ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Graft failure"

  • 2018 American Transplant Congress

    Antiproteinuric Effect of Spironolactone in Renal Transplantation: Effectiveness and Clinical Outcomes

    M. Sousa, C. Do Valle, G. Rivelli, L. Camargo, R. Zollner, M. Mazzali.

    University of Campinas, Campinas, Sao Paulo, Brazil.

    Background: aldosterone is involved in development of fibrosis in kidney transplantation. Blockade of aldosterone receptor appears to be effective in treatment for chronic allograft dysfunction,…
  • 2018 American Transplant Congress

    Evolving Etiologies for Readmissions and Their Impact on Graft Survival in Kidney Transplantation

    D. Taber, N. Pilch, Z. Su, C. Mardis, J. Fleming, N. Patel, H. Meadows, P. Mauldin, V. Rao, D. Dubay.

    MUSC, Charleston, SC.

    Background: Although readmissions after kidney transplant are a well-known risk factor for graft loss, it is unclear if certain etiologies are associated with poorer outcomes…
  • 2018 American Transplant Congress

    The Likelihood of Re-Transplantation in Patients Undergoing Allograft Nephrectomy

    G. Lucisano,1 P. Brookes,2 E. Santos-Nunez,2 N. Firmin,2 N. Gunby,2 S. Hassan,1 A. Gueret-Wardle,1 M. Willicombe,1 D. Taube.1

    1Renal and Transplant Centre, Imperial College Healthcare NHS Trust, London, United Kingdom; 2Histocompatibility and Immunogenetics, Imperial College Healthcare NHS Trust, London, United Kingdom.

    Introduction: transplant nephrectomy (NX) is a known cause of allosensitisation after graft failure. As yet, there is no consensus for the management of the patient…
  • 2018 American Transplant Congress

    Acute Murine CMV Infection Results in Loss of Intragraft CD73HIFR4HIPD1+ CD4 T Cells and Graft Rejection in Previously Tolerant Recipients

    A. Dangi,1 L. Zhang,1 X. Zhang,2 X. Luo.1,2

    1Division of Nephrology and Hypertension, Department of Medicine, Northwestern University, Chicago, IL; 2Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL.

    Background: Transplantation tolerance in human recipients has been achieved in recent trials. Nevertheless, the impact of highly prevalent and clinically relevant cytomegalovirus (CMV) infection on…
  • 2018 American Transplant Congress

    Scoring Transplant Glomerulopathy Using Morphometry: Correlation with Banff Criteria

    M. Morales, A. Denic, W. Park, B. Smith, M. Alexander, M. Stegall.

    William J.von Liebig Transplant Center, Mayo Clinic, Rochester, MN.

    Background: Transplant glomerulopathy (TG) is a prognostic marker for graft survival. Still, scoring TG using the Banff cg-score remains a challenge and no assessments in…
  • 2018 American Transplant Congress

    The Association between Transplant Glomerulopathy and Graft Outcomes among Patients Undergoing Kidney Transplantation: Results of a Meta-Analysis

    G. Kovács,1 G. Devercelli,2 Z. Vokó,1,3 T. Zelei,1 I. Hirji,2 P. Keown.4,5

    1Syreon Research Institute, Budapest, Hungary; 2Shire, Lexington, MA; 3Health Policy & Health Economics, Eötvös Loránd University, Budapest, Hungary; 4Syreon Corporation, Vancouver, BC, Canada; 5University of British Columbia, Vancouver, BC, Canada.

    Transplant glomerulopathy (TG) can lead to irreversible kidney damage. TG is recognized as a surrogate marker for poor outcomes, including graft failure and loss among…
  • 2018 American Transplant Congress

    Relationship between Living Kidney Donor Follow-Up GFR and Recipient Graft Loss

    C. Holscher,1 T. Ishaque,1 C. Haugen,1 S. DiBrito,1 K. Jackson,1 A. Muzaale,1 A. Massie,1,2 M. Henderson,1 J. Garonzik Wang,1 D. Segev.1,2,3

    1Johns Hopkins School of Medicine, Baltimore; 2Johns Hopkins School of Public Health, Baltimore; 3Scientific Registry of Transplant Recipients, Minneapolis.

    In living kidney transplantation, it is reasonable to believe a donated kidney's function would be associated with the function of the donor's remaining kidney. Indeed,…
  • 2018 American Transplant Congress

    Title: Donor-Derived Cell Free DNA Predicts Development of Clinically Significant Changes in Donor Specific Antibody Following Kidney Transplant

    A. Brubaker,1 D. Stoltz,1 M. Grskovic,2 R. Woodward,2 A. Gallo.1

    1Department of Surgery, Division of Abdominal Transplantation, Stanford University, Stanford, CA; 2CareDx, Brisbane, CA.

    Background: Recently, high immunologic risk patients comprise a significant percentage of the total adult renal transplants performed yearly. Surveillance management of these patients and interpretation…
  • 2018 American Transplant Congress

    Standard Induction Immunosuppression Interferes with the Role of Vascularized Bone Marrow in Vascularized Composite Allograft Protection

    N. Shockcor, E. Buckingham, W. Hassanein, A. Nam, S. Bartlett, R. Barth.

    Department of Surgery, University of Maryland School of Medicine, Baltimore, MD.

    Purpose: Clinical induction therapies have been demonstrated to interfere with the development of immunologic tolerance in experimental models. Vascularized bone marrow (VBM) has been demonstrated…
  • 2018 American Transplant Congress

    Everolimus and the Risk of Graft Loss or Death in Kidney Transplant Recipients: A Trial-Based Linkage Study

    T. Ying,1,2 G. Wong, W. Lim, G. Russ, H. Pilmore, J. Kanellis, D. Goodman, P. Trevillian, S. Campbell, M. Suranyi, M. Mathew, R. Faull, R. Masterson, R. Walker, P. O'Connell, S. Chadban.1,2

    1Renal Medicine, Royal Prince Alfred Hospital, Camperdown, Australia; 2Kidney Node, Charles Perkins Centre, University of Sydney, Sydney, Australia.

    Background: The use of mTORIs may be associated with a reduction of cancer incidence after kidney transplantation (KT) and improved graft function compared with calcineurin-inhibitor…
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