaneous Kidney Pancreas versus Pancreas after Kidney Transplantation
S. Parajuli, A. Arunachalam, K. Swanson, F. Aziz, N. Garg, R. Redfield, D. Kaufman, A. Djamali, J. Odorico, D. Mandelbrot
University of Wisconsin, Madison, WI
*Purpose: Simultaneous pancreas and kidney (SPK) or pancreas after kidney (PAK) transplant are potential options for diabetic ESRD patients. Historically, PAK pancreas graft outcomes were…
2019 American Transplant Congress
Utility of AlloSure Monitoring in Simultaneous Kidney and Pancreas Recipients
J. A. Klein, A. Gupta, P. Budhiraja, D. Cibrik
Nephrology, University of Kansas Medical Center, Kansas City, KS
*Purpose: Determine utility and efficacy of donor-derived cell free DNA (dd-cfDNA) monitoring in simultaneous kidney and pancreas (SPK) recipients compared to kidney transplant alone (KTA).…
2019 American Transplant Congress
First UK Experience of the Molecular Microscope (MMDX™) in the Kidney Transplant Clinic
C. Lawrence¹, S. Thiru², A. Manoj¹, S. Fluck¹
¹Renal Medicine, The Lister Hospital, Stevenage, United Kingdom, ²Histopathology, Addenbrookes Hospital, Cambridge, United Kingdom
*Purpose: Molecular diagnostic methods are now included in the Banff classification of kidney transplant pathology. Traditional histopathology may be limited by intra/inter pathologist variation. The…