Articles tagged "Graft function"

2019 American Transplant Congress
Single Cell Sequencing of Human Kidney Allograft
H. Yang¹, H. Suryawanshi², M. Lagman¹, M. Lubetzky¹, A. Alonso¹, S. Seshan¹, T. Tuschl², M. Suthanthiran¹, T. Muthukumar¹
¹Weill Cornell Medicine, New York, NY, ²Rockefeller University, New York, NY
*Purpose: Transcriptome-based clustering of individual cells within the kidney allograft may help identify cell type-specific injury and has the potential to redefine the current histopathology-based…
2019 American Transplant Congress
Improving Medication Adherence and Outcomes in Adult Kidney Transplant Patients Using SystemCHANGE^TM: Results of the Medication Adherence Given Individual Change (MAGIC) Randomized Clinical Trial
M. R. Wakefield¹, C. M. Ashbaugh², L. Remy³, D. Aholt³, C. Miller³, S. Ye³, D. K. Hathaway⁴, D. Clark⁴, V. S. Staggs⁵, K. Goggin⁶, R. J. Ellis⁷, C. L. Russell³
¹Surgery/Urology, University of Missouri School of Medicine, Columbia, MO, ²Transplant, University of Missouri Health Care, Columbia, MO, ³School of Nursing and Health Studies, University of Missouri-Kansas City, Kansas City, MO, ⁴College of Nursing, University of Tennessee HSC, Memphis, TN, ⁵Health Services and Outcomes Research, Children's Mercy Kansas City, Kansas City, MO, ⁶Health Services and Outcomes Research, Children's Mercy Kansas City and Schools of Medicine and Pharmacy, University of Missouri-Kansas City, Kansas City, MO, ⁷School of Nursing, Indiana University, Indianapolis, IN
*Purpose: Medication non-adherence is an obdurate problem associated with poor outcomes and staggering costs. Even with multi-faceted interventions, effect sizes reported in meta-analyses of medication…
2019 American Transplant Congress
Impact of Tacrolimus Formulation on Tacrolimus Level Coefficient of Variations
S. January¹, T. Horwedel², J. Hagopian¹, C. Carthon¹, A. Gharabagi³, R. Delos Santos⁴
¹Barnes-Jewish Hospital, Saint Louis, MO, ²Veloxis Pharmaceuticals, Inc., Cary, NC, ³Saint Louis College of Pharmacy, Saint Louis, MO, ⁴Washington University School of Medicine, Saint Louis, MO
*Purpose: Increased coefficient of variation (CV) of tacrolimus (FK) levels, indicating high intra-patient FK level fluctuations, are associated with increased rejection, development of donor-specific antibodies,…
2019 American Transplant Congress
Intrinsic Organ Quality Assessment Using Integrative Short Outcome Prediction Composite Scores
K. Archer¹, V. Bontha², Y. Zhang¹, J. Eason³, A. Bajwa², L. Gallon⁴, E. Akalin⁵, D. Maluf², V. Mas⁶
¹OSU, Columbus, OH, ²UTHSC, Memphis, TN, ³UTHSC Director of Transplant Institute, Memphis, TN, ⁴NWU, Chicago, IL, ⁵Albert Einstein College of Medicine, NYC, NY, ⁶UTHSC Director of Transplant Research Institute, Memphis, TN
*Purpose: Organs discards continue to be high due to lack of accurate tools to assess donor quality and predict organ function.To identify characteristics associated with…
2019 American Transplant Congress
Meet Your Mate: Lessons Gleaned from Analysis of 154 Paired Kidneys Transplanted at a Single Center
M. Lubetzky¹, M. Aull², K. Rhee¹, S. Sultan², S. Kapur²
¹Division of Nephrology, New York, NY, ²Surgery, NYP-Weill Cornell, New York, NY
*Purpose: The factors affecting graft and patient survival are in many studies confounded by center and donor related factors. Mate kidney analyses can help to…
2019 American Transplant Congress
Effects of Proton Pump Inhibitors on Allograft Rejection and Adverse Effects in Kidney Transplant Recipients: A Systemic Review and Meta-Analysis
B. Boonpheng¹, C. Thongprayoon², M. A. Mao³, W. Cheungpasitporn⁴
¹Internal Medicine, East Tennessee State University, Johnson City, TN, TN, ²Nephrology, Mayo Clinic, Rochester, MN, MN, ³Nephrology, Mayo Clinic, Rochester, MN, ⁴Internal Medicine, University of Mississippi Medical Center, Jackson, MI, MS
*Purpose: The adverse renal effects of proton pump inhibitors (PPIs) are being increasingly recognized in both the general population and chronic kidney disease patients. Several…
2019 American Transplant Congress
Innate Immunity in Brain Dead Donors: Implications of Necroptosis in Kidney Allograft Outcomes
A. Ang¹, A. Zmijewska², T. M. Stevens³, J. Murphy¹, R. B. Mannon²
¹School of Medicine, UAB, Birmingham, AL, ²Medicine/Nephrology, UAB, Birmingham, AL, ³Pathology, UAB, Birmingham, AL
*Purpose: Regulated necrosis (necroptosis) has been implicated in renal injury from nephrotoxic agents and ischemia. With the use of suboptimal brain dead donors (BDDs) to…
2019 American Transplant Congress
One Study: A Consortium Model of Clinical Trials Optimized for Comparing New Immune Therapies via Centralized Immune Monitoring
B. Sawitzki¹, S. Schlickeiser¹, M. Streitz¹, K. Jürchott¹, J. Hutchinson², E. Geissler², P. Investigators³
¹Charite Universitätsmedizin, Berlin, Germany, ²University of Regensburg, Regensburg, Germany, ³ONE Study Consortium, EU, Germany
*Purpose: Immune regulatory cell subpopulations can potentially control immune responses to allow immunosuppression (IS) drug minimization. In the ONE Study, an EU FP7-funded research group…
2019 American Transplant Congress
Renal Outcomes from Expander-1: Pilot Study of HCV+ Donor Kidneys for HCV- Kidney Recipients
S. Thaduri¹, C. Durand¹, N. Desai², D. Segev², N. Bair¹, D. Brown¹, F. F. Naqvi¹
¹Medicine, -Johns Hopkins University, -Baltimore, MD, ²Surgery, -Johns Hopkins University, -Baltimore, MD
*Purpose: Direct acting antivirals (DAAs) have led to high cure rates (>95%) for hepatitis C. Utilization of HCV+ donor kidneys for patients with advanced kidney…
2019 American Transplant Congress
De Novo Belatacept to Delay Tacrolimus Initiation in Renal Transplants with Delayed Graft Function
A. Dao, A. Reyad, L. Kautzman, M. Madhrira, I. Memon, O. Elmhishi, B. Sankarapandian, J. Johnson, S. Patel, S. Allam
Medical City Fort Worth Transplant Institute, Fort Worth, TX
*Purpose: Delayed graft function (DGF) post renal transplant (RT) is associated with adverse patient and graft outcomes. Early tacrolimus (FK) initiation with high trough levels…