2022 American Transplant Congress
Gene Expression Changes Including Long Non-Coding RNAs in Human Hepatic Ischemia Reperfusion Injury
*Purpose: Ischemia reperfusion injury (IRI) is still one of the major problems in liver transplantation affecting long term outcomes. This study is sought out to…2022 American Transplant Congress
Single-Cell RNA Sequencing Identifies the Changes of Human Normal Kidney After Transplantation
*Purpose: We found that in all studies about kidney transplantation and single cell RNA sequencing (scRNA-seq), the native kidney rather than the transplanted kidney was…2022 American Transplant Congress
Kidney Grafts with Poor 24-Month Function Present Upregulated Immune Activity at Pre-Transplantation
*Purpose: A transcriptomic profile serves as a snapshot of the temporary cell state and thus, analyzing pretransplant kidney biopsies can provide detailed information on the…2022 American Transplant Congress
The Role Of Gut Microbiome In Optimum Dose Selection Of Tacrolimus For Kidney Transplant Recipients
1George Mason University, Arlington, VA, 2George Washington University Hospital, Washington, DC
*Purpose: This study aims to validate and apply a personalized optimal dose selection model for Tacrolimus (Tac) for kidney transplant recipients at the George Washington…2022 American Transplant Congress
Investigating RNA Interference-Mediated Inhibition of Liver Ischemia Reperfusion Injury During Liver Preservation
*Purpose: Liver transplantation cures acute end-stage and chronic liver diseases, yet current strategies of organ preservation including static cold storage (SCS) and machine perfusion (MP)…2022 American Transplant Congress
Gene Expression Profiles of Peritubular Capillarits in Chronic Antibody-Mediated Rejection
*Purpose: Antibody-mediated rejection (ABMR) is one of the most significant contributors to late graft loss. Hallmark characteristics include peritubular capillaritis (ptc) and glomerulitis (g). Diffuse…2022 American Transplant Congress
A Signature of Tolerance Which Identifies Subclinical Rejection-Free Patients at One Year After Kidney Transplantation
*Purpose: Spontaneous and rare cases of patients undergoing a functional renal transplant in the absence of immunosuppression represent a particular situation of immune tolerance. We…2022 American Transplant Congress
Technology-Driven Performance Improvement of a Biomarker Panel in Kidney Transplant: OmniGraf
*Purpose: Analyze the impact of the transition from TruGraf microarray to TruGraf PCR on the complementary performance characteristics of TruGraf plus TRAC (OmniGraf).*Methods: Development of…2022 American Transplant Congress
Establishment And Validation Of A Predictive Model For Differential Rejection Diagnosis By Gene Expression Profiling (GEP) In Renal Allograft Biopsies Using Banff Human Organ Transplant (B-HOT) Gene Panel
1CareDx, Inc., Brisbane, CA, 2Arkana Laboratories, Little Rock, AR
*Purpose: Large scale GEP studies evaluating the performance of Banff-endorsed B-HOT gene panel for allograft rejection diagnosis have not been published. In this study, we…2022 American Transplant Congress
Protein and Transcriptomic Differences Between High and Low Neointimal Arteries in Human Cardiac Allograft Vasculopathy Rejected Grafts
*Purpose: Cardiac allograft vasculopathy (CAV) is the leading cause of graft failure and mortality following heart transplantation. Donor specific antibodies (DSA) contribute to CAV progression…
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