2019 American Transplant Congress
Clinical Utility of a Pharmacogenomic Testing Tool among Kidney Transplant Recipients
Kidney/Pancreas Transplant Program, Intermountain Medical Center, Murray, UT
*Purpose: Therapeutic drug monitoring (TDM) for tacrolimus (Tac) is the cornerstone of clinical workflow in the transplant clinic. We report on the clinical implementation of,…2019 American Transplant Congress
Comprehensive and Combined Transcriptomic and Proteomic Analysis Reveals Key Factors Underlying Ischemia-Reperfusion Injury in Human Liver Transplantation
Organ Transplant Center, the First Affiliated Hospital of SYSU, Guangzhou, China
*Purpose: Ischemia-reperfusion injury (IRI) is a major challenge in liver resection and liver transplantation surgery. Hepatic IRI can seriously impair liver function and even cause…2019 American Transplant Congress
Epstein Barr Virus DNA Integration in B Cell Lymphomas of Post-Transplant Lymphoproliferative Disorder
Surgery, Division of Abdominal Transplant, Stanford University School of Medicine, Stanford, CA
*Purpose: Epstein Barr virus-positive (EBV+) B cell lymphomas can arise in immunosuppressed individuals, such as organ transplant recipients in the context of post-transplant lymphoproliferative disorder…2019 American Transplant Congress
Multi-Omics Approach to Accurately Assess Early Graft Injury in Liver Transplantation
*Purpose: We investigated global DNA methylation (DNAm) patterns during ischemia reperfusion (I/R) injury in liver transplant (LT) patients, and their role on regulating gene expression…2019 American Transplant Congress
Genomic Variations in Epstein Barr Virus are Associated with Post-Transplant Lymphoproliferative Disorder
Stanford Univ School of Med, Stanford, CA
*Purpose: Post-transplant lymphoproliferative disorder (PTLD) is a potentially fatal complication of organ transplantation characterized by abnormal proliferation of lymphoid cells in the setting of immunosuppression.…2019 American Transplant Congress
Apolipoprotein L1 Genotyping in Potential African American Living Kidney Donors
*Purpose: African Americans(AA) account for 13% of the US population, yet compose more than one third of dialysis patients. Inheriting two Apolipoprotein L1 gene (APOL1)…2019 American Transplant Congress
African American Living Kidney Donors’ Perceptions of APOL1 Genetic Testing and Its Impact on Ethnic Identity
1Northwestern University, Chicago, IL, 2Mayo Clinic, Rochester, MN
*Purpose: Apolipoprotein L1 (APOL1) risk variants may contribute to live kidney donors’ (“donors”) kidney failure post-donation. Because professional guidelines suggest informing potential donors with African…2019 American Transplant Congress
Not All Poor Metabolizers Are Clinically Equal: Evaluating Weight-Based Tacrolimus Outcomes in CYP3A Loss of Function Variants
Vidant Medical Center - Transplant Services, Greenville, NC
*Purpose: CYP3A polymorphisms are an important pharmacotherapeutic consideration due to the extensive CYP metabolism of tacrolimus (TAC) and variable expression among different races. The CPIC…2019 American Transplant Congress
Impact of Liver Recipient Genotype on Tacrolimus
*Purpose: In kidney transplant recipients, recipient genotype (CYP3A5 *3) has the greatest influence on tacrolimus pharmacokinetics (PK). However, in liver transplant recipient, donor liver and…2018 American Transplant Congress
Genomic Diversity of Epstein Barr Virus in Post-Transplant Lymphoproliferative Disorder
Purpose: In transplant recipients, Epstein-Barr Virus (EBV) is associated with the development of B cell lymphomas in post-transplant lymphoproliferative disorder (PTLD). We utilized next-generation sequencing…
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