Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall C & D
*Purpose: We have previously reported that contrast enhanced ultrasonography (CEUS) is useful to evaluate the graft circulation and to predict the endocrine function of the pancreas graft (Pancreas 2018;47(5):617-624.). In that study, we demonstrated that the time between the time to peak intensity in the parenchyma and that in the vein (delta-Tp(P-V)) reflected the graft perfusion. Delta-Tp(P-V) within 24 hours after transplantation (delta-Tp(P-V)24h) showed a significant correlation with an insulin secretion at early period after transplantation (Tx). In the present study, we examined the relationship between the graft circulation and the graft function at 1 month and 1 year after Tx.
*Methods: We performed CEUS in 26 patients within 24 hours after pancreas transplantation and calculated delta-Tp(P-V)24h. Graft function was evaluated with a glucagon stimulation test at 1 month and 1 year after Tx. We examined the relationship between delta-Tp(P-V)24h and the graft function.
*Results: Median delta-Tp(P-V)24h was 4.47 (3.15-6.0) seconds. From the results of previous study, we divided the patients into the two groups, based on the levels of delta-Tp(P-V)24h: the standard group (≤6.10 s) and the delayed group (>6.10 s). The standard group included 20 patients, and the delayed group included 6 patients. The patients in the standard group showed a significantly higher C-peptide increment (delta-CPR) in the glucagon stimulation test both at 1 month after Tx (3.07(2.61-3.61) vs 1.15 (1.06-1.23), p<0.01) and at 1 year after Tx (3.52(2.72-4.38) vs 1.65 (0.91-2.25), p<0.05). In the standard group, delta-CPR at 1 year after Tx significantly increased as compared to those at 1 month after Tx. In contrast, no increase of delta-CPR was observed at 1 year after Tx as compared to those at 1 month after Tx in the delayed group.
*Conclusions: These results demonstrated that pancreatic graft perfusion within 24 h influenced long-term insulin secretion after pancreas transplantation. CEUS is useful for the prediction of the endocrine function after pancreas transplantation.
To cite this abstract in AMA style:Aida N, Kenmochi T, Ito T, Kurihara K, Kawai A, Nishikawa T, Hiratsuka I, Shibata M, Suzuki A, Hasegawa M, Kusaka M, Hoshinaga M. Contrast-Enhanced Ultrasonography Predicts Insulin Secretion Ability at 1 Year after Pancreas Transplantation [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/contrast-enhanced-ultrasonography-predicts-insulin-secretion-ability-at-1-year-after-pancreas-transplantation/. Accessed August 18, 2019.
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