Articles tagged "Graft acceptance"

2020 American Transplant Congress
Defining the Psychological Profile of Living Organ Donors Using Personality Assessment Inventory
W. T. Branagan¹, S. Huett¹, M. Grafals², W. E. Jackson³, E. A. Pomfret⁴
¹Division of Psychiatry, University of Colorado, Aurora, CO, ²Division of Renal Diseases and Hypertension, University of Colorado, Aurora, CO, ³Division of Gastroenterology and Hepatology, University of Colorado, Aurora, CO, ⁴Division of Transplant Surgery, University of Colorado, Aurora, CO
*Purpose: We aim to assess the psychological profile of living organ donors using normative referenced psychological assessment of personality and pathology.*Methods: Evaluation for living kidney…
2020 American Transplant Congress
Change in the Willingness of Transplant Candidates to Accept Hepatitis C Virus Positive Deceased Donor Organs in the Era of Direct-Acting Antivirals
Q. Yuan, S. Hong, E. Roth, M. Sise, E. Bethea, W. Williams, H. Yeh, N. Elias
Transplant Center, Massachusetts General Hospital，Harvard Medical School, Boston, MA
*Purpose: Direct-acting antiviral (DAA) medications’ advent in 2014 very effectively changed the hepatitis C virus (HCV) treatment landscape and allowed post-transplant HCV therapy. We aimed…
2020 American Transplant Congress
Transplanting Livers from Hepatitis C Virus Positive Donors; Is it Worth the Risk?
J. W. Mensink¹, B. Van Hoek², B. Schaefer³, M. D. Van Rosmalen⁴, I. P. Alwayn⁵, A. E. Braat⁵
¹Leiden University Medical Center, Leiden, Netherlands, ²Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, Netherlands, ³Dutch Transplant Foundation, Leiden, Netherlands, ⁴Eurotransplant International Foundation, Leiden, Netherlands, ⁵Transplant Surgery, Leiden University Medical Center, Leiden, Netherlands
*Purpose: Before the introduction of Direct-Acting Antivirals (DAAs), only selected organs from Hepatitis C virus (HCV) positive donors were successfully transplanted into HCV positive recipients.…
2020 American Transplant Congress
Survey of Clinician Opinions on Use of Organ Transplants from Hepatitis C Virus Positive Donors: Identifying & Overcoming Barriers
K. Lentine¹, T. Alhamad², D. Peipert³, Y. Caliskan¹, B. Concepcion⁴, R. Forbes⁴, M. Schnitzler¹, Z. Zhang¹, S. Chang², M. Cooper⁵, R. Bloom⁶, R. Mannon⁷, D. Axelrod⁸
¹Saint Louis U, Saint Louis, MO, ²Washington U, Saint Louis, MO, ³Northwestern, Chicago, IL, ⁴Vanderbilt, Nashville, TN, ⁵Georgetown, Washington, DC, ⁶U Penn, Philadelphia, MO, ⁷UAB, Birmingham, AL, ⁸U Iowa, Iowa City, IA
*Purpose: Increasing the use of Hepatitis C Virus (HCV) viremic (Nucleic Acid Testing (NAT)+) donor organs for HCV uninfected (HCV-) patients is a potential approach…
2020 American Transplant Congress
Mechanisms by Which Donor Bone-Marrow CXCR4+ Foxp3+ Tregs Promote Long-Term Survival of Murine Limb Allografts
L. Wang¹, Z. Wang², R. Han¹, A. Samanta¹, G. Ge¹, L. S. Levin¹, M. H. Levine¹, W. W. Hancock³
¹Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA, ³Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA
*Purpose: Vascularized composite allotransplantation (VCA) allows tissue replacement after devastating loss but is currently limited in application and may be more widely performed if maintenance…
2020 American Transplant Congress
Effect of DSA-Free Heart Allocation
V. Patel¹, M. Skeans², T. Cascino¹, R. Davies³, M. Colvin¹
¹University of Michigan, Ann Arbor, MI, ²SRTR, Minneapolis, MN, ³UT Southwestern, Dallas, TX
*Purpose: Currently, donation service area (DSA) is the first geographic unit for heart allocation, which creates discrepancies in access for high-urgency candidates. We studied the…
2020 American Transplant Congress
Building Kidneys from Stem Cells for Transplantation
I. M. Rogers¹, J. Whiteley², T. Chow², T. Bongolan², L. Mazilescu³, P. Urbanellis³, S. Ganesh³, M. Selzner³
¹Physiology, University of Toronto, Toronto, ON, Canada, ²LTRI-Sinai Health System, Toronto, ON, Canada, ³MOTU, University Health Network, Toronto, ON, Canada
*Purpose: Our vision is to build a human kidney by combining human stem cells with porcine kidney extracellular matrix.*Methods: Kidneys were decellularized followed by repopulation…
2020 American Transplant Congress
Suppressing Laminin Alpha5 Creates Tolerogenic Niches for Allograft Survival
L. Li¹, M. Shirkey¹, W. Piao¹, Y. Xiong¹, V. Saxena¹, T. Zhang¹, C. Paluskievicz¹, J. Zhao², R. Abdi², J. S. Bromberg¹
¹UMB, Baltimore, MD, ²Harvard University, Boston, MA
*Purpose: Laminin α5 (Lama5) regulates CD4 T cell migration and function. We hypothesized that stromal Lama5 regulates the structure of the lymph node (LN) microenvironment…
2020 American Transplant Congress
Electroacupuncture Promotes Induction of Long-Term Allograft Survival by Enhancing Lymphatic Migration of CD4+Foxp3+ Tregs via Upregulating Their LTalpha1beta2 Expression
H. Liu, Y. Chen, F. Qiu, Z. Dai
Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
*Purpose: Induction of long-term transplant survival without continuous global immunosuppression is a highly desired goal in transplantation. Electroacupuncture (EA) has been shown to regulate immunity…
2019 American Transplant Congress
Impact of Discards for Living Donor Kidney Transplantation in Center Transplant Program
H. Villafuerte¹, E. De Sousa-Amorim², L. Peri³, M. Musquera³, E. Palou⁴, M. Lozano⁵, J. Cid⁵, J. Martorell⁴, J. M. Campistol², F. Oppenheimer², F. Diekmann², I. Revuelta²
¹Department of Nephrology, Hospital Clinic Lozano Blesa, Zaragoza, Spain, ²Department of Nephrology and Kidney Transplant, Hospital Clinic, Barcelona, Spain, ³Department of Urology, Hospital Clinic, Barcelona, Spain, ⁴Department of Immunology, Hospital Clinic, Barcelona, Spain, ⁵Department of Apheresis, Hospital Clinic, Barcelona, Spain
*Purpose: New and coming information about the risk of living kidney donors make the effort to study very carefully the option of living kidney donor…

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