Articles tagged "Gene polymorphism"

2020 American Transplant Congress
A Single Nucleotide Polymorphism of Tweak Predicts Arterio- and Arteriolohyalinosis in Kidney Transplants and is Associated with Allograft Survival
A. Karolin¹, D. Thottan¹, J. Zinsli¹, S. Rudloff¹, U. Huynh-Do¹, V. Banz², T. Berney³, M. Pascual⁴, T. Müller⁵, P. d’Amico⁶, I. Binet⁷, D. Sidler¹
¹Nephrology and Hypertension, University Bern, Bern, Switzerland, ²University Bern, Bern, Switzerland, ³University Hospital Genevia, Genevia, Switzerland, ⁴University Hospital Lausanne, Lausanne, Switzerland, ⁵University Hospital Zurich, Zurich, Switzerland, ⁶Hospital St.Gallen, St.Gallen, Switzerland, ⁷University Hospital Basel, Basel, Switzerland
*Purpose: We have recently demonstrated that the TNF superfamily member is critical for the pathogenesis of Calcineurin Inhibitor Toxicity (CNT). CNT is a common side…
2020 American Transplant Congress
Impact of Donor Race on Tacrolimus Dose Requirement for Liver Transplant Recipients
N. Nesselhauf¹, S. January¹, J. Hagopian¹, K. Progar¹, A. Khan²
¹Pharmacy, Barnes-Jewish Hospital, St. Louis, MO, ²Surgery, Washington University School of Medicine, St. Louis, MO
*Purpose: It is well described that there is interpatient variability in tacrolimus dose requirements among transplant recipients. CYP3A5 plays a role in this variability. Black…
2020 American Transplant Congress
Attempted Validation of Lims1 Variant Rs893403 with Acute Rejection Risk
W. S. Oetting¹, G. Weihua¹, C. R. Dorr¹, R. B. Mannon², A. J. Matas¹, P. A. Jacobson¹, A. K. Israni¹
¹University of Minnesota, Minneapolis, MN, ²University of Alabama, Birmingham, AL
*Purpose: Acute rejection (AR) in kidney allograft recipients is a significant risk factor for reduced graft survival. Identifying individuals at risk for AR could facilitate…
2020 American Transplant Congress
Pre-Transplant Pharmacogenetics Identifies CYP3A4 and CYP3A5 Heterogeneity among Caucasian Kidney Transplant Recipients
N. Oliver¹, L. Lindberg¹, S. LeCorchick¹, D. Morris¹, S. Anand¹, T. Srinivas²
¹Intermountain Medical Center, Murray, UT, ²University Hospitals Cleveland Medical Center, Cleveland, OH
*Purpose: Tacrolimus has always been dosed based on therapeutic drug monitoring, however pharmacogenomics is becoming increasingly more utilized in the era of precision based medicine…
2020 American Transplant Congress
Precision Dosing for Tacrolimus Using Genotypes and Clinical Factors
M. Al-Kofahi¹, W. Oetting¹, A. Israni², D. Schladt³, W. Guan⁴, B. Wu⁴, C. Dorr⁵, R. Remmel⁶, R. Mannon⁷, N. Pankratz⁸, A. Matas⁹, P. Jacobson¹
¹Experimental and Clinical Pharmacology, Univ of MN, College of Pharmacy, Minneapolis, MN, ²Nephrology, Univ of MN and Hennepin HealthCare, Minneapolis, MN, ³Hennepin HealthCare Research Institute, Hennepin HealthCare, Minneapolis, MN, ⁴Biostatistics, Univ of MN, Minneapolis, MN, ⁵Nephrology, Hennepin HealthCare, Minneapolis, MN, ⁶Medicinal Chemistry, Univ of MN, College of Pharmacy, Minneapolis, MN, ⁷Nephrology, Univ of Alabama, Minneapolis, MN, ⁸Lab Medicine Pathology, Univ of MN, Minneapolis, MN, ⁹Surgery, Univ of MN, Minneapolis, MN
*Purpose: Variants in CYP3A4/5 genes, clinical factors and drug-drug interactions are associated with tacrolimus (TAC) clearance and dose. This results in high intra- and inter-…
2019 American Transplant Congress
