Articles tagged "Graft failure"

2019 American Transplant Congress
Association Of Lymphocyte-depleting Antibody And Steroids Induction With The Risk And Outcomes Of Post-transplant Diabetes: Analysis Of Deceased-donor Kidney Transplants
A. Santos¹, J. Gregg², U. L. Akanit³, K. Alquadan¹, H. Bejjanki¹, K. L. Womer¹
¹Div. of Nephrology, Hypertension & Renal Transplantation, University of Florida, Gainesville, FL, ²University of Florida, Gainesville, FL, ³Ubon Ratchathani University, Ubonratchathani, Thailand
*Purpose: We aimed to determine the risk and outcomes of post-transplant diabetes(PTDM) associated with combined lymphocyte-depleting antibody (LDA) [anti-thymocyte globulin (ATG) or alemtuzumab (ALM)] and…
2019 American Transplant Congress
Effect of HLA Mismatch on Recurrence and Graft Loss in Living versus Deceased Kidney Transplant Recipients with IgA Nephropathy
T. Ishaque, F. A. Ammary, K. Jackson, D. L. Segev, A. B. Massie
Johns Hopkins School of Medicine, Baltimore, MD
*Purpose: A registry based study from Australia and New Zealand reported increased risk of recurrent IgA nephropathy (IgAN) in zero-HLA-mismatched living donor kidney transplant (LDKT)…
2019 American Transplant Congress
Beneficial Association between Renin-Angiotensin-Aldosterone-System Blockade Usage and Graft Prognosis in Allograft Immunoglobulin A Nephropathy
S. Park¹, C. Baek², M. Yu³, Y. Kim¹, J. Moon¹, H. Go², Y. Kim², J. Lee⁴, S. Min¹, J. Ha¹, K. Moon¹, Y. Kim¹, C. Ahn¹, S. Park², H. Lee¹
¹Seoul National University Hospital, Seoul, Korea, Republic of, ²Asan Medical Center, Seoul, Korea, Republic of, ³Hanyang University Hospital, Seoul, Korea, Republic of, ⁴Seoul National University Hospital, Boramae Medical Center, Seoul, Korea, Republic of
*Purpose: Although immunoglobulin A nephropathy (IgAN) is associated with a high risk of renal allograft failure, evidences for its treatment, including renin-angiotensin-aldosterone system blockade (RAASB)…
2019 American Transplant Congress
Early Allograft Dysfunction in High Acuity Liver Transplant Recipients
T. Ito, M. Lu, A. Murray, D. S. Graham, J. DiNorcia, V. G. Agopian, H. Yersiz, D. G. Farmer, R. W. Busuttil, F. M. Kaldas
Department of Surgery, The Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Organ recipient matching in Liver Transplantation (LT) has become ever-more challenging with the ongoing organ scarcity and increasing patient acuity. While the notion that…
2019 American Transplant Congress
Patterns of Rejection in Murine, Porcine, and Human Vascularized Composite Allografts Based on Clinical, Histologic, and Immunohistochemical Analysis
M. J. Grzelak, J. W. Etra, F. A. Chang, G. J. Furtmüller, A. R. Ahmadi, F. Nägele, Y. Guo, K. Kambarashvili, A. Jain, S. A. Beck, C. F. Brayton, I. B. Sander, W. A. Lee, G. Brandacher
Plastic and Reconstructive Surgery, Johns Hopkins School of Medicine, Baltimore, MD
*Purpose: The side effects of chronic immunossupression limit the more extensive use of Vascularized Composite Allotransplantation (VCA), and because reliable pre-clinical animal models will be…
2019 American Transplant Congress
Pre-Transplant Transcriptomic Signature in Peripheral Blood Predicts Early Acute Rejection after Kidney Transplant
W. Zhang¹, Z. Yi¹, C. Wei¹, K. Keung², Z. Sun¹, C. Xi¹, C. Woytovich¹, S. Farouk¹, L. Gallon³, M. Menon¹, C. Magee⁴, N. Najafian⁴, M. Samaniego⁵, A. Djamali⁶, S. Alexander², I. Rosales⁷, R. Smith⁷, P. O'Connell², R. Colvin⁷, P. Cravedi¹, B. Murphy¹
¹Icahn School of Medicine at Mount Sinai, New York, NY, ²The University of Sydney, Sydney, Australia, ³Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Brigham and Women's Hospital, Boston, MA, ⁵Henry Ford Hospital, Detroit, MI, ⁶University of Wisconsin, Madison, WI, ⁷Massachusetts General Hospital, Boston, MA
*Purpose: Early development of acute rejection after kidney transplantation is associated with diminished long-term graft survival. Predicting early acute rejection (EAR) at the time of…
2019 American Transplant Congress
Pushing the Limits: A Large Multicentric Case-Control Study Evaluating the Impact of Kidney Transplants from Expanded Criteria Donors after Controlled Circulatory Death the Limits: A Large Multicentric Case-Control Study Evaluating the Impact of Kidney Transplants from Expanded Criteria Donors after Controlled Circulatory Death
N. Toapanta¹, R. Alvarez², G. Lluís³, C. Facundo³, F. Diekmann⁴, I. Revuelta⁴, M. Meneghini², F. Moreso¹, O. Bestard²
¹Kidney Transplantation Unit, Vall d'Hebron University Hospital, Barcelona, Spain, ²Kidney Transplantation Unit, Bellvitge University Hospital- IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain, ³Kidney Transplantation Unit, Puigvert University Hospital, Barcelona, Spain, ⁴Kidney Transplantation Unit, Clinic University Hospital, Barcelona, Spain
*Purpose: Controlled donation after circulatory death (cDCD) has allowed to significantly increase the deceased donors pool. However, while excellent previous reports have been shown using…
2019 American Transplant Congress
Clinical Importance of the Updated Oxford Classification in Allograft IgA Nephropathy
S. Park¹, H. Go², C. Baek², J. Jeong¹, Y. Kim¹, Y. Kim¹, Y. Kim², J. Lee³, S. Min¹, J. Ha¹, E. Song¹, Y. Kim¹, S. Park², K. Moon¹, H. Lee¹
¹Seoul National University Hospital, Seoul, Korea, Republic of, ²Asan Medical Center, Seoul, Korea, Republic of, ³Seoul National University Hospital, Boramae Medical Center, Seoul, Korea, Republic of
*Purpose: An additional investigation on the clinical significance of the updated Oxford classification in allograft IgA nephropathy (IgAN) is warranted.*Methods: We performed a retrospective cohort…
2019 American Transplant Congress
Silent Allograft Fibrosis in 10-Year Post-Transplantation Histology of Pediatric Liver Transplantation: Is It Really Silent?
S. Lee, S. Lee, J. Rhu, Y. Chung, S. Kim, K. Lee, S. Lee, J. Kim, G. Choi , J. Park, S. Kim, J. Joh
Transplantation, Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: This study is designed to analyze factors related to long-term allograft fibrosis in clinically stable pediatric liver transplantation patients.*Methods: Pediatric patients who underwent liver…
2019 American Transplant Congress
Belatacept Monotherapy in Kidney Transplant Recipients with Failed Allografts Reduces Humoral Sensitization in a Single Center Randomized Controlled Trial
I. R. Badell, R. Elbein, R. A. Bray, H. M. Gebel, A. B. Adams, C. P. Larsen
Emory University School of Medicine, Atlanta, GA
*Purpose: Kidney transplant recipients with failed allografts suffer from high rates of humoral sensitization. Immunosuppression (IS) strategies are highly variable in these patients with many…