Articles tagged "Gene polymorphism"

2019 American Transplant Congress
Effects of IVIG Therapy and FcγR Polymorphisms on BK Virus Nephropathy in Kidney Transplant Recipients
D. I. Min¹, Y. Chang², T. Shah³
¹Western Univ of Health Sciences, Los Angeles, CA, ²Mendez National Institute of Transplantation Foundation, Los Angeles, CA, ³St. Vincent Medical Center, Los Angeles, CA
*Purpose: BK Virus Nephropathy (BKVN) is a major complication in kidney transplant patients. Although standard treatment for BKVN is immunosuppression reduction and/or using leflunomide, studies…
2019 American Transplant Congress
What’s in a High Dose? An Analysis of Tacrolimus Pharmacokinetic Parameters in Rapid Metabolizers
P. West-Thielke¹, A. Maldonado², S. J. Patel³, D. R. Stevens³, U. Meier-Kriesche³, D. Brennan⁴
¹University of Illinois, Chicago, Chicago, IL, ²Vidant Medical Center, Greenville, NC, ³Veloxis Pharmaceuticals Inc., Cary, NC, ⁴Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: CYP3A5*1 expressers exhibit differences in immediate-release tacrolimus (IR-Tac) PK and require higher doses of IR-Tac to maintain therapeutic trough concentrations. LCP-Tacrolimus (LCPT) demonstrates a…
2019 American Transplant Congress
Tacrolimus Pharmacokinetics in Young, Middle Age and Older Renal Transplant Recipients- Impact of CYP3A5*3*6*7 Metabolic Composite
K. Tornatore¹, K. Attwood², D. Brazeau³, R. Venuto⁴
¹University at Buffalo; School of Pharmacy, Buffalo, NY, ²Biostatistics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, ³Marshall University; School of Medicine, Huntington, WV, ⁴University at Buffalo; School of Medicine, Buffalo, NY
*Purpose: In spite of increased renal transplantation in patients over 60 years and the need for age-adjusted tacrolimus maintenance immunosuppression, limited pharmacokinetic comparisons between young,…
2019 American Transplant Congress
Polymorphisms in Mycophenolate Mofetil Glucuronidation Gene Are Associated with Leukopenia and Decreased CLAD-Free Survival
A. Barnes, D. R. Calabrese, E. Henricksen, R. Florez, K. Dewey, P. Wang, J. Teraoka, K. Lien, S. Hays, J. P. Singer, J. Golden, J. Kukreja, J. R. Greenland
UCSF Medical Center, San Francisco, CA
*Purpose: Lung transplant recipients vary in their tolerance of the immunosuppressant mycophenolate mofetil (MMF). Single nucleotide polymorphisms (SNPs) in UDP-glucuronosyltransferase 2B7 (UGT2B7) increase conversion of…
2019 American Transplant Congress
Involvement of Genetic Variation and Related Gene Expression Changes on Acute Rejection in Renal Transplant Recipients
H. Hwang¹, J. Seo¹, J. Kim¹, Y. Kim¹, J. Moon¹, K. Jeong¹, C. Kim², J. Park³, B. Chung⁴, Y. Kim⁵, S. Lee¹
¹Division of Nephrology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea, Republic of, ²Division of Nephrology, Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea, Republic of, ³Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of, ⁴Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea, Seoul, Korea, Republic of, ⁵Division of Nephrology, Department of Internal Medicine, College of Medicine, Inje University, Pusan, Korea, Republic of
*Purpose: Acute rejection (AR) is one of the major risk factors for renal allograft loss. The effect of genetic factors on the transplant outcomes has…
2019 American Transplant Congress
Natural Killer Cells Express Significantly More CD16 during Chronic Active Antibody Mediated Rejection Which is Not Caused by a Single Nucleotide Polymorphism within the CD16 Gene
K. Sablik, N. Litjens, A. Peeters, M. Clahsen-van Groningen, M. Klepper, M. Betjes
Erasmus MC, Rotterdam, Netherlands
*Purpose: Chronic-active antibody mediated rejection (c-aABMR) is the leading cause of long-term renal allograft loss. Fc-receptor CD16 bearing natural killer (NK) cells may be involved…
2019 American Transplant Congress
CYP3A5 Genotype Had No Influence on Renal Function after Renal Transplantation
J. E. Kimpton, A. J. Hughes, I. MacPhee
Renal Medicine and Transplantation, St George’s University Hospitals NHS Foundation Trust, London, United Kingdom
*Purpose: Tacrolimus metabolism rate has been reported to be associated with renal function after renal transplantation (Thölking et al., 2014); this study aimed to determine…
2019 American Transplant Congress
Phylogenetic Analysis of the Epstein Barr Virus Nuclear Antigen-1 and Associated Correlates among Canadian Transplant Patients
M. Abdulnoor¹, S. Isabel¹, T. Paton¹, N. Khodai-Booran¹, T. Schechter¹, P. Birk², T. Blydt-Hansen³, B. Foster⁴, S. Mital¹, V. Phan⁵, S. Urschel⁶, G. Casallo¹, T. Papaz¹, L. Hamiwka⁷, S. Min¹, U. Allen¹
¹University of Toronto, Toronto, ON, Canada, ²University of Manitoba, Winnipeg, MB, Canada, ³University of British Columbia, Vancouver, BC, Canada, ⁴McGill University, Montreal, QC, Canada, ⁵University of Montreal, Montreal, QC, Canada, ⁶University of Alberta, Edmonton, AB, Canada, ⁷University of Calgary, Calgary, AB, Canada
*Purpose: The effect of the genetic diversity of the Epstein-Barr virus (EBV) on clinical outcomes in the transplant setting is important to study. We examined…
2019 American Transplant Congress
Studying the Association of Melanocortin Receptor-4 Gene Polymorphism and Renal Transplant Rejection
F. Yilmaz¹, R. Abdi¹, B. J. Keating², V. R. Mas³
¹Renal Division, Transplantation Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ²Surgery, Perelman School of Medicine University of Pennsylvania, Philadelphia, PA, ³Director Transplant Research Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN
*Purpose: Accumulating experimental data highlight the importance of targeting the innate immune response to improve transplant outcomes. Inflammation is an unavoidable consequence of transplantation. The…
2018 American Transplant Congress
Donor TM6SF2 rs58542926 Genotype is a Risk Factor for Liver Graft Steatosis
I. Mikova,¹ M. Neroldova,² J. Hubacek,² D. Dlouha,² L. Kolesar,³ M. Jirsa,² E. Honsova,⁴ E. Sticova,⁴ V. Lanska,⁵ J. Spicak,¹ P. Trunecka.¹
¹Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; ²Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; ³Department of Clinical and Transplant Immunology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; ⁴Department of Clinical and Transplant Pathology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; ⁵Medical Statistics Unit, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Background & Aims: The rs58542926 c.449C>T (p.E167K) polymorphism in TM6SF2 (transmembrane 6 superfamily member 2) is one of genetic factors predisposing to nonalcoholic fatty liver…