ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Gene polymorphism"

  • 2019 American Transplant Congress

    Relationship between HLA-DPB1 Gene Expression in Pre-Implantation Kidney Biopsies, Rs9277534 Polymorphism, and Late Graft Function

    K. L. Mine1, T. B. Mourão1, C. Felipe2, G. F. Rampim1, J. O. Medina-Pestana2, H. Tedesco-Silva2, M. Gerbase-DeLima1

    1Immunogenetics Institute, Associação Fundo de Incentivo a Pesquisa - AFIP, Sao Paulo, SP, Brazil, 2Hospital do Rim, Sao Paulo, SP, Brazil

    *Purpose: A previous gene expression microarray study in pre-implantation biopsies (PIB) from kidneys of adult deceased donors (D) showed association between high class II HLA…
  • 2019 American Transplant Congress

    Combined Pre-Transplant Anti-Donor T-Cell Sensitization with Single Nucleotid Polimorphisms (SNPs) for CYP3A4 Tacrolimus Metabolism Identifies Kidney Transplant Patients at High Risk of Allograft Rejection

    E. Crespo1, A. Vidal1, A. Sefrin2, P. Fontova1, M. Stein2, H. Volk2, J. Grinyó3, P. Reinke2, N. Lloberas1, O. Bestard3

    1Experimental Nephrology Laboratory, IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain, 2Nephrology, Charité Campus Virchow-Klinikum, Berlin, Germany, 3Kidney Transplant Unit, Bellvitge University Hospital- IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain

    *Purpose: Preformed donor-specific (d-sp) T-cell alloimmunity has been associated to high risk of acute rejection (BPAR). Since the individual susceptibility related to specific single nucleotide…
  • 2019 American Transplant Congress

    Impact of Prolonged Venous Thromboembolism Prophylaxis on 30-Day Hemostatic Outcomes Following Kidney Transplantation in Patients with Hypercoagulable Risk Factors

    V. Behbahani, A. Santeusanio, S. Ames, R. Shapiro

    Mount Sinai Hospital, New York, NY

    *Purpose: A number of hypercoagulable states have been identified through laboratory testing that place patients at greater risk for thrombosis; however, the appropriate management of…
  • 2019 American Transplant Congress

    Evaluation Of Complement-related Factors In Tma Post-kidney Transplantation: A Retrospective Multicenter Study

    N. Fujiyama1, M. Tasaki2, H. Harada3, K. Tsutahara4, A. Matsumoto5, Y. Hara6, M. Okumi7, K. Saito2, Y. Watarai8, N. Inoue9, N. Wakamiya9, S. Satoh1

    1Center for Kidney Disease and Transplantaion, Akita University Hospital, Akita, Japan, 2Department of Urology, Niigata University, Niigata, Japan, 3Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Japan, 4Department of Urology, Osaka General Medical Center, Osaka, Japan, 5Department of Urology, The University of Tokyo, Tokyo, Japan, 6Department of Nephrolog, Shinsyu University Hospital, Shinsyu, Japan, 7Department of Urology, Tokyo Women’s Medical University, Tokyo, Japan, 8Department of Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan, 9The Japanese Association for Complement Research, Osaka, Japan

    *Purpose: Post-kidney transplant thrombotic microangiopathy (KT-TMA) is a poor prognostic complication that causes a high rate of graft loss. In this study, we investigated KT-TMA-associated…
  • 2019 American Transplant Congress

    Effects of IVIG Therapy and FcγR Polymorphisms on BK Virus Nephropathy in Kidney Transplant Recipients

    D. I. Min1, Y. Chang2, T. Shah3

    1Western Univ of Health Sciences, Los Angeles, CA, 2Mendez National Institute of Transplantation Foundation, Los Angeles, CA, 3St. Vincent Medical Center, Los Angeles, CA

    *Purpose: BK Virus Nephropathy (BKVN) is a major complication in kidney transplant patients. Although standard treatment for BKVN is immunosuppression reduction and/or using leflunomide, studies…
  • 2019 American Transplant Congress

    What’s in a High Dose? An Analysis of Tacrolimus Pharmacokinetic Parameters in Rapid Metabolizers

    P. West-Thielke1, A. Maldonado2, S. J. Patel3, D. R. Stevens3, U. Meier-Kriesche3, D. Brennan4

    1University of Illinois, Chicago, Chicago, IL, 2Vidant Medical Center, Greenville, NC, 3Veloxis Pharmaceuticals Inc., Cary, NC, 4Johns Hopkins University School of Medicine, Baltimore, MD

    *Purpose: CYP3A5*1 expressers exhibit differences in immediate-release tacrolimus (IR-Tac) PK and require higher doses of IR-Tac to maintain therapeutic trough concentrations. LCP-Tacrolimus (LCPT) demonstrates a…
  • 2019 American Transplant Congress

    Tacrolimus Pharmacokinetics in Young, Middle Age and Older Renal Transplant Recipients- Impact of CYP3A5*3*6*7 Metabolic Composite

    K. Tornatore1, K. Attwood2, D. Brazeau3, R. Venuto4

    1University at Buffalo; School of Pharmacy, Buffalo, NY, 2Biostatistics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 3Marshall University; School of Medicine, Huntington, WV, 4University at Buffalo; School of Medicine, Buffalo, NY

    *Purpose: In spite of increased renal transplantation in patients over 60 years and the need for age-adjusted tacrolimus maintenance immunosuppression, limited pharmacokinetic comparisons between young,…
  • 2019 American Transplant Congress

    Polymorphisms in Mycophenolate Mofetil Glucuronidation Gene Are Associated with Leukopenia and Decreased CLAD-Free Survival

    A. Barnes, D. R. Calabrese, E. Henricksen, R. Florez, K. Dewey, P. Wang, J. Teraoka, K. Lien, S. Hays, J. P. Singer, J. Golden, J. Kukreja, J. R. Greenland

    UCSF Medical Center, San Francisco, CA

    *Purpose: Lung transplant recipients vary in their tolerance of the immunosuppressant mycophenolate mofetil (MMF). Single nucleotide polymorphisms (SNPs) in UDP-glucuronosyltransferase 2B7 (UGT2B7) increase conversion of…
  • 2019 American Transplant Congress

    Involvement of Genetic Variation and Related Gene Expression Changes on Acute Rejection in Renal Transplant Recipients

    H. Hwang1, J. Seo1, J. Kim1, Y. Kim1, J. Moon1, K. Jeong1, C. Kim2, J. Park3, B. Chung4, Y. Kim5, S. Lee1

    1Division of Nephrology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea, Republic of, 2Division of Nephrology, Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea, Republic of, 3Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of, 4Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea, Seoul, Korea, Republic of, 5Division of Nephrology, Department of Internal Medicine, College of Medicine, Inje University, Pusan, Korea, Republic of

    *Purpose: Acute rejection (AR) is one of the major risk factors for renal allograft loss. The effect of genetic factors on the transplant outcomes has…
  • 2018 American Transplant Congress

    Identification of Human SIRPa Diversity That Could Regulate Innate Allorecognition

    A. Friday,1 H. Dai,1 A. Williams,1 M. Oberbarnscheidt,1 J. Danska,2 F. Lakkis.1

    1Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA; 2Immunology and Medical Biophysics, University of Toronto, Toronto, ON, Canada.

    Innate allorecognition is a process by which myeloid cells, such as monocytes, distinguish syngeneic from allogeneic cells. Monocytes that recognize donor cells as non-self differentiate…
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