Articles tagged "Graft failure"

2020 American Transplant Congress
Kidney Graft Survival by the Teaching Status of a Transplant Center (2008-2019)
K. Maroney, Z. Wang, K. Ross, J. Hogan, R. Patzer
Emory University, Atlanta, GA
*Purpose: Graft survival is an important metric in which transplant centers are graded, yet center-level variation in kidney graft survival still exist after accounting for…
2020 American Transplant Congress
Assessing the Complex Causes of Kidney Allograft Loss
E. Van Loon¹, A. Senev¹, E. Lerut², M. Coemans¹, D. Kuypers¹, M. Emonds¹, M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²KU Leuven, Leuven, Belgium
*Purpose: Although graft loss is a primary endpoint in many studies in kidney transplantation and a broad spectrum of risk factors has been identified, the…
2020 American Transplant Congress
Potential Cost-Savings Associated with ANG-3777 for the Treatment of Delayed Graft Function in Kidney Transplantation
M. Cooper¹, T. Mayne², T. Kauf³, M. Gargano³, K. Freemyer³
¹Medstar Georgetown Transplant Institute, Washington, DC, ²Angion Biomedica Corp, San Francisco, CA, ³Genesis Research, Hoboken, NJ
*Purpose: We created a medical cost offset model based upon the results of a Phase 2, double-blind, randomized controlled trial of ANG-3777, a hepatocyte growth…
2020 American Transplant Congress
Clinical Outcomes Associated with Long-Term Exposure to Airborne Particulate Pollution in Kidney Transplant Recipients
Y. Kim¹, J. Lee²
¹Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ²Internal Medicine, Seoul National University Boramae Hospital, Seoul, Korea, Republic of
*Purpose: We aimed to evaluate the relationship of 10-μm particulate matter (PM10) with the risk of graft failure, mortality, and decline of graft function in…
2020 American Transplant Congress
One Year of COIIN Outcomes: Did Cohorts A and B Maintain Graft Survival?
J. Foutz, R. J. Carrico, K. Sisaithong, H. Tosoc-Haskell, D. Klassen
United Network for Organ Sharing, Richmond, VA
*Purpose: The Collaborative Innovation and Improvement Network (COIIN) was a 3-year OPTN project aimed at increasing the utilization of kidneys with a kidney donor profile…
2020 American Transplant Congress
Association of Kidney Allograft Fibrosis-Associated Proteins with Chronic Lung Allograft Dysfunction
S. Farkona¹, G. Berra², Z. Mohammed-Ali¹, P. Ly², L. Levy², B. Renaud-Picard², G. Zehong², T. Daigneault², S. Juvet², C. McEvoy¹, S. Clotet-Freixas¹, T. Martinu², A. Konvalinka¹
¹Nephrology, Toronto General Hospital Research Institute and Multi-Organ Transplant, University Health Network, Toronto, ON, Canada, ²Lung Transplantation, Toronto Lung Transplant Program, University Health Network, Toronto, ON, Canada
*Purpose: Chronic lung allograft dysfunction (CLAD) remains the leading cause of long-term mortality after lung transplant. Non invasive biomarkers that could assist in early diagnosis…
2020 American Transplant Congress
Early Pancreas Allograft Failure is Associated with Donor Hypertension
C. Masset¹, J. Branchereau¹, L. Badet², C. Kerleau¹, C. Legendre³, D. Glotz⁴, G. Karam¹, D. Cantarovich¹
¹University Hospital of Nantes, Nantes, France, ²University Hospital of Lyon, Lyon, France, ³Necker Hospital, Paris, France, ⁴Saint Louis Hospital, Paris, France
*Purpose: About 10% of pancreas allografts are lost prematurely due to thrombosis. Despite identification of numerous risk factors, the incidence of early failure did not…
2020 American Transplant Congress
Steroid Dependence at 1 Yr in Kidney Transplant Recipients Initiated on Early Steroid Withdrawal Protocol: Associated Risk Factors and Prognosis
M. Yaqub, D. Mishler, T. Taber, A. Sharfuddin, W. Goggins, O. Adebiyi
Indiana University, Indianapolis, IN
*Purpose: Early steroid withdrawal (ESW) has become a stable immunosuppression regimen in the USA with a third of patients now discharged steroid-free immediately post-transplant. However,…
2020 American Transplant Congress
Immune-Mediated Injury and Eplet Mismatches – Profiling Population-Level Interactions
H. Mohammadhassanzadeh¹, W. Zhang², W. Klement³, H. Gebel⁴, P. Keown⁵, K. Oualkacha⁶, R. Sapir-Pichhadze¹
¹Medicine, McGill University, Montreal, QC, Canada, ²McGill University, Montreal, QC, Canada, ³Organ Donation and Transplantation, Canadian Blood Services, Ottawa, ON, Canada, ⁴Emory University Hospital, Atlanta, GA, ⁵Medicine, University of British Columbia, Vancouver, BC, Canada, ⁶Université du Québec À Montréal, Montreal, QC, Canada
*Purpose: HLA genes are in linkage disequilibrium with each other. Sequence defined HLA targets (eplets) are associated with alleles and may be shared within and…
2020 American Transplant Congress
Factors Influencing Background Cell-Free DNA Levels: Implications for Donor-Derived Cell-Free DNA Assessment in Transplant Patients
P. Gauthier, A. Aleshin, S. Shchegrova, T. Mckenna, E. Kalashnikova, S. Sharma, H. Sethi, R. Salari, R. Swenerton, Z. Demko, B. Zimmermann, P. Billings
Natera, Inc., San Carlos, CA
*Purpose: Detecting elevated levels of donor-derived cell-free DNA (dd-cfDNA) in the plasma of transplant recipients has been used as a metric to determine graft injury…