Articles tagged "Gene polymorphism"

2019 American Transplant Congress
CYP3A5 Genotype Had No Influence on Renal Function after Renal Transplantation
J. E. Kimpton, A. J. Hughes, I. MacPhee
Renal Medicine and Transplantation, St George’s University Hospitals NHS Foundation Trust, London, United Kingdom
*Purpose: Tacrolimus metabolism rate has been reported to be associated with renal function after renal transplantation (Thölking et al., 2014); this study aimed to determine…
2019 American Transplant Congress
Phylogenetic Analysis of the Epstein Barr Virus Nuclear Antigen-1 and Associated Correlates among Canadian Transplant Patients
M. Abdulnoor¹, S. Isabel¹, T. Paton¹, N. Khodai-Booran¹, T. Schechter¹, P. Birk², T. Blydt-Hansen³, B. Foster⁴, S. Mital¹, V. Phan⁵, S. Urschel⁶, G. Casallo¹, T. Papaz¹, L. Hamiwka⁷, S. Min¹, U. Allen¹
¹University of Toronto, Toronto, ON, Canada, ²University of Manitoba, Winnipeg, MB, Canada, ³University of British Columbia, Vancouver, BC, Canada, ⁴McGill University, Montreal, QC, Canada, ⁵University of Montreal, Montreal, QC, Canada, ⁶University of Alberta, Edmonton, AB, Canada, ⁷University of Calgary, Calgary, AB, Canada
*Purpose: The effect of the genetic diversity of the Epstein-Barr virus (EBV) on clinical outcomes in the transplant setting is important to study. We examined…
2019 American Transplant Congress
Studying the Association of Melanocortin Receptor-4 Gene Polymorphism and Renal Transplant Rejection
F. Yilmaz¹, R. Abdi¹, B. J. Keating², V. R. Mas³
¹Renal Division, Transplantation Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ²Surgery, Perelman School of Medicine University of Pennsylvania, Philadelphia, PA, ³Director Transplant Research Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN
*Purpose: Accumulating experimental data highlight the importance of targeting the innate immune response to improve transplant outcomes. Inflammation is an unavoidable consequence of transplantation. The…
2019 American Transplant Congress
CNV Screening For End-stage Renal Disease
C. E. Fishman, B. Chang, A. Shaked, B. J. Keating
Surgery, University of Pennsylvania, Philadelphia, PA
*Purpose: The prevalence of ESRD in the United States was 2,160.7 cases per one million individuals in 2016, and a primary cause of ESRD was…
2019 American Transplant Congress
Relationship between HLA-DPB1 Gene Expression in Pre-Implantation Kidney Biopsies, Rs9277534 Polymorphism, and Late Graft Function
K. L. Mine¹, T. B. Mourão¹, C. Felipe², G. F. Rampim¹, J. O. Medina-Pestana², H. Tedesco-Silva², M. Gerbase-DeLima¹
¹Immunogenetics Institute, Associação Fundo de Incentivo a Pesquisa - AFIP, Sao Paulo, SP, Brazil, ²Hospital do Rim, Sao Paulo, SP, Brazil
*Purpose: A previous gene expression microarray study in pre-implantation biopsies (PIB) from kidneys of adult deceased donors (D) showed association between high class II HLA…
2019 American Transplant Congress
Combined Pre-Transplant Anti-Donor T-Cell Sensitization with Single Nucleotid Polimorphisms (SNPs) for CYP3A4 Tacrolimus Metabolism Identifies Kidney Transplant Patients at High Risk of Allograft Rejection
E. Crespo¹, A. Vidal¹, A. Sefrin², P. Fontova¹, M. Stein², H. Volk², J. Grinyó³, P. Reinke², N. Lloberas¹, O. Bestard³
¹Experimental Nephrology Laboratory, IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain, ²Nephrology, Charité Campus Virchow-Klinikum, Berlin, Germany, ³Kidney Transplant Unit, Bellvitge University Hospital- IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain
*Purpose: Preformed donor-specific (d-sp) T-cell alloimmunity has been associated to high risk of acute rejection (BPAR). Since the individual susceptibility related to specific single nucleotide…
2019 American Transplant Congress
Impact of Prolonged Venous Thromboembolism Prophylaxis on 30-Day Hemostatic Outcomes Following Kidney Transplantation in Patients with Hypercoagulable Risk Factors
V. Behbahani, A. Santeusanio, S. Ames, R. Shapiro
Mount Sinai Hospital, New York, NY
*Purpose: A number of hypercoagulable states have been identified through laboratory testing that place patients at greater risk for thrombosis; however, the appropriate management of…
2019 American Transplant Congress
Evaluation Of Complement-related Factors In Tma Post-kidney Transplantation: A Retrospective Multicenter Study
N. Fujiyama¹, M. Tasaki², H. Harada³, K. Tsutahara⁴, A. Matsumoto⁵, Y. Hara⁶, M. Okumi⁷, K. Saito², Y. Watarai⁸, N. Inoue⁹, N. Wakamiya⁹, S. Satoh¹
¹Center for Kidney Disease and Transplantaion, Akita University Hospital, Akita, Japan, ²Department of Urology, Niigata University, Niigata, Japan, ³Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Japan, ⁴Department of Urology, Osaka General Medical Center, Osaka, Japan, ⁵Department of Urology, The University of Tokyo, Tokyo, Japan, ⁶Department of Nephrolog, Shinsyu University Hospital, Shinsyu, Japan, ⁷Department of Urology, Tokyo Women’s Medical University, Tokyo, Japan, ⁸Department of Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan, ⁹The Japanese Association for Complement Research, Osaka, Japan
*Purpose: Post-kidney transplant thrombotic microangiopathy (KT-TMA) is a poor prognostic complication that causes a high rate of graft loss. In this study, we investigated KT-TMA-associated…
2019 American Transplant Congress
Effects of IVIG Therapy and FcγR Polymorphisms on BK Virus Nephropathy in Kidney Transplant Recipients
D. I. Min¹, Y. Chang², T. Shah³
¹Western Univ of Health Sciences, Los Angeles, CA, ²Mendez National Institute of Transplantation Foundation, Los Angeles, CA, ³St. Vincent Medical Center, Los Angeles, CA
*Purpose: BK Virus Nephropathy (BKVN) is a major complication in kidney transplant patients. Although standard treatment for BKVN is immunosuppression reduction and/or using leflunomide, studies…
2018 American Transplant Congress
Identification of Human SIRPa Diversity That Could Regulate Innate Allorecognition
A. Friday,¹ H. Dai,¹ A. Williams,¹ M. Oberbarnscheidt,¹ J. Danska,² F. Lakkis.¹
¹Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA; ²Immunology and Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Innate allorecognition is a process by which myeloid cells, such as monocytes, distinguish syngeneic from allogeneic cells. Monocytes that recognize donor cells as non-self differentiate…