ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Graft failure"

  • 2018 American Transplant Congress

    Facial Allotransplantation: An Early Look at OPTN Data

    J. Wainright,1 L. Levin,2 L. Cendales,3 C. Wholley,1 W. Cherikh,1 D. Klassen,1 B. Pomahac.4

    1United Network for Organ Sharing, Richmond, VA; 2University of Pennsylvania, Philadelphia, PA; 3Duke University School of Medicine, Durham, NC; 4Brigham and Women's Hospital, Boston, MA.

    Craniofacial Vascularized Composite Allograft (VCA) transplantation is a developing area in the field of transplantation. Thirteen craniofacial transplants have been performed in the US since…
  • 2018 American Transplant Congress

    Antiproteinuric Effect of Spironolactone in Renal Transplantation: Effectiveness and Clinical Outcomes

    M. Sousa, C. Do Valle, G. Rivelli, L. Camargo, R. Zollner, M. Mazzali.

    University of Campinas, Campinas, Sao Paulo, Brazil.

    Background: aldosterone is involved in development of fibrosis in kidney transplantation. Blockade of aldosterone receptor appears to be effective in treatment for chronic allograft dysfunction,…
  • 2018 American Transplant Congress

    Relationship between Living Kidney Donor Follow-Up GFR and Recipient Graft Loss

    C. Holscher,1 T. Ishaque,1 C. Haugen,1 S. DiBrito,1 K. Jackson,1 A. Muzaale,1 A. Massie,1,2 M. Henderson,1 J. Garonzik Wang,1 D. Segev.1,2,3

    1Johns Hopkins School of Medicine, Baltimore; 2Johns Hopkins School of Public Health, Baltimore; 3Scientific Registry of Transplant Recipients, Minneapolis.

    In living kidney transplantation, it is reasonable to believe a donated kidney's function would be associated with the function of the donor's remaining kidney. Indeed,…
  • 2018 American Transplant Congress

    The Likelihood of Re-Transplantation in Patients Undergoing Allograft Nephrectomy

    G. Lucisano,1 P. Brookes,2 E. Santos-Nunez,2 N. Firmin,2 N. Gunby,2 S. Hassan,1 A. Gueret-Wardle,1 M. Willicombe,1 D. Taube.1

    1Renal and Transplant Centre, Imperial College Healthcare NHS Trust, London, United Kingdom; 2Histocompatibility and Immunogenetics, Imperial College Healthcare NHS Trust, London, United Kingdom.

    Introduction: transplant nephrectomy (NX) is a known cause of allosensitisation after graft failure. As yet, there is no consensus for the management of the patient…
  • 2018 American Transplant Congress

    Acute Murine CMV Infection Results in Loss of Intragraft CD73HIFR4HIPD1+ CD4 T Cells and Graft Rejection in Previously Tolerant Recipients

    A. Dangi,1 L. Zhang,1 X. Zhang,2 X. Luo.1,2

    1Division of Nephrology and Hypertension, Department of Medicine, Northwestern University, Chicago, IL; 2Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL.

    Background: Transplantation tolerance in human recipients has been achieved in recent trials. Nevertheless, the impact of highly prevalent and clinically relevant cytomegalovirus (CMV) infection on…
  • 2018 American Transplant Congress

    Scoring Transplant Glomerulopathy Using Morphometry: Correlation with Banff Criteria

    M. Morales, A. Denic, W. Park, B. Smith, M. Alexander, M. Stegall.

    William J.von Liebig Transplant Center, Mayo Clinic, Rochester, MN.

    Background: Transplant glomerulopathy (TG) is a prognostic marker for graft survival. Still, scoring TG using the Banff cg-score remains a challenge and no assessments in…
  • 2018 American Transplant Congress

    The Association between Transplant Glomerulopathy and Graft Outcomes among Patients Undergoing Kidney Transplantation: Results of a Meta-Analysis

    G. Kovács,1 G. Devercelli,2 Z. Vokó,1,3 T. Zelei,1 I. Hirji,2 P. Keown.4,5

    1Syreon Research Institute, Budapest, Hungary; 2Shire, Lexington, MA; 3Health Policy & Health Economics, Eötvös Loránd University, Budapest, Hungary; 4Syreon Corporation, Vancouver, BC, Canada; 5University of British Columbia, Vancouver, BC, Canada.

    Transplant glomerulopathy (TG) can lead to irreversible kidney damage. TG is recognized as a surrogate marker for poor outcomes, including graft failure and loss among…
  • 2018 American Transplant Congress

    Linking Donor Ischemia Reperfusion Injury (IRI) to Costimulatory Blockade Resistant Murine Heart Graft Rejection through Complement-Initiated Necroptosis

    R. Ang, N. Chun, A. Ting, P. Heeger.

    Immunology Institute, Translational Transplant Research, Icahn School of Medicine at Mount Sinai, New York, NY.

    We previously showed that prolonged cold ischemic storage (CIS) of donor B6 hearts results in complement dependent, CTLA4Ig-resistant rejection in BALB/c recipients. In this system,…
  • 2018 American Transplant Congress

    Title: Donor-Derived Cell Free DNA Predicts Development of Clinically Significant Changes in Donor Specific Antibody Following Kidney Transplant

    A. Brubaker,1 D. Stoltz,1 M. Grskovic,2 R. Woodward,2 A. Gallo.1

    1Department of Surgery, Division of Abdominal Transplantation, Stanford University, Stanford, CA; 2CareDx, Brisbane, CA.

    Background: Recently, high immunologic risk patients comprise a significant percentage of the total adult renal transplants performed yearly. Surveillance management of these patients and interpretation…
  • 2018 American Transplant Congress

    Standard Induction Immunosuppression Interferes with the Role of Vascularized Bone Marrow in Vascularized Composite Allograft Protection

    N. Shockcor, E. Buckingham, W. Hassanein, A. Nam, S. Bartlett, R. Barth.

    Department of Surgery, University of Maryland School of Medicine, Baltimore, MD.

    Purpose: Clinical induction therapies have been demonstrated to interfere with the development of immunologic tolerance in experimental models. Vascularized bone marrow (VBM) has been demonstrated…
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