Evaluation Of Complement-related Factors In Tma Post-kidney Transplantation: A Retrospective Multicenter Study
N. Fujiyama¹, M. Tasaki², H. Harada³, K. Tsutahara⁴, A. Matsumoto⁵, Y. Hara⁶, M. Okumi⁷, K. Saito², Y. Watarai⁸, N. Inoue⁹, N. Wakamiya⁹, S. Satoh¹
¹Center for Kidney Disease and Transplantaion, Akita University Hospital, Akita, Japan, ²Department of Urology, Niigata University, Niigata, Japan, ³Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Japan, ⁴Department of Urology, Osaka General Medical Center, Osaka, Japan, ⁵Department of Urology, The University of Tokyo, Tokyo, Japan, ⁶Department of Nephrolog, Shinsyu University Hospital, Shinsyu, Japan, ⁷Department of Urology, Tokyo Women’s Medical University, Tokyo, Japan, ⁸Department of Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan, ⁹The Japanese Association for Complement Research, Osaka, Japan
*Purpose: Post-kidney transplant thrombotic microangiopathy (KT-TMA) is a poor prognostic complication that causes a high rate of graft loss. In this study, we investigated KT-TMA-associated…
2019 American Transplant Congress
Effects of IVIG Therapy and FcγR Polymorphisms on BK Virus Nephropathy in Kidney Transplant Recipients
D. I. Min¹, Y. Chang², T. Shah³
¹Western Univ of Health Sciences, Los Angeles, CA, ²Mendez National Institute of Transplantation Foundation, Los Angeles, CA, ³St. Vincent Medical Center, Los Angeles, CA
*Purpose: BK Virus Nephropathy (BKVN) is a major complication in kidney transplant patients. Although standard treatment for BKVN is immunosuppression reduction and/or using leflunomide, studies…
2019 American Transplant Congress
What’s in a High Dose? An Analysis of Tacrolimus Pharmacokinetic Parameters in Rapid Metabolizers
P. West-Thielke¹, A. Maldonado², S. J. Patel³, D. R. Stevens³, U. Meier-Kriesche³, D. Brennan⁴
¹University of Illinois, Chicago, Chicago, IL, ²Vidant Medical Center, Greenville, NC, ³Veloxis Pharmaceuticals Inc., Cary, NC, ⁴Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: CYP3A5*1 expressers exhibit differences in immediate-release tacrolimus (IR-Tac) PK and require higher doses of IR-Tac to maintain therapeutic trough concentrations. LCP-Tacrolimus (LCPT) demonstrates a…
2019 American Transplant Congress
Tacrolimus Pharmacokinetics in Young, Middle Age and Older Renal Transplant Recipients- Impact of CYP3A5*3*6*7 Metabolic Composite
K. Tornatore¹, K. Attwood², D. Brazeau³, R. Venuto⁴
¹University at Buffalo; School of Pharmacy, Buffalo, NY, ²Biostatistics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, ³Marshall University; School of Medicine, Huntington, WV, ⁴University at Buffalo; School of Medicine, Buffalo, NY
*Purpose: In spite of increased renal transplantation in patients over 60 years and the need for age-adjusted tacrolimus maintenance immunosuppression, limited pharmacokinetic comparisons between young,…
2019 American Transplant Congress
Polymorphisms in Mycophenolate Mofetil Glucuronidation Gene Are Associated with Leukopenia and Decreased CLAD-Free Survival
A. Barnes, D. R. Calabrese, E. Henricksen, R. Florez, K. Dewey, P. Wang, J. Teraoka, K. Lien, S. Hays, J. P. Singer, J. Golden, J. Kukreja, J. R. Greenland
UCSF Medical Center, San Francisco, CA
*Purpose: Lung transplant recipients vary in their tolerance of the immunosuppressant mycophenolate mofetil (MMF). Single nucleotide polymorphisms (SNPs) in UDP-glucuronosyltransferase 2B7 (UGT2B7) increase conversion of…