Articles tagged "Graft failure"

2020 American Transplant Congress
Post-Transplant Hepatic CHOP Expression Dictates Clinical Outcomes in Liver Transplantation
H. Hirao¹, T. Ito¹, K. Nakamura², S. Kageyama¹, K. Kadono¹, H. Kojima¹, K. J. Dery¹, S. Younan¹, R. W. Busuttil¹, F. M. Kaldas¹, J. W. Kupiec‐Weglinski¹
¹UCLA, Los Angeles, CA, ²Kyoto University, Kyoto, Japan
*Purpose: Endoplasmic reticulum (ER) stress plays a pivotal role in the mechanism of liver ischemia reperfusion injury (IRI). Although we and others have demonstrated the…
2020 American Transplant Congress
Evaluating the Effect of HCV Status on the KDPI in the Era of DAA Therapy
J. Husson¹, S. Curreli², B. Ravichandran³, E. Wilson⁴
¹Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, ²Institute of Human Virology, Baltimore, MD, ³University of Maryland Medical Center, University of Maryland School of Pharmacy, Baltimore, MD, ⁴Institue of Human Virology, University of Maryland School of Medicine, Baltimore, MD
*Purpose: The association between KDPI and kidney graft outcomes is limited in the era of DAA therapy.*Methods: We analyzed adult renal transplants, at the University…
2020 American Transplant Congress
Changes in Gut Microbiota and Acute Rejection after Kidney Transplantation
H. Cho¹, J. Kim², H. Kim², J. Park³, M. Kwak⁴, B. Kim⁴, D. Kim², J. Lee⁵, B. Kim⁶, H. Lee²
¹Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea, Republic of, ²Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ³Department of Internal Medicine, Kangwon National University Hospital, Chuncheon, Korea, Republic of, ⁴ChunLab Inc. Seoul National University, Seoul, Korea, Republic of, ⁵Department of Internal Medicine, Seoul National University Boramae Hospital, Seoul, Korea, Republic of, ⁶Department of Life Science, Multidisciplinary Genome Institute, Hallym University, Chuncheon, Korea, Republic of
*Purpose: Kidney transplantation (KT) is the best treatment for end-stage renal disease. Although rejection is a normal immune response of the body to a foreign…
2020 American Transplant Congress
Late Onset Primary Graft Dysfunction after Lung Transplantation Correlates with Transplant Arteriosclerosis in a Humanized Mouse Model
M. Franz¹, T. Siemeni¹, A. Knöfel¹, W. Sommer¹, M. Avsar¹, F. Ius¹, I. Tudorache¹, C. Kühn¹, C. S. Falk², G. Warnecke¹, A. Haverich¹
¹Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany, ²IFB-Tx, Hannover Medical School, Hannover, Germany
*Purpose: Primary Graft dysfunction (PGD) is one of the most important causes of early mortality after lung transplantation. We investigated the correlation between the incidence…
2020 American Transplant Congress
Incidence, Risk Factors, and Kidney Transplant Outcomes Associated with Post-Transplant Diabetes Mellitus
R. F. Malik¹, Y. Jia¹, S. G. Mansour², I. E. Hall², M. D. Doshi², P. P. Reese², P. Singh², M. N. Harhay², F. L. Weng², H. Thiessen Philbrook¹, B. Schröppel², T. Muthukumar², J. S. Bromberg², E. Akalin², S. Mohan², C. R. Parikh¹
¹Johns Hopkins University, Baltimore, MD, ²DDS Consortium, Baltimore, MD
*Purpose: Post-Transplant Diabetes Mellitus (PTDM) is a common complication after kidney transplant (KT). Most prior studies are single-center with short follow-up and inconsistent outcome ascertainment.…
2020 American Transplant Congress
Ranking Eplet Mismatches as Predictors of Graft Failure
W. Zhang¹, H. Mohammadhassanzadeh¹, K. Oualkacha², H. Gebel³, W. Klement⁴, R. Sapir-Pichhadze¹
¹McGill University, Montreal, QC, Canada, ²UQAM, Montreal, QC, Canada, ³Emory University Hospital, Atlanta, GA, ⁴Canadian Blood Services, Ottawa, ON, Canada
*Purpose: Donor:recipient matching at the level of sequence defined HLA targets (eplets) is being promoted as a biologically sound strategy to prevent graft failure. Because…
2020 American Transplant Congress
Incidence and Risks Factors of Kidney Allograft Loss Due to BK Virus in Pediatric Population: UNOS Data Set
H. Patel¹, K. Agrawal¹, A. Pawar¹, N. Rodig², N. Agrawal¹, F. Cardarelli¹
¹Transplant Nephrology, Beth Israel Deaconess Medical Center, Boston, MA, ²Nephrology (Medicine), Boston Children's Hospital, Boston, MA
*Purpose: BK virus infection can lead to graft dysfunction and loss in kidney transplant patients. Incidence and prevalence of BK Viremia (BKV) and BK Virus…
2020 American Transplant Congress
Establishment of Spontaneous Tolerance of Kidney Allografts is Dependent on Mitigation of Ischemia-Reperfusion Injury via the BLTA-HVEM Pathway
Q. Yuan¹, S. Hong¹, E. Szuter¹, Y. Zhao¹, E. Acheampong¹, I. Rosales¹, M. Kronenberg², P. Russell¹, J. Madsen¹, R. Colvin¹, A. Alessandrini¹
¹Massachusetts General Hospital, Boston, MA, ²La Jolla Institute for Allergy & Immunology, La Jolla, CA
*Purpose: Kidney allografts transplanted across certain mouse strain combinations (e.g. DBA/2 to B6) develop tolerance while other combinations do not (e.g. B6 to DBA/2). We…
2020 American Transplant Congress
Long-Term Kidney Graft Survival is Superior with Simultaneous-Liver Kidney (SLK) Transplants Than Kidney Alone (KA) or Kidney after Liver (KALi) Transplants in the United States
N. Lim¹, S. M. Riad¹, S. Jackson², J. Lake¹
¹University of Minnesota, Minneapolis, MN, ²M Health Fairview, Minneapolis, MN
*Purpose: There is a concern that SLK transplant recipients have worse outcomes resulting in poor utilization of the kidney donor pool. We utilized the Scientific…
2020 American Transplant Congress
Low Mycophenolic Acid Levels are Associated with More Inflammation on 1 Year Protocol Biopsies and Lower Graft Survival in Kidney Transplant Recipients
J. Huskey, G. Mour, M. Ryan, S. Nair, M. Smith, R. Heilman
Mayo Clinic Arizona, Phoenix, AZ
*Purpose: Data is limited on the association of Mycophenolic Acid (MPA) concentration on protocol kidney transplant biopsies. Our aim is to compare clinical outcomes and…