Articles tagged "Genomics"

2022 American Transplant Congress
Evaluation of Compliance and Efficacy with Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Tacrolimus in Kidney Transplant Recipients
M. Nikirk¹, J. Chen¹, E. Tillman²
¹Indiana University Health, Indianapolis, IN, ²Indiana University School of Medicine, Indianapolis, IN
*Purpose: The purpose of this study is to evaluate compliance and efficacy of The Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 genotype guided tacrolimus…
2022 American Transplant Congress
The Role of the Gut Microbiota in Pain Interference Before and After Kidney Transplantation: A Pilot Study
M. B. Lockwood¹, H. DeVon², M. Maienschein-Cline¹, G. Chlipala¹, M. Samra³, A. Lichvar⁴, S. Green⁵
¹University of Illinois at Chicago, Chicago, IL, ²UCLA, Los Angeles, CA, ³Loyola University Medical Center, Chicago, IL, ⁴UCSD, San Diego, CA, ⁵Rush University, Chicago, IL
*Purpose: To characterize relationships between differential relative abundances of taxonomy (genus level) of the gut microbiome and pain interference before and after living donor kidney…
2022 American Transplant Congress
Pharmacogenomic Dosing in Kidney Transplant Patients Converted from Tacrolimus Immediate Release to Tacrolimus Extended Release (Envarsus XR®)
K. D. Belfield¹, K. J. Armstrong², D. Malhotra³, G. F. Girone¹
¹Department of Pharmacy, Yale New Haven Hospital, New Haven, CT, ²Department of Pharmacy, Hospital of Central Connecticut, New Britain, CT, ³Section of Nephrology, Yale School of Medicine, New Haven, CT
*Purpose: When converting from tacrolimus (tac) immediate release (tacIR) to tac extended release (Envarsus XR; tacXR), the package insert (PI) recommends 80% of the tacIR…
2022 American Transplant Congress
Dd-cfdna Correlates With Acute Rejection In The Setting Of Bk Viremia After Kidney Transplantation
N. M. Ali¹, J. Miles², V. Tatapudi¹, R. Chand¹, R. Montgomery¹
¹NYU Langone Transplant Institute, New York, NY, ²CareDx, Brooklyn, NY
*Purpose: BK virus reactivation is common among kidney transplant recipients (KTRs) and is a risk factor for allograft loss. Currently, there is no clearly established…
2022 American Transplant Congress
The Molecular Landscape of Bk Polyomavirus Infection in Kidney Transplant Recipients at Single Cell Resolution
P. J. McCown, E. Farkash, F. Alakwaa, F. Eichinger, R. Menon, E. Otto, C. C. Berthier, K. J. Woodside, S. Norman, M. Kretzler, A. Naik
University of Michigan, Ann Arbor, MI
*Purpose: BK polyomavirus has devastating consequences in patients with kidney transplants. While in vitro studies in primary epithelial cell lines, and bulk transcriptomic studies in…
2022 American Transplant Congress
Single Nuclei RNA-Sequencing Identifies Distinct Cell Profile in Kidney Allografts with Recurrent Focal Segmental Glomerular Sclerosis (FSGS)
L. Gallon¹, E. Bardhi², J. McDaniels², A. Shetty², P. Hallack¹, C. Kuscu³, C. Kuscu³, T. Rousselle², J. Eason³, D. Maluf², V. Mas²
¹NWU, Chicago, IL, ²University of Maryland, Baltimore, MD, ³UTHSC, Memphis, TN
*Purpose: Strong evidence suggests that primary FSGS is due to a plasma factor that results in general podocyte dysfunction and risk of recurrence after kidney…
2022 American Transplant Congress
Combined Genome Wide and Single Nuclei Transcriptomics in Posttransplant Acute Kidney Injury Identifies Early Proinflammatory/Profibrogenic Cell Origin
J. McDaniels¹, T. Rousselle¹, E. Bardhi¹, A. Shetty¹, E. Akalin², D. Maluf¹, V. Mas¹
¹University of Maryland, Baltimore, MD, ²Albert Einstein College of Medicine, Montefiore Medical Ctr, Bronx, NY
*Purpose: Kidney transplants offer a unique opportunity to evaluate molecular pathways involved in development and response to acute kidney injury (AKI). This prospective study of…
2022 American Transplant Congress
Possible Recurrence Must Not Limit Kidney Transplantations for Patients with Focal Segmental Glomerulosclerosis
A. Angeletti, M. Gentile, G. Ghiggeri, M. Bruschi, F. Lugani, G. Caridi
Istituto Giannina Gaslini, Genova, Italy
*Purpose: Non-genetic forms of Focal Segmental Glomerulosclerosis (FSGS) are at high risk of recurrence after kidney transplant (KT) (55%), when compared to inherited forms (0-4%)…
2022 American Transplant Congress
Multiomic Analyses Of Two Pig Kidney To Human Xenotransplants
B. Keating¹, B. Piening², M. Mangiola³, J. Stern⁴, W. Zhang⁵, A. Griesemer⁶, B. Lonze⁷, M. Snyder⁸, J. Boeke⁵, R. Montgomery⁷
¹University of Pennsylvania, Philadelphia, PA, ²Providence Cancer Center, Portland, OR, ³New York University Langone Medical Center, New York, NY, ⁴Department of Surgery, NYU Langone, New York, NY, ⁵Institute of Systems Genetics, NYU Langone, New York, NY, ⁶Surgery, NYU Langone, New York, NY, ⁷NYU Langone Transplant Institute, New York, NY, ⁸Genetics, Stanford, Palo Alto, CA
*Purpose: Organ shortage remains a major limitation within transplantation, with waiting lists greatly outpacing the number of donors available. Pig organs offer significant advantages for…
2022 American Transplant Congress
Blood Transcriptomes of Covid-19 Infected Kidney Recipients Demonstrate Frequent and Persistent Sars-cov-2 Virome Gene Expression
Z. Sun¹, M. M. Rana², A. C. Reghuvaran³, Y. A. Azzi⁴, G. Carrara⁵, S. Hartzell⁶, S. Kulkarni³, W. Zhang⁶, K. Banu³, P. Heeger⁶, E. Akalin⁴, P. Cravedi⁶, Z. Zhang⁷, M. C. Menon³
¹Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, ²Infectious Disease Director, Icahn School of Medicine at Mount Sinai, New York, NY, ³Nephrology, Yale University, New Haven, CT, ⁴Nephrology, Montefiore Medical Center, New York, NY, ⁵Clinical Research Coordinator, Icahn School of Medicine at Mount Sinai, New York, NY, ⁶Icahn School of Medicine at Mount Sinai, New York, NY, ⁷Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Kidney transplant recipients (KTRs) have poor outcomes vs non-KTRs with acute COVID-19. To provide insight into management of immunosuppression during acute COVID-19, we studied…

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