Articles tagged "Graft acceptance"

2021 American Transplant Congress
Allograft Discard Risk Index for Heart Transplantation
R. M. Reul¹, A. A. Saleem¹, C. N. Keller¹, T. H. Malik¹, J. A. Goss², A. A. Rana²
¹Office of Student Affairs, Baylor College of Medicine, Houston, TX, ²Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX
*Purpose: The number of patients awaiting heart transplantation (HTx) substantially exceeds the number of donor hearts transplanted each year, yet nearly 70% of consented donor…
2021 American Transplant Congress
Outcomes of Simultaneous Pancreas-Kidney Transplants from Donation After Circulatory Death Donors in the UK: A National Registry Analysis
N. Karydis¹, M. Ibrahim², C. Counter², J. Casey³, P. Friend⁴, C. Watson⁵, C. Callaghan¹
¹Nephrology and Transplantation, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom, ²NHS Blood and Transplant, Bristol, United Kingdom, ³Transplant Unit, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom, ⁴Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ⁵Department of Surgery, Addenbrooke's Hospital and Cambridge NIHR Biomedical Research Campus, Cambridge, United Kingdom
*Purpose: The UK is a world leader in the use of pancreases from donation after circulatory death (DCD) donors. However, there is a perception that…
2021 American Transplant Congress
Can Procurement Biopsy Data Tell Us Anything? The Influence of Glomerulosclerosis on Long-term Kidney Graft Survival
D. Stewart¹, L. Kamal², J. Foutz³, H. McGehee³, P. Saravanane², S. Yu², R. Yousfi², G. Gupta²
¹United Network for Organ Sharing, Richmond, VA, ²Virginia Commonwealth University Health, Richmond, VA, ³Research, United Network for Organ Sharing, Richmond, VA
*Purpose: Biopsy findings, particularly % glomerulosclerosis, have been shown to have a profound impact on kidney utilization decisions. Most studies of the association between procurement…
2021 American Transplant Congress
Findings from the Bareto Study: Associations Between Chronic Vascular Changes and 10-year Transplant Graft Outcomes
L. Kamal¹, D. Stewart², J. Foutz², H. McGehee², P. Saravanane¹, S. Yu¹, R. Yusfi¹, G. Gupta¹
¹Virginia Commonwealth University, Richmond, VA, ²UNOS, Richmond, VA
*Purpose: As part of a broader study on Biopsy, Anatomy, and Resistance Effects on Transplant Outcomes (BARETO), we aim to characterize the poorly understood relationship…
2021 American Transplant Congress
Increased T Cell Cross-dressing in Accepted Kidney Allografts
Q. Yuan¹, S. Hong², E. Szuter², I. Rosales², Y. Zhao², B. Gonzalez-Nolasco², G. Benichou², P. Russell², J. Madsen², R. Colvin², A. Alessandrini²
¹Massachusetts General Hospital/Chinese PLA General Hospital, Boston, MA, ²Massachusetts General Hospital, Boston, MA
*Purpose: Kidney allografts transplanted across certain mouse strain combinations (e.g. DBA/2 to B6) develop tolerance while other combinations do not (e.g. B6 to DBA/2). We…
2021 American Transplant Congress
Laminin Alpha 4 and Alpha5 Differentially Regulate Lymph Node Tolerogenic Structure
L. Li¹, M. Shirkey¹, W. Piao¹, Y. Xiong¹, V. Saxena¹, T. Zhang¹, J. Iyyathurai², R. Lakhan¹, R. Abdi³, J. Bromberg¹
¹Surgery, UMB, Baltimore, MD, ²CVID, UMB, Baltimore, MD, ³Harvard University, Boston, MD
*Purpose: Lymph node (LN) stromal laminins α4 (Lama4) and α5 (Lama5) are associated with tolerance and immunity, respectively. We hypothesized that stromal Lama4 and Lama5…
2020 American Transplant Congress
Cardiac Allograft Tolerance Can be Achieved in Non-Human Primates via Transient Mixed Hematopoietic Chimerism and Erythropoietin Administration
K. Ahrens¹, J. M. O¹, W. Sommer², J. Morrissette¹, D. Becerra¹, P. M. Patel¹, A. Dehnadi¹, T. Costa¹, I. M. Hanekamp¹, J. S. Allan³, P. Cravedi⁴, P. S. Heeger⁴, G. Benichou¹, J. C. Madsen⁵
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany, ³Center for Transplantation Sciences, Division of Thoracic Surgery, Massachusetts General Hospital, Boston, MA, ⁴Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, ⁵Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: In non-human primates (NHPs), a mixed chimerism-based conditioning protocol results in kidney transplant tolerance and combined kidney and heart allograft tolerance. Previous work showed…
2020 American Transplant Congress
Gross Morphological Score for Deceased Donor Kidneys Can Predict Delayed Graft Function in Kidney Transplant Recipients
M. Mandurah, M. A. Levine, A. Sener, P. Luke
Department of Kidney Transplantation, London Health Sciences Center, London, ON, Canada
*Purpose: Both microscopy and kidney donor profile index (KDPI) scoring systems have been used to predict kidney transplant outcomes. Utilizing gross renal morphology, we designed…
2020 American Transplant Congress
Dual Kidney Transplantation Offers a Safe and Effective Way to Use Kidneys from Deceased Donors Older Than 70 Years
K. Lee, J. Park, S. Cha, M. Kim
Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: Dual kidney transplantation (DKT) offers a way to extend the use of kidneys from expanded criteria donors (ECDs). Here, we compared the outcomes of…
2020 American Transplant Congress
The Impact of Occult Graft Fibrosis on Clinical Outcomes in Human Liver Transplant Recipients
H. Hirao¹, T. Ito¹, B. V. Naini¹, K. Nakamura², S. Kageyama¹, K. Kadono¹, H. Kojima¹, K. J. Dery¹, S. Younan¹, F. M. Kaldas¹, R. W. Busuttil¹, J. W. Kupiec-Weglinski¹
¹UCLA, Los Angeles, CA, ²Kyoto University, Kyoto, Japan
*Purpose: Although liver transplantation (LT) has become a standard therapy for end-stage liver disease, early allograft dysfunction (EAD) and graft rejection remain serious unsolved problems.…