ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Graft acceptance"

  • 2021 American Transplant Congress

    Allograft Discard Risk Index for Heart Transplantation

    R. M. Reul1, A. A. Saleem1, C. N. Keller1, T. H. Malik1, J. A. Goss2, A. A. Rana2

    1Office of Student Affairs, Baylor College of Medicine, Houston, TX, 2Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX

    *Purpose: The number of patients awaiting heart transplantation (HTx) substantially exceeds the number of donor hearts transplanted each year, yet nearly 70% of consented donor…
  • 2021 American Transplant Congress

    Outcomes of Simultaneous Pancreas-Kidney Transplants from Donation After Circulatory Death Donors in the UK: A National Registry Analysis

    N. Karydis1, M. Ibrahim2, C. Counter2, J. Casey3, P. Friend4, C. Watson5, C. Callaghan1

    1Nephrology and Transplantation, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom, 2NHS Blood and Transplant, Bristol, United Kingdom, 3Transplant Unit, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom, 4Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, 5Department of Surgery, Addenbrooke's Hospital and Cambridge NIHR Biomedical Research Campus, Cambridge, United Kingdom

    *Purpose: The UK is a world leader in the use of pancreases from donation after circulatory death (DCD) donors. However, there is a perception that…
  • 2021 American Transplant Congress

    Can Procurement Biopsy Data Tell Us Anything? The Influence of Glomerulosclerosis on Long-term Kidney Graft Survival

    D. Stewart1, L. Kamal2, J. Foutz3, H. McGehee3, P. Saravanane2, S. Yu2, R. Yousfi2, G. Gupta2

    1United Network for Organ Sharing, Richmond, VA, 2Virginia Commonwealth University Health, Richmond, VA, 3Research, United Network for Organ Sharing, Richmond, VA

    *Purpose: Biopsy findings, particularly % glomerulosclerosis, have been shown to have a profound impact on kidney utilization decisions. Most studies of the association between procurement…
  • 2021 American Transplant Congress

    Findings from the Bareto Study: Associations Between Chronic Vascular Changes and 10-year Transplant Graft Outcomes

    L. Kamal1, D. Stewart2, J. Foutz2, H. McGehee2, P. Saravanane1, S. Yu1, R. Yusfi1, G. Gupta1

    1Virginia Commonwealth University, Richmond, VA, 2UNOS, Richmond, VA

    *Purpose: As part of a broader study on Biopsy, Anatomy, and Resistance Effects on Transplant Outcomes (BARETO), we aim to characterize the poorly understood relationship…
  • 2021 American Transplant Congress

    Increased T Cell Cross-dressing in Accepted Kidney Allografts

    Q. Yuan1, S. Hong2, E. Szuter2, I. Rosales2, Y. Zhao2, B. Gonzalez-Nolasco2, G. Benichou2, P. Russell2, J. Madsen2, R. Colvin2, A. Alessandrini2

    1Massachusetts General Hospital/Chinese PLA General Hospital, Boston, MA, 2Massachusetts General Hospital, Boston, MA

    *Purpose: Kidney allografts transplanted across certain mouse strain combinations (e.g. DBA/2 to B6) develop tolerance while other combinations do not (e.g. B6 to DBA/2). We…
  • 2021 American Transplant Congress

    Laminin Alpha 4 and Alpha5 Differentially Regulate Lymph Node Tolerogenic Structure

    L. Li1, M. Shirkey1, W. Piao1, Y. Xiong1, V. Saxena1, T. Zhang1, J. Iyyathurai2, R. Lakhan1, R. Abdi3, J. Bromberg1

    1Surgery, UMB, Baltimore, MD, 2CVID, UMB, Baltimore, MD, 3Harvard University, Boston, MD

    *Purpose: Lymph node (LN) stromal laminins α4 (Lama4) and α5 (Lama5) are associated with tolerance and immunity, respectively. We hypothesized that stromal Lama4 and Lama5…
  • 2020 American Transplant Congress

    Cardiac Allograft Tolerance Can be Achieved in Non-Human Primates via Transient Mixed Hematopoietic Chimerism and Erythropoietin Administration

    K. Ahrens1, J. M. O1, W. Sommer2, J. Morrissette1, D. Becerra1, P. M. Patel1, A. Dehnadi1, T. Costa1, I. M. Hanekamp1, J. S. Allan3, P. Cravedi4, P. S. Heeger4, G. Benichou1, J. C. Madsen5

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany, 3Center for Transplantation Sciences, Division of Thoracic Surgery, Massachusetts General Hospital, Boston, MA, 4Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, 5Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA

    *Purpose: In non-human primates (NHPs), a mixed chimerism-based conditioning protocol results in kidney transplant tolerance and combined kidney and heart allograft tolerance. Previous work showed…
  • 2020 American Transplant Congress

    Gross Morphological Score for Deceased Donor Kidneys Can Predict Delayed Graft Function in Kidney Transplant Recipients

    M. Mandurah, M. A. Levine, A. Sener, P. Luke

    Department of Kidney Transplantation, London Health Sciences Center, London, ON, Canada

    *Purpose: Both microscopy and kidney donor profile index (KDPI) scoring systems have been used to predict kidney transplant outcomes. Utilizing gross renal morphology, we designed…
  • 2020 American Transplant Congress

    Dual Kidney Transplantation Offers a Safe and Effective Way to Use Kidneys from Deceased Donors Older Than 70 Years

    K. Lee, J. Park, S. Cha, M. Kim

    Samsung Medical Center, Seoul, Korea, Republic of

    *Purpose: Dual kidney transplantation (DKT) offers a way to extend the use of kidneys from expanded criteria donors (ECDs). Here, we compared the outcomes of…
  • 2020 American Transplant Congress

    The Impact of Occult Graft Fibrosis on Clinical Outcomes in Human Liver Transplant Recipients

    H. Hirao1, T. Ito1, B. V. Naini1, K. Nakamura2, S. Kageyama1, K. Kadono1, H. Kojima1, K. J. Dery1, S. Younan1, F. M. Kaldas1, R. W. Busuttil1, J. W. Kupiec-Weglinski1

    1UCLA, Los Angeles, CA, 2Kyoto University, Kyoto, Japan

    *Purpose: Although liver transplantation (LT) has become a standard therapy for end-stage liver disease, early allograft dysfunction (EAD) and graft rejection remain serious unsolved problems.…
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