Session Name: Concurrent Session: Kidney Deceased Donor Allocation III
Date: Tuesday, June 4, 2019
Session Time: 2:30pm-4:00pm
Presentation Time: 3:06pm-3:18pm
Location: Ballroom B
*Purpose: In kidney transplantation, non-immunologic donor-recipient (D-R) pairing is generally not given the same consideration as immunologic matching. The aim of this study was to determine how non-immunologic D-R pairing relates to independent donor and recipient factors, and to immunologic human leukocyte antigen (HLA) match for predicting graft loss.
*Methods: Seven D-R pairings (race, sex, age, weight, height, cytomegalovirus serostatus and HLA match) were assessed for their association with the composite outcome of death or kidney graft loss using a Cox regression-based forward stepwise selection model. The best model for predicting graft loss (including non-immunologic D-R pairings, independent donor/recipient factors, and/or HLA match status) was determined using the Akaike Information Criterion (AIC).
*Results: 23,262 (29.9%) people in the derivation dataset and 9,892 (29.7%) in the validation dataset developed the composite outcome of death or graft loss. A model that included both independent and D-R pairing variables best predicted graft loss. The c-indices for the derivation and validation models were 0.626 and 0.629, respectively. Size mismatch between donor and recipient (> 30 kg (D
To cite this abstract in AMA style:Vinson A, Kiberd B, Davis R, Tennankore K. Non-Immunologic Donor-Recipient Pairing, HLA Matching, and Graft Loss in Deceased Donor Kidney Transplantation [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/non-immunologic-donor-recipient-pairing-hla-matching-and-graft-loss-in-deceased-donor-kidney-transplantation/. Accessed May 5, 2021.
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