2020 American Transplant Congress
Prevalence of Risk Factors for NAFLD among Living Liver Donors
*Purpose: The development of non-alcoholic fatty liver (NAFLD) disease has been strongly associated with the presence of polymorphisms in PNPLA3 rs738409. When compared with wild…2020 American Transplant Congress
Single Cell Profiling of PBMC Identifies Immune Populations Associated with High Risk of Early Acute Rejection
Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Our previous transcriptomic analysis of pre-transplant peripheral blood revealed a 23-gene set predictive of early acute rejection (EAR) post kidney transplant (JCI Insight, 2019).…2020 American Transplant Congress
Introduction of Preemptive Pharmacogenomic Testing in Kidney Transplant Recipients: Early Evaluation of the Clinical Impact of Genomic Guided Tacrolimus Dosing
*Purpose: Tacrolimus is widely accepted as the mainstay of immunosuppression in solid organ transplant. Inherited differences in CYP3A activity are known to contribute to dosing…2020 American Transplant Congress
Single-Cell RNA Sequencing to Assess the Effect of IL-6 Receptor Blockade in Kidney Transplantation
University of California San Francisco, San Francisco, CA
*Purpose: Prospective randomized study of IL-6R blockade with Tocilizumab for treatment of subclinical inflammation (SCI) in renal transplantation, reveals unique profiles of resting and stimulated…2020 American Transplant Congress
Elucidating the Genetic Background of End Stage Renal Disease of Unknown Aetiology in Patients Listed for Kidney Transplantation
*Purpose: The prevalence of end stage renal disease (ESRD) of unknown aetiology in adult patients accounts for almost 20% of all dialysis patients in Europe.…2020 American Transplant Congress
Identification of Molecular Markers for Liver Cirrhosis (NASH) by Single-Nucleus RNA Sequencing
*Purpose: Non-alcoholic fatty liver disease (NAFLD) is a progressive disease and it constitutes a significant portion of the chronic liver diseases that affected more than…2020 American Transplant Congress
Kidney Transplantation in Inherited Kidney Diseases
*Purpose: We aimed to evaluate the kidney transplant (KTx) recipients with inherited kidney diseases and investigate the causal genetic variants in recipients with undetermined etiology.*Methods:…2020 American Transplant Congress
Genetic Testing of Living Related Donors for Inherited Renal Disease Improves Evaluation and Promotes Informed Choice of At-Risk Living Donors
1Internal Medicine, University of Iowa, Iowa City, IA, 2Surgery, University of Iowa, Iowa City, IA
*Purpose: Living kidney donors (LKDs) with a family history of kidney disease are at higher risk of end-stage renal disease (ESRD) compared to LKDs without…2020 American Transplant Congress
Transcriptomic Profiling of Paired Serum and Biopsy Samples from FSGS Patients
*Purpose: Pathogenesis and molecular footprints of focal segmental glomerulosclerosis (FSGS) after kidney transplantation whether it is primary or secondary is unknown. Herein, we studied a…2020 American Transplant Congress
Physician Survey on Using APOL1 Genetic Testing in Live Kidney Donor Selection
*Purpose: Live kidney donors of recent African ancestry are at an increased risk of developing end stage kidney disease than matched healthy non-donors. A recent…
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