ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Gene polymorphism"

  • 2020 American Transplant Congress

    FcγRIIIb Inhibits Renal Transplant Rejection by Inducing Neutrophils Apoptosis

    J. Zhang, J. Chen

    Kidney Disease Center, The First Affiliated Hospital of Zhejiang University, Hangzhou, China

    *Purpose: Fcγ receptors (FcγR) have been proposed to be involved in the pathogenesis of acute rejection (AR) after organ transplantation. However, the mechanisms by which…
  • 2020 American Transplant Congress

    A Single Nucleotide Polymorphism of Tweak Predicts Arterio- and Arteriolohyalinosis in Kidney Transplants and is Associated with Allograft Survival

    A. Karolin1, D. Thottan1, J. Zinsli1, S. Rudloff1, U. Huynh-Do1, V. Banz2, T. Berney3, M. Pascual4, T. Müller5, P. d’Amico6, I. Binet7, D. Sidler1

    1Nephrology and Hypertension, University Bern, Bern, Switzerland, 2University Bern, Bern, Switzerland, 3University Hospital Genevia, Genevia, Switzerland, 4University Hospital Lausanne, Lausanne, Switzerland, 5University Hospital Zurich, Zurich, Switzerland, 6Hospital St.Gallen, St.Gallen, Switzerland, 7University Hospital Basel, Basel, Switzerland

    *Purpose: We have recently demonstrated that the TNF superfamily member is critical for the pathogenesis of Calcineurin Inhibitor Toxicity (CNT). CNT is a common side…
  • 2020 American Transplant Congress

    Impact of Donor Race on Tacrolimus Dose Requirement for Liver Transplant Recipients

    N. Nesselhauf1, S. January1, J. Hagopian1, K. Progar1, A. Khan2

    1Pharmacy, Barnes-Jewish Hospital, St. Louis, MO, 2Surgery, Washington University School of Medicine, St. Louis, MO

    *Purpose: It is well described that there is interpatient variability in tacrolimus dose requirements among transplant recipients. CYP3A5 plays a role in this variability. Black…
  • 2020 American Transplant Congress

    Attempted Validation of Lims1 Variant Rs893403 with Acute Rejection Risk

    W. S. Oetting1, G. Weihua1, C. R. Dorr1, R. B. Mannon2, A. J. Matas1, P. A. Jacobson1, A. K. Israni1

    1University of Minnesota, Minneapolis, MN, 2University of Alabama, Birmingham, AL

    *Purpose: Acute rejection (AR) in kidney allograft recipients is a significant risk factor for reduced graft survival. Identifying individuals at risk for AR could facilitate…
  • 2020 American Transplant Congress

    Pre-Transplant Pharmacogenetics Identifies CYP3A4 and CYP3A5 Heterogeneity among Caucasian Kidney Transplant Recipients

    N. Oliver1, L. Lindberg1, S. LeCorchick1, D. Morris1, S. Anand1, T. Srinivas2

    1Intermountain Medical Center, Murray, UT, 2University Hospitals Cleveland Medical Center, Cleveland, OH

    *Purpose: Tacrolimus has always been dosed based on therapeutic drug monitoring, however pharmacogenomics is becoming increasingly more utilized in the era of precision based medicine…
  • 2019 American Transplant Congress

    Phylogenetic Analysis of the Epstein Barr Virus Nuclear Antigen-1 and Associated Correlates among Canadian Transplant Patients

    M. Abdulnoor1, S. Isabel1, T. Paton1, N. Khodai-Booran1, T. Schechter1, P. Birk2, T. Blydt-Hansen3, B. Foster4, S. Mital1, V. Phan5, S. Urschel6, G. Casallo1, T. Papaz1, L. Hamiwka7, S. Min1, U. Allen1

    1University of Toronto, Toronto, ON, Canada, 2University of Manitoba, Winnipeg, MB, Canada, 3University of British Columbia, Vancouver, BC, Canada, 4McGill University, Montreal, QC, Canada, 5University of Montreal, Montreal, QC, Canada, 6University of Alberta, Edmonton, AB, Canada, 7University of Calgary, Calgary, AB, Canada

    *Purpose: The effect of the genetic diversity of the Epstein-Barr virus (EBV) on clinical outcomes in the transplant setting is important to study. We examined…
  • 2019 American Transplant Congress

    Studying the Association of Melanocortin Receptor-4 Gene Polymorphism and Renal Transplant Rejection

    F. Yilmaz1, R. Abdi1, B. J. Keating2, V. R. Mas3

    1Renal Division, Transplantation Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 2Surgery, Perelman School of Medicine University of Pennsylvania, Philadelphia, PA, 3Director Transplant Research Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN

    *Purpose: Accumulating experimental data highlight the importance of targeting the innate immune response to improve transplant outcomes. Inflammation is an unavoidable consequence of transplantation. The…
  • 2019 American Transplant Congress

    CNV Screening For End-stage Renal Disease

    C. E. Fishman, B. Chang, A. Shaked, B. J. Keating

    Surgery, University of Pennsylvania, Philadelphia, PA

    *Purpose: The prevalence of ESRD in the United States was 2,160.7 cases per one million individuals in 2016, and a primary cause of ESRD was…
  • 2019 American Transplant Congress

    Relationship between HLA-DPB1 Gene Expression in Pre-Implantation Kidney Biopsies, Rs9277534 Polymorphism, and Late Graft Function

    K. L. Mine1, T. B. Mourão1, C. Felipe2, G. F. Rampim1, J. O. Medina-Pestana2, H. Tedesco-Silva2, M. Gerbase-DeLima1

    1Immunogenetics Institute, Associação Fundo de Incentivo a Pesquisa - AFIP, Sao Paulo, SP, Brazil, 2Hospital do Rim, Sao Paulo, SP, Brazil

    *Purpose: A previous gene expression microarray study in pre-implantation biopsies (PIB) from kidneys of adult deceased donors (D) showed association between high class II HLA…
  • 2019 American Transplant Congress

    Combined Pre-Transplant Anti-Donor T-Cell Sensitization with Single Nucleotid Polimorphisms (SNPs) for CYP3A4 Tacrolimus Metabolism Identifies Kidney Transplant Patients at High Risk of Allograft Rejection

    E. Crespo1, A. Vidal1, A. Sefrin2, P. Fontova1, M. Stein2, H. Volk2, J. Grinyó3, P. Reinke2, N. Lloberas1, O. Bestard3

    1Experimental Nephrology Laboratory, IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain, 2Nephrology, Charité Campus Virchow-Klinikum, Berlin, Germany, 3Kidney Transplant Unit, Bellvitge University Hospital- IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain

    *Purpose: Preformed donor-specific (d-sp) T-cell alloimmunity has been associated to high risk of acute rejection (BPAR). Since the individual susceptibility related to specific single nucleotide…
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