Articles tagged "Graft acceptance"

2021 American Transplant Congress
Laminin Alpha 4 and Alpha5 Differentially Regulate Lymph Node Tolerogenic Structure
L. Li¹, M. Shirkey¹, W. Piao¹, Y. Xiong¹, V. Saxena¹, T. Zhang¹, J. Iyyathurai², R. Lakhan¹, R. Abdi³, J. Bromberg¹
¹Surgery, UMB, Baltimore, MD, ²CVID, UMB, Baltimore, MD, ³Harvard University, Boston, MD
*Purpose: Lymph node (LN) stromal laminins α4 (Lama4) and α5 (Lama5) are associated with tolerance and immunity, respectively. We hypothesized that stromal Lama4 and Lama5…
2021 American Transplant Congress
Increased T Cell Cross-dressing in Accepted Kidney Allografts
Q. Yuan¹, S. Hong², E. Szuter², I. Rosales², Y. Zhao², B. Gonzalez-Nolasco², G. Benichou², P. Russell², J. Madsen², R. Colvin², A. Alessandrini²
¹Massachusetts General Hospital/Chinese PLA General Hospital, Boston, MA, ²Massachusetts General Hospital, Boston, MA
*Purpose: Kidney allografts transplanted across certain mouse strain combinations (e.g. DBA/2 to B6) develop tolerance while other combinations do not (e.g. B6 to DBA/2). We…
2020 American Transplant Congress
Dual Kidney Transplantation Offers a Safe and Effective Way to Use Kidneys from Deceased Donors Older Than 70 Years
K. Lee, J. Park, S. Cha, M. Kim
Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: Dual kidney transplantation (DKT) offers a way to extend the use of kidneys from expanded criteria donors (ECDs). Here, we compared the outcomes of…
2020 American Transplant Congress
The Impact of Occult Graft Fibrosis on Clinical Outcomes in Human Liver Transplant Recipients
H. Hirao¹, T. Ito¹, B. V. Naini¹, K. Nakamura², S. Kageyama¹, K. Kadono¹, H. Kojima¹, K. J. Dery¹, S. Younan¹, F. M. Kaldas¹, R. W. Busuttil¹, J. W. Kupiec-Weglinski¹
¹UCLA, Los Angeles, CA, ²Kyoto University, Kyoto, Japan
*Purpose: Although liver transplantation (LT) has become a standard therapy for end-stage liver disease, early allograft dysfunction (EAD) and graft rejection remain serious unsolved problems.…
2020 American Transplant Congress
Geographic Discard Disparities of Liver Allografts
P. I. Kenny Jr¹, A. Rana², J. Vierling²
¹Medical Student, Baylor College of Medicine, Houston, TX, ²Baylor College of Medicine, Houston, TX
*Purpose: The aim of this study is to demonstrate the significant geographic disparity in liver allograft discard.*Methods: Using the OPTN Diseased Donor Network database, we…
2020 American Transplant Congress
Predicting Kidney Allograft Discard: The Kidney Discard Risk Index
M. B. Price, M. Joshi, T. Zhang, J. Vierling, T. Galvan, R. Cotton, C. O'Mahony, J. Goss, A. Rana
Michael E. DeBakey Department of Surgery, Division of Abdominal Transplantation, Baylor College of Medicine, Houston, TX
*Purpose: The disparity between the supply and demand for kidney allografts is exacerbated by an 18.9% discard rate. It is our aim to determine predictors…
2020 American Transplant Congress
Report of Organ Offers Linked with Instant Messaging Data Provides a Basis for Quality Improvement
E. Pahl
Health Informatics, University of Iowa, Iowa City, IA
*Purpose: Thousands of viable organs are discarded every year with incorrect or inappropriate reasons for declination. One limitation on the accessibility of organ transplantation is…
2020 American Transplant Congress
Trends in Transplant Center Responses to the Minimum Acceptance Criteria Across UNOS Regions, 2007-2019
E. M. Roth¹, Q. Yuan², N. Elias²
¹Harvard Medical School, Boston, MA, ²Transplant Center, Massachusetts General Hospital, Boston, MA
*Purpose: The objective of this study was to examine trends in transplant center willingness to accept organs from Public Health Service increased-risk donors for infectious…
2020 American Transplant Congress
Defining the Psychological Profile of Living Organ Donors Using Personality Assessment Inventory
W. T. Branagan¹, S. Huett¹, M. Grafals², W. E. Jackson³, E. A. Pomfret⁴
¹Division of Psychiatry, University of Colorado, Aurora, CO, ²Division of Renal Diseases and Hypertension, University of Colorado, Aurora, CO, ³Division of Gastroenterology and Hepatology, University of Colorado, Aurora, CO, ⁴Division of Transplant Surgery, University of Colorado, Aurora, CO
*Purpose: We aim to assess the psychological profile of living organ donors using normative referenced psychological assessment of personality and pathology.*Methods: Evaluation for living kidney…
2020 American Transplant Congress
Change in the Willingness of Transplant Candidates to Accept Hepatitis C Virus Positive Deceased Donor Organs in the Era of Direct-Acting Antivirals
Q. Yuan, S. Hong, E. Roth, M. Sise, E. Bethea, W. Williams, H. Yeh, N. Elias
Transplant Center, Massachusetts General Hospital，Harvard Medical School, Boston, MA
*Purpose: Direct-acting antiviral (DAA) medications’ advent in 2014 very effectively changed the hepatitis C virus (HCV) treatment landscape and allowed post-transplant HCV therapy. We aimed…