ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Genomics"

  • 2022 American Transplant Congress

    De Novo Fibrinogen Alpha Chain Amyloidosis in Kidney Allograft

    T. Khaja1, L. Truong2, G. Nassar1

    1Nephrology, Houston Methodist Hospital, Houston, TX, 2Pathology, Houston Methodist Hospital, Houston, TX

    *Purpose: Amyloidosis is a disorder characterized by tissue deposition of misfolded proteins that can lead to organ damage such as renal failure. There are multiple…
  • 2022 American Transplant Congress

    Risk of Tumor Recurrence, Functional Decline, and Metastatic Disease of Renal Transplant in Recipients with Hereditary Kidney Cancer: A Case Series

    M. Antony, A. Chaurasia, N. Gopal, Z. Kozel, M. Linehan, M. Ball

    Urologic Oncology Branch, National Cancer Institute, Bethesda, MD

    *Purpose: Von Hippel-Lindau disease is a hereditary cancer syndrome characterized by bilateral, multifocal renal tumors and cysts. Advancements in nephron-sparing surgeries have improved functional and…
  • 2022 American Transplant Congress

    Single Cell RNAseq Analysis of Liver Transplant Rejection Reveals Highly Restricted TCR Clonal Expansion of Tissue-Resident Memory CD8+ T Cells That Persist Despite Corticosteroids and ATG Therapy

    A. L. Peters1, G. Begum1, K. Roskin2, E. Woodle3, D. Hildeman4

    1Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Department of Bioinformatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 3Department of Surgery, University of Cincinnati, Cincinnati, OH, 4Department of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

    *Purpose: Conventional therapy for liver transplant rejection (corticosteroids and ATG) has remained unchanged for six decades, and is not infrequently met with treatment failure. Here,…
  • 2022 American Transplant Congress

    Development of an M2 Macrophage Signature in Spontaneously Accepted Kidney Allografts

    M. T. Guinn1, E. S. Szuter1, T. Yokose1, J. Ge2, B. Kwon1, I. Rosales3, P. S. Russell1, A. G. Cuenca2, J. C. Madsen4, R. B. Colvin3, A. Alessandrini1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Department of Surgery, Boston Children's Hospital, Boston, MA, 3Department of Pathology, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 4Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA

    *Purpose: Kidney allografts transplanted across certain mouse strain combinations (e.g. DBA/2 to B6) are spontaneously accepted. We have recently shown that novel regulatory Tertiary Lymphoid…
  • 2022 American Transplant Congress

    Living Related Kidney Donation for Alport Syndrome Spectrum: Long-Term Outcomes

    Y. Caliskan1, A. B. Dirim2, S. Safak2, B. Yelken3, A. Velioglu4, A. Yildiz5, O. A. Oto2, N. Guller2, H. Yazici2, A. Ersoy5, A. Turkmen3, K. L. Lentine1

    1Saint Louis University, Saint Louis, MO, 2Istanbul University, Istanbul, Turkey, 3Koc University Hospital, Istanbul, Turkey, 4Marmara University, Istanbul, Turkey, 5Uludag University, Bursa, Turkey

    *Purpose: Data to guide the evaluation of living related donor (LRD) candidates for kidney transplant recipients with Alport syndrome (AS) spectrum are limited. We examined…
  • 2022 American Transplant Congress

    Does Gene Mutation Carrier Status Contribute to Risk of Kidney Failure?

    S. A. Muhsin, R. Saranu, B. Schreiber, E. Milford, M. Y. Yeung, A. Chandraker

    Renal Division, Brigham and Women's Hospital, Boston, MA

    *Purpose: To examine the frequency of genetic abnormalities in end stage kidney disease patients either on the kidney transplant waitlist or have already been transplanted.*Methods:…
  • 2022 American Transplant Congress

    Defects in Kim-1 Do Not Result In Delayed Graft Function After Kidney Transplantation

    R. S. Suri1, J. Lee2, M. Ban3, B. Shrum2, O. Z. Ismail4, S. Leckie5, A. McIntyre3, Q. Xu6, S. H. Lee2, S. de Chickera2, R. A. Hegele2, L. Gunaratnam2

    1Research Institute of the McGill University Health Center, Montreal, QC, Canada, 2Schulich School of Medicine and Dentistry, Western University, Lodnon, ON, Canada, 3Robarts Research Institute, Lodnon, ON, Canada, 4University of Alberta, Edmonton, AB, Canada, 5London Health Sciences Centre, Lodnon, ON, Canada, 6University of Pittsburg Medical Center, Pittsburg, PA

    *Purpose: Tissue repair is critical to restore organ function after ischemia-reperfusion injury (IRI) during transplantation. During renal injury, upregulation of kidney injury molecule-1 (KIM-1) transforms…
  • 2022 American Transplant Congress

    Identification of Akkermansia Muciniphila and Bacteroides Thetaiotaomicron Associated with the Alleviation of Peritransplant Liver Damage in Mouse Recipients

    K. Dery1, H. Kojima2, H. Hirao2, K. Kadono3, T. Dong2, J. Kupiec-Weglinski4

    1Surgery, UCLA, Los Angeles, CA, 2UCLA, Los Angeles, CA, 3Liver Transplant Surgery, UCLA, Los Angeles, CA, 4UCLA Medical Center, Los Angeles, CA

    *Purpose: Although recent evidence shows that modifications of gut microbiota by antibiotics (Abx) influences liver allograft function, its compositional role in orthotopic liver transplantation (OLT)…
  • 2022 American Transplant Congress

    Autencoder, a Novel Computational Tool to Score T Cell Clones Demonstrates Biopsy T Cell Clones Are Not Represented in the Peripheral Blood

    N. Borcherding, A. Leckie-Harre, H. Wu, B. D. Humphreys, A. F. Malone

    Washington University, St Louis, MO

    *Purpose: Antibody-mediated rejection (AMR) remains one of the major causes of allograft failure and our understanding of this disease process is poor. The generation and…
  • 2022 American Transplant Congress

    Single Cell RNAseq Analysis of Human Renal Allograft Rejection Demonstrates Distinct Transcriptomic Profiles That Vary Based on the Type of Maintenance Immunosuppression

    T. Shi1, A. Burg1, K. Roskin2, J. Rush3, B. Haraldsson3, A. Shields4, R. Alloway4, E. Woodle5, D. Hildeman1

    1Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 3Novartis Pharmaceuticals AG, Basel, Switzerland, 4Internal Medicine, University of Cincinnati, Cincinnati, OH, 5Surgery, University of Cincinnati, Cincinnati, OH

    *Purpose: Rejection therapy has remained unchanged for 60 years and is associated with significant failure and infection rates. Development of new anti-rejection therapies requires mechanistic…
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