Articles tagged "Gene expression"

2016 American Transplant Congress
ESM1 Gene Promotes Hepatocyte Proliferation Through NF-κB Signal Pathway.
J. Zhou, W. Ju, X. Jiao, X. Zhu, X. He.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
BACKGROUND: Effective and timely liver regeneration is pivotal in the prevention of fetal small-for-size syndrome after living donor liver transplantation or split liver transplantation. Our…
2016 American Transplant Congress
Transcriptome Profiles in Peripheral Blood of Kidney Graft Recipients.
J.-W. Seo,¹ H. Moon,¹ Y.-G. Kim,¹ K.-H. Jeong,¹ S.-J. Ihm,² J.-Y. Moon,¹ S.-H. Lee.¹
¹Division of Nephrology, Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul, Republic of Korea; ²Department of Pathology, Kyung Hee University College of Medicine, Seoul, Republic of Korea.
The discovery of sensitive noninvasive diagnosis and the development of immune management in the renal allograft recipients are required for long-term graft survival. Although the…
2016 American Transplant Congress
IL-17A Preactivated Mesenchymal Stem Cells (MSC-17) Are Enriched for Genes Involved in T Cell Chemotaxis to Mediate Superior Immunosuppression.
K. Sivanathan,^1,2,3 D. Rojas-Canales,^1,2 S. Gronthos,⁴ S. Grey,⁵ P. Coates.^1,2,3
¹School of Medicine, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia; ²Centre for Clinical and Experimental Transplantation, Royal Adelaide Hospital, Adelaide, South Australia, Australia; ³Centre for Stem Cell Research and Robinson Institute, School of Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia; ⁴Mesenchymal Stem Cell Laboratory, School of Medicine, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia; ⁵Transplant Immunology Group, Garvin Institute of Medical Research, Sydney, New South Wales, Australia.
Human bone marrow derived MSC-17 are superior T cell immunomodulators for allotransplantation. Untreated-MSC (UT-MSC) or 5 days IFNγ (MSCγ) or IL-17A (MSC-17) treated MSC were…
2016 American Transplant Congress
Natural History of Response to Wounding in Human Kidney Transplants.
K. Famulski,¹ J. Venner,^2,1 J. Reeve,¹ P. Halloran.¹
¹University of Alberta, Edmonton, AB, Canada; ²University of Queensland, Brisbane, Queensland, Australia.
In both primary kidney diseases and kidney transplants, the extent of fibrosis is a key indicator of stage, progression, and prognosis. Much debate focuses, however,…
2016 American Transplant Congress
The Urine Common Rejection Module (uCRM) Is a Sentinal Assay for Graft Rejection.
T. Sigdel,¹ T. Tran,¹ O. Bestard,² F. Vincenti,¹ M. Sarwal.¹
¹Surgery, UCSF, San Francisco, CA; ²Nephrology, Bellevitage Hospital, Barcelona, Spain.
Background: A common rejection module (CRM) consisting of 11 genes are expressed in solid organ transplant rejection in kidney, heart, liver and lung transplantation (Khatri,…
2016 American Transplant Congress
Intragraft Molecular Pathways Associated with Tolerance Induction in Renal Transplantation.
L. Gallon,¹ J. Leventhal,¹ C. Dumur,² J. Mathew,¹ L. Nadimpalli,¹ A. Shetty,¹ S. Ildstad,³ V. Mas.²
¹Medicine/Nephrology, Northwestern University, Chicago, IL; ²Medicine/Nephology, University of Virginia Health System, Charlottesville, VA; ³Immunology, University of Louisville, Louisville, KT.
Organ transplantation relies upon nonspecific immunosuppressive (IS) agents to prevent graft rejection. However, IS drugs have significant toxicities and chronic rejection occurs despite their usage.…
2016 American Transplant Congress
Molecular Significance of Microvascular Inflammation and C4d Negative Transplant Glomerulopathy.
M. Lubetzky,¹ P. O Broin,² Y. Bao,¹ E. Akalin.¹
¹Transplantation, Albert Einstein College of Medicine, Bronx; ²School of Mathematics, Statistics & Applied Mathematics, National University of Ireland Galway University, Galway, Ireland.
Background: Transplant glomerulopathy (TGP) is frequently found in the setting of chronic antibody mediated rejection along with microvascular inflammation (MVI) (peritubular capillaritis+glomerulitis score > 1)…
2016 American Transplant Congress
Long Term Heterotopic Cardiac Xenograft Survival from Donor Pigs with Six Gene Modifications.
M. Mohiuddin,¹ A. Singh,¹ J. Chan,¹ P. Corcoran,¹ M. Thomas III,² B. Lewis,² D. Ayares,³ K. Horvath.¹
¹CSRP, NHLBI/NIH, Bethesda, MD; ²DVR / RS, NIH, Bethesda, MD; ³Revivicor, Inc, Blacksburgh, VA.
Introduction: We have recently reported pig xenograft survival of more than 2.5 years in a heterotopic cardiac xenograft model. Some of the animals exhibited local…
2016 American Transplant Congress
Circulating miR-215, miR-let-7c miR-154, miR-193a, NR_036506.1 and NR_027669.1 as Biomarkers Predict Fungal Infection in Post-Transplanted Recipients.
A. Yang, Z. Guo, W. Ju, C. Zhang, Z. Li, X. Yuan, Q. Zhao, H. Ye, Y. Liao, X. Zhu, X. He.
Organ Transplantation Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Aims: The incidence of fungal infection in post-transplanted patients is 13%-17%, which seriously effecting perioperative survival and increasing their economic burden. We wanted to find…
2016 American Transplant Congress
Effect of Complement Inhibition Therapy (Eculizumab) in Patients with C1q-Binding Donor-Specific Anti-HLA Antibodies: A Molecular Appraisal.
C. Lefaucheur,¹ L. Hidalgo,² J. Reeve,² D. Viglietti,¹ C. Gosset,¹ O. Aubert,³ C. Ulloa,³ C. Legendre,³ D. Glotz,¹ P. Halloran,² A. Loupy.³
¹Saint-Louis Hospital, Paris, France; ²University of Alberta, Edmonton, Canada; ³Necker Hospital, Paris, France.
Complement-binding anti-HLA DSA have demonstrated higher rejection rate and decreased allograft outcome. We investigated the effect of terminal complement inhibition (Eculizumab) in a cohort of…