Articles tagged "Graft acceptance"

2020 American Transplant Congress
Mechanisms by Which Donor Bone-Marrow CXCR4+ Foxp3+ Tregs Promote Long-Term Survival of Murine Limb Allografts
L. Wang¹, Z. Wang², R. Han¹, A. Samanta¹, G. Ge¹, L. S. Levin¹, M. H. Levine¹, W. W. Hancock³
¹Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA, ³Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA
*Purpose: Vascularized composite allotransplantation (VCA) allows tissue replacement after devastating loss but is currently limited in application and may be more widely performed if maintenance…
2020 American Transplant Congress
Effect of DSA-Free Heart Allocation
V. Patel¹, M. Skeans², T. Cascino¹, R. Davies³, M. Colvin¹
¹University of Michigan, Ann Arbor, MI, ²SRTR, Minneapolis, MN, ³UT Southwestern, Dallas, TX
*Purpose: Currently, donation service area (DSA) is the first geographic unit for heart allocation, which creates discrepancies in access for high-urgency candidates. We studied the…
2020 American Transplant Congress
Building Kidneys from Stem Cells for Transplantation
I. M. Rogers¹, J. Whiteley², T. Chow², T. Bongolan², L. Mazilescu³, P. Urbanellis³, S. Ganesh³, M. Selzner³
¹Physiology, University of Toronto, Toronto, ON, Canada, ²LTRI-Sinai Health System, Toronto, ON, Canada, ³MOTU, University Health Network, Toronto, ON, Canada
*Purpose: Our vision is to build a human kidney by combining human stem cells with porcine kidney extracellular matrix.*Methods: Kidneys were decellularized followed by repopulation…
2020 American Transplant Congress
Suppressing Laminin Alpha5 Creates Tolerogenic Niches for Allograft Survival
L. Li¹, M. Shirkey¹, W. Piao¹, Y. Xiong¹, V. Saxena¹, T. Zhang¹, C. Paluskievicz¹, J. Zhao², R. Abdi², J. S. Bromberg¹
¹UMB, Baltimore, MD, ²Harvard University, Boston, MA
*Purpose: Laminin α5 (Lama5) regulates CD4 T cell migration and function. We hypothesized that stromal Lama5 regulates the structure of the lymph node (LN) microenvironment…
2020 American Transplant Congress
Electroacupuncture Promotes Induction of Long-Term Allograft Survival by Enhancing Lymphatic Migration of CD4+Foxp3+ Tregs via Upregulating Their LTalpha1beta2 Expression
H. Liu, Y. Chen, F. Qiu, Z. Dai
Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
*Purpose: Induction of long-term transplant survival without continuous global immunosuppression is a highly desired goal in transplantation. Electroacupuncture (EA) has been shown to regulate immunity…
2020 American Transplant Congress
Immunomodulation with FasL Presenting Biomaterials Achieves Long-Term Survival of Allogeneic Islets in the Absence of Chronic Immunosuppression in a Non-Human Primate Model
J. Lei¹, H. Deng¹, T. Chen¹, K. Lee¹, C. Peters¹, Z. Yang¹, K. Deng¹, G. Rickert¹, I. Rosales¹, N. Serifis¹, M. Coronel², M. Hunckler², E. Yolcu³, H. Shirwan³, A. García², J. Markmann¹
¹Surgery, Mass General, Boston, MA, ²School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, ³School of Mechanical Engineering, University of Louisville School of Medicine, Louisville, KY
*Purpose: The full potential of islet transplantation will only be realized by the development of tolerogenic strategies that obviate the need for maintenance immunosuppressants. We…
2020 American Transplant Congress
Significant Improvement in Short and Long-Term Kidney Transplant Survival Despite Stagnant Rates of Delayed Graft Function
J. Schold¹, S. Arrigain², E. Poggio³
¹Cleveland Clinic Foundation, Cleveland, OH, ²Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, OH, ³Nephrology, Cleveland Clinic Foundation, Cleveland, OH
*Purpose: Delayed Graft Function (DGF) is routinely characterized as attributing to significant morbidity and mortality among kidney transplant recipients. While there are diverse potential mechanisms…
2020 American Transplant Congress
Lymph Node Stromal Laminin Alpha5 Regulates Antigen Specific T Cell Adaptive Immunity
L. Li¹, M. Shirkey¹, W. Piao¹, Y. Xiong¹, V. Saxena¹, T. Zhang¹, C. Paluskievicz¹, J. Zhao², R. Abdi², J. S. Bromberg¹
¹UMB, Baltimore, MD, ²Harvard University, Boston, MA
*Purpose: Laminin α5 (Lama5) is associated with immunity and regulates T cell entry and responses within the lymph node (LN). We hypothesized that stromal Lama5…
2020 American Transplant Congress
Long-Term Allograft Survival via Donor MHC Chimerism Induced by Exosomes
B. Gonzalez Nolasco, X. Wang, M. Wang, A. Prunevieille, K. M. Lee, J. F. Markmann, G. Benichou
Surgery - Center for Transplantation Sciences, Massachusetts General Hospital & Harvard Medical School, Boston, MA
*Purpose: Allogeneic transplant tolerance has been achieved by inducing mixed hematopoietic chimerism via donor bone marrow transplantation. Tolerance mechanisms in this model involve the presentation…
2020 American Transplant Congress
Mobile Application for Communication Increases the Efficiency of Organ Procurement and Transplantation
E. Pahl
Health Informatics, University of Iowa, Iowa City, IA
*Purpose: Donor organ recovery is a complex process involving organ procurement organizations and multiple surgical teams from various transplant centers. According to the Organ Preservation…