2019 American Transplant Congress
Pediatric Liver Transplantation during the Opioid Epidemic: UNOS Analysis of Organ Availability and Outcomes
*Purpose: The opioid epidemic has been largely responsible for the 3-fold increase in deaths due to drug overdose over the last 15 years. Whether this…2019 American Transplant Congress
Kidney & Pancreas Transplant Waitlist Management – A Tiered System Approach
Transplant, UCI Health, Orange, CA
*Purpose: Developed and implemented an innovative kidney & pancreas transplant waitlist management system in order to more effectively and efficiently re-evaluate patients on a transplant…2019 American Transplant Congress
Ablation of Interferon Regulatory Factor 4 in T Cells Induces “Memory” of Transplant Tolerance That is Irreversible by Immune Checkpoint Blockade
*Purpose: Achieving alloantigen-specific transplant tolerance through ablation of interferon regulatory factor 4 in T cells*Methods: 1. Irf4fl/flCD4-Cre recipients were first transplanted with BALB/c hearts and…2019 American Transplant Congress
B Cell-Specific IRE1a Deficiency Protects Renal Allografts from Rejection via Inhibition of Donor-Specific Antibodies and Induction of B Regulatory Cells
*Purpose: Despite the progress in immunosuppressive regimens, antibody-mediated rejection remains a major contributor to renal allograft loss in recipients with donor-specific antibodies (DSA). IRE1a, an…2019 American Transplant Congress
Superiority of Donor-Specifically vs. Polyclonally Expanded Regulatory T Cells in Controlling Graft Rejection in the NSG Mouse Human Skin Graft Model
*Purpose: Naturally occurring CD4+CD25highFOXP3+ Regulatory T cells (Tregs) function as mediators of immune homeostasis. So, they are beginning to be utilized for controlling hyper-immunity and…2019 American Transplant Congress
Machine Perfusion Allows Use of High KDPI and Prolonged Cold Ischemia Time in Deceased Donors: A Single Center Effort to Decrease Discard Rates
Miami Transplant Institute, University of Miami, Miami, FL
*Purpose: Discard rates of deceased donor kidney transplants(DDKT)rises as the kidney donor profile index(KDPI)increases,and approaches 60%for KDPI of >85%.Pulsatile machine perfusion(MP)allows use of kidneys with…2019 American Transplant Congress
The Collaborative Improvement and Innovation Network (COIIN): Impact on Deceased Donor Transplant Rates and Offer Acceptance Practices
1SRTR, Minneapolis, MN, 2OPTN, Richmond, VA, 3OPTN, Minneapolis, MN
*Purpose: The Organ Procurement and Transplantation Network (OPTN) completed the Collaborative Improvement and Innovation Network (COIIN), a study to increase kidney transplants by reducing risk…2019 American Transplant Congress
Allogenic Islets Cure Diabetes Following Transplantation in Omental Pouch in a Non-Human Primate Model
*Purpose: In the current standard clinical transplant approach, islet cells are administered intravenously into the portal system where they lodge in the liver. This approach…2019 American Transplant Congress
Patient Perspectives of Informed Consent for Deceased Donor Organ Intervention Research
*Purpose: Interventions on deceased donors or their organs hold promise for increasing the quantity and quality of organs for transplantation by minimizing organ injury and…2019 American Transplant Congress
Plasmacytoid Dendritic Cell-Mediated Graft Prolongation Requires microRNA-181 and Semaphorin 4a
Stanford Univ School of Med, Stanford, CA
*Purpose: Dendritic cells (DCs) are antigen-presenting cells (APCs) important for initiating and coordinating the immune response. Plasmacytoid dendritic cells (pDCs) are a subset of DCs…
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