Articles tagged "Genomics"

2022 American Transplant Congress
De Novo Fibrinogen Alpha Chain Amyloidosis in Kidney Allograft
T. Khaja¹, L. Truong², G. Nassar¹
¹Nephrology, Houston Methodist Hospital, Houston, TX, ²Pathology, Houston Methodist Hospital, Houston, TX
*Purpose: Amyloidosis is a disorder characterized by tissue deposition of misfolded proteins that can lead to organ damage such as renal failure. There are multiple…
2022 American Transplant Congress
Risk of Tumor Recurrence, Functional Decline, and Metastatic Disease of Renal Transplant in Recipients with Hereditary Kidney Cancer: A Case Series
M. Antony, A. Chaurasia, N. Gopal, Z. Kozel, M. Linehan, M. Ball
Urologic Oncology Branch, National Cancer Institute, Bethesda, MD
*Purpose: Von Hippel-Lindau disease is a hereditary cancer syndrome characterized by bilateral, multifocal renal tumors and cysts. Advancements in nephron-sparing surgeries have improved functional and…
2022 American Transplant Congress
Single Cell RNAseq Analysis of Liver Transplant Rejection Reveals Highly Restricted TCR Clonal Expansion of Tissue-Resident Memory CD8⁺ T Cells That Persist Despite Corticosteroids and ATG Therapy
A. L. Peters¹, G. Begum¹, K. Roskin², E. Woodle³, D. Hildeman⁴
¹Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Department of Bioinformatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Department of Surgery, University of Cincinnati, Cincinnati, OH, ⁴Department of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
*Purpose: Conventional therapy for liver transplant rejection (corticosteroids and ATG) has remained unchanged for six decades, and is not infrequently met with treatment failure. Here,…
2022 American Transplant Congress
Development of an M2 Macrophage Signature in Spontaneously Accepted Kidney Allografts
M. T. Guinn¹, E. S. Szuter¹, T. Yokose¹, J. Ge², B. Kwon¹, I. Rosales³, P. S. Russell¹, A. G. Cuenca², J. C. Madsen⁴, R. B. Colvin³, A. Alessandrini¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Surgery, Boston Children's Hospital, Boston, MA, ³Department of Pathology, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ⁴Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
*Purpose: Kidney allografts transplanted across certain mouse strain combinations (e.g. DBA/2 to B6) are spontaneously accepted. We have recently shown that novel regulatory Tertiary Lymphoid…
2022 American Transplant Congress
Living Related Kidney Donation for Alport Syndrome Spectrum: Long-Term Outcomes
Y. Caliskan¹, A. B. Dirim², S. Safak², B. Yelken³, A. Velioglu⁴, A. Yildiz⁵, O. A. Oto², N. Guller², H. Yazici², A. Ersoy⁵, A. Turkmen³, K. L. Lentine¹
¹Saint Louis University, Saint Louis, MO, ²Istanbul University, Istanbul, Turkey, ³Koc University Hospital, Istanbul, Turkey, ⁴Marmara University, Istanbul, Turkey, ⁵Uludag University, Bursa, Turkey
*Purpose: Data to guide the evaluation of living related donor (LRD) candidates for kidney transplant recipients with Alport syndrome (AS) spectrum are limited. We examined…
2022 American Transplant Congress
Does Gene Mutation Carrier Status Contribute to Risk of Kidney Failure?
S. A. Muhsin, R. Saranu, B. Schreiber, E. Milford, M. Y. Yeung, A. Chandraker
Renal Division, Brigham and Women's Hospital, Boston, MA
*Purpose: To examine the frequency of genetic abnormalities in end stage kidney disease patients either on the kidney transplant waitlist or have already been transplanted.*Methods:…
2022 American Transplant Congress
Defects in Kim-1 Do Not Result In Delayed Graft Function After Kidney Transplantation
R. S. Suri¹, J. Lee², M. Ban³, B. Shrum², O. Z. Ismail⁴, S. Leckie⁵, A. McIntyre³, Q. Xu⁶, S. H. Lee², S. de Chickera², R. A. Hegele², L. Gunaratnam²
¹Research Institute of the McGill University Health Center, Montreal, QC, Canada, ²Schulich School of Medicine and Dentistry, Western University, Lodnon, ON, Canada, ³Robarts Research Institute, Lodnon, ON, Canada, ⁴University of Alberta, Edmonton, AB, Canada, ⁵London Health Sciences Centre, Lodnon, ON, Canada, ⁶University of Pittsburg Medical Center, Pittsburg, PA
*Purpose: Tissue repair is critical to restore organ function after ischemia-reperfusion injury (IRI) during transplantation. During renal injury, upregulation of kidney injury molecule-1 (KIM-1) transforms…
2022 American Transplant Congress
Identification of Akkermansia Muciniphila and Bacteroides Thetaiotaomicron Associated with the Alleviation of Peritransplant Liver Damage in Mouse Recipients
K. Dery¹, H. Kojima², H. Hirao², K. Kadono³, T. Dong², J. Kupiec-Weglinski⁴
¹Surgery, UCLA, Los Angeles, CA, ²UCLA, Los Angeles, CA, ³Liver Transplant Surgery, UCLA, Los Angeles, CA, ⁴UCLA Medical Center, Los Angeles, CA
*Purpose: Although recent evidence shows that modifications of gut microbiota by antibiotics (Abx) influences liver allograft function, its compositional role in orthotopic liver transplantation (OLT)…
2022 American Transplant Congress
Autencoder, a Novel Computational Tool to Score T Cell Clones Demonstrates Biopsy T Cell Clones Are Not Represented in the Peripheral Blood
N. Borcherding, A. Leckie-Harre, H. Wu, B. D. Humphreys, A. F. Malone
Washington University, St Louis, MO
*Purpose: Antibody-mediated rejection (AMR) remains one of the major causes of allograft failure and our understanding of this disease process is poor. The generation and…
2022 American Transplant Congress
Single Cell RNAseq Analysis of Human Renal Allograft Rejection Demonstrates Distinct Transcriptomic Profiles That Vary Based on the Type of Maintenance Immunosuppression
T. Shi¹, A. Burg¹, K. Roskin², J. Rush³, B. Haraldsson³, A. Shields⁴, R. Alloway⁴, E. Woodle⁵, D. Hildeman¹
¹Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Novartis Pharmaceuticals AG, Basel, Switzerland, ⁴Internal Medicine, University of Cincinnati, Cincinnati, OH, ⁵Surgery, University of Cincinnati, Cincinnati, OH
*Purpose: Rejection therapy has remained unchanged for 60 years and is associated with significant failure and infection rates. Development of new anti-rejection therapies requires mechanistic…

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