ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Graft acceptance"

  • 2019 American Transplant Congress

    The Collaborative Improvement and Innovation Network (COIIN): Impact on Deceased Donor Transplant Rates and Offer Acceptance Practices

    A. Wey1, S. Gustafson1, B. Carrico2, J. Foutz2, K. Sisaithong3, M. McBride2, D. Klassen2, D. Klassen2, N. Salkowski1, B. Kasiske1, A. Israni1, J. Snyder1

    1SRTR, Minneapolis, MN, 2OPTN, Richmond, VA, 3OPTN, Minneapolis, MN

    *Purpose: The Organ Procurement and Transplantation Network (OPTN) completed the Collaborative Improvement and Innovation Network (COIIN), a study to increase kidney transplants by reducing risk…
  • 2019 American Transplant Congress

    Allogenic Islets Cure Diabetes Following Transplantation in Omental Pouch in a Non-Human Primate Model

    J. Lei1, H. Deng1, K. Lee1, C. Peters1, G. Rickert1, R. Ivy1, M. Coronel2, E. Yolcu3, H. Shirwan4, A. García5, J. Markmann1

    1Surgery, Massachusetts General Hospital, Boston, MA, 2Surgery, Georgia Institute of Technology, Atlanta, GA, 3Institute for Cellular Therapeutics, University of Louisville School of Medicine, louisville, KY, 4Department of Microbiology and Immunology, University of Louisville School of Medicine, louisville, KY, 5School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA

    *Purpose: In the current standard clinical transplant approach, islet cells are administered intravenously into the portal system where they lodge in the liver. This approach…
  • 2019 American Transplant Congress

    Patient Perspectives of Informed Consent for Deceased Donor Organ Intervention Research

    E. Gordon1, B. Knopf1, A. Mussell2, C. Phillips2, R. Veatch3, P. Abt2, P. Reese2

    1Northwestern University, Chicago, IL, 2University of Pennsylvania, Philadelphia, PA, 3Georgetown University, Washington DC, DC

    *Purpose: Interventions on deceased donors or their organs hold promise for increasing the quantity and quality of organs for transplantation by minimizing organ injury and…
  • 2019 American Transplant Congress

    Plasmacytoid Dendritic Cell-Mediated Graft Prolongation Requires microRNA-181 and Semaphorin 4a

    J. Harden, X. Qi, A. Lau, S. Krams

    Stanford Univ School of Med, Stanford, CA

    *Purpose: Dendritic cells (DCs) are antigen-presenting cells (APCs) important for initiating and coordinating the immune response. Plasmacytoid dendritic cells (pDCs) are a subset of DCs…
  • 2019 American Transplant Congress

    Conceptual Extension of SNP Based Abundance Profiling to Infer Donor Derived Cell-Free DNA Fraction as an Indication of Organ Rejection

    R. Sinha, K. Mickey, J. Grantham, M. Wissel, M. Altrich, S. Kleiboeker

    R&D, Viracor-Eurofins, Lee's Summit, MO

    *Purpose: Rejection is a major post-transplant complication for organ transplant recipients. Biopsy remains the standard to diagnose rejection, but other non-invasive methods, such as transcript…
  • 2019 American Transplant Congress

    AMD3100 (Plerixafor) as a Single-Dose Stem Cell Mobilizing Agent in Vascularized Composite Tissue Allograft (VCA) Transplantation in a Canine DLA-Mismatch Model

    B. Swearingen1, S. Graves2, R. Storb2, D. W. Mathes1

    1University of Colorado School of Medicine, Aurora, CO, 2Fred Hutchinson Cancer Research Center, Seattle, WA

    *Purpose: Vascularized Composite Allograft (VCA) transplantation is a clinical reality but limited by toxicities of chronic immunosuppression and rejection. Current clinical tolerance protocols rely on…
  • 2018 American Transplant Congress

    Antiviral Therapy for Donor-Derived Hepatitis C Virus Infection after Solid Organ Transplantation

    A. Kwong,1 A. Wall,2 M. Melcher,2 U. Wang,3 A. Ahmed,1 K. Khush,3 A. Subramanian,3 J. Tan,3 P. Kwo.1

    1Gastroenterology and Hepatology, Stanford University, Palo Alto, CA; 2Surgery, Stanford University, Palo Alto, CA; 3Stanford University, Palo Alto, CA.

    Background: In the context of organ shortage, the opioid epidemic, and the advent of effective direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV), more…
  • 2018 American Transplant Congress

    Kidney Allografts Confer Tolerance upon Co-Transplanted Heart Allografts by Promoting Tregs

    C. Yang,1 T. Ashry,1 I. Rosales,2 J. Ge,1 T. O'Shea,1 R. White,2 P. Russell,1 J. Madsen,1 R. Colvin,2 A. Alessandrini.1

    1Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston; 2Department of Pathology, Massachusetts General Hospital, Boston.

    The same mixed chimerism-based protocol that induces tolerance of nonhuman primate kidney allografts results in rejection of heart allografts. However, when the two organs from…
  • 2018 American Transplant Congress

    Use of Public Health Service Increased Risk Kidneys in Pediatric Renal Transplant Recipients: Recipient Characteristics

    M. Meyers,1 J. Shults,1 B. Laskin,1 P. Porrett,2 M. Levine,2 P. Abt,2 S. Amaral,1,2 D. Goldberg.1

    1Children's Hospital of Philadelphia, Philadelphia; 2University of Pennsylvania, Philadelphia.

    Purpose: The number of donors labeled as Public Health Service Increased Risk (IR) is rising. This designation identifies organs from donors at 'increased risk' of…
  • 2018 American Transplant Congress

    Utilization of Public Health Service Increased Risk Kidneys in Pediatric Renal Transplant Recipients by Era

    M. Meyers,1 J. Shults,1 B. Laskin,1 P. Porrett,2 M. Levine,2 P. Abt,2 S. Amaral,1,2 D. Goldberg.2

    1Children's Hospital of Philadelphia, Philadelphia; 2University of Pennsylvania, Philadelphia.

    Purpose: Donors labeled Public Health Service Increased Risk (PHS-IR) continue to rise due to opioid abuse and expanding criteria defining 'increased-risk.' Many PHS-IR donors are…
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