2022 American Transplant Congress
A Pathway for Establishing Etiology of Kidney Failure: An Academic Transplant Center’s Experience with a Broad Kidney Gene Panel
1Loyola University Medical Center, Maywood, IL, 2Natera, Inc., Austin, TX
*Purpose: Assessing genetic causes of kidney failure can inform pre-transplant decision making and may improve post-transplant outcomes. Here we describe an academic transplant center’s experience…2022 American Transplant Congress
Protocolized, Broad-Based Renal Genetic Testing in the Management of Patients at a Transplant Center
*Purpose: Studies show that ~10% of adult chronic kidney diseases (CKD) cases have genetic etiologies. In the nephrology setting, the use of a broad, unbiased…2021 American Transplant Congress
A Single Nucleotide Polymorphism within the FCGR3A 158 F/V Gene is Associated with Decreased Survival of Renal Allografts with Chronic Active Antibody-Mediated Rejection
*Purpose: Long-term allograft survival has shown little improvement over the last decades. An important factor compromising long-term allograft survival in kidney transplantation is chronic active…2021 American Transplant Congress
Cyp3a5 Extensive Metabolizer Phenotype May be Associated with an Increase in Class 2 Donor Specific Antibodies and Antibody-Mediated Rejection
*Purpose: Tacrolimus (TAC) metabolism is highly dependent on CYP3A5, yet there is limited data on the effect of CYP3A5 genetic polymorphisms in heart transplant recipients…2021 American Transplant Congress
Higher Number of Tacrolimus Dose Adjustments and Trough Level Measurements in Kidney Transplant Recipients with CYP3A5*1 Alleles
*Purpose: Tacrolimus (TAC) metabolism is dependent on the functional status of the cytochrome P450 family enzyme CYP3A5 which has three common loss of function (LoF)…2021 American Transplant Congress
Extreme Phenotype Sampling and Next Generation Sequencing to Identify Genetic Variants Associated with Tacrolimus Metabolism in African American Kidney Transplant Recipients
*Purpose: Tacrolimus (TAC) pharmacogenomics studies identified common genetic variants that alter TAC troughs suggesting strategic dosing for specific populations. Common variants and clinical factors explain…2020 American Transplant Congress
Attempted Validation of Lims1 Variant Rs893403 with Acute Rejection Risk
1University of Minnesota, Minneapolis, MN, 2University of Alabama, Birmingham, AL
*Purpose: Acute rejection (AR) in kidney allograft recipients is a significant risk factor for reduced graft survival. Identifying individuals at risk for AR could facilitate…2020 American Transplant Congress
Pre-Transplant Pharmacogenetics Identifies CYP3A4 and CYP3A5 Heterogeneity among Caucasian Kidney Transplant Recipients
*Purpose: Tacrolimus has always been dosed based on therapeutic drug monitoring, however pharmacogenomics is becoming increasingly more utilized in the era of precision based medicine…2020 American Transplant Congress
Precision Dosing for Tacrolimus Using Genotypes and Clinical Factors
*Purpose: Variants in CYP3A4/5 genes, clinical factors and drug-drug interactions are associated with tacrolimus (TAC) clearance and dose. This results in high intra- and inter-…2020 American Transplant Congress
Gasdermin-D Mutation is Protective against Renal Ischemia Reperfusion Injury
*Purpose: Pyroptosis, a pro-inflammatory form of cell death, is dependent on membrane pore formation through the assembly of cleaved Gasdermin-D molecules. We hypothesized that this…
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