2019 American Transplant Congress
Organ Resilience Contributes to Different Impact of Delayed Graft Function (DGF) on Graft Survival in Kidneys Donated by Brain Death (DBD) and Circulatory Death Donors (DCD)
Transplantation Center, LUMC, Leiden, Netherlands
*Purpose: Despite a tripled higher incidence of DGF in DCD kidney grafts compared to DBD kidney grafts, large studies show equivalent long-term graft survival with…2019 American Transplant Congress
RNA Sequencing Identifies a Differential Role of Coding and Non-Coding Genes by Types of Rejection
*Purpose: The differentiation of histological phenotypes of T cell mediated cellular rejection (TCMR) and humoral or antibody mediated rejection (AMR) of kidney allografts, bears relevance…2019 American Transplant Congress
The Molecular Pathology of Immune Checkpoint Inhibitor-Associated Renal Allograft Rejection: Overlap with Acute Interstitial Nephritis
*Purpose: The use of immune checkpoint inhibitors (ICIs) for various malignancies has been associated with numerous immunological adverse events, including acute interstitial nephritis (AIN) in…2018 American Transplant Congress
Results of LITMUS (NCT 02541916): The Liver Immune Tolerance Bio Marker Utilization Study
Background: Previously we reported a novel biomarker gene set for the identification of tolerance in murine models of rapamycin-induced cardiac tolerance and spontaneous hepatic tolerance.…2018 American Transplant Congress
β-Glucuronidase Gene Expression in Stool Samples Associated with Chronic Allograft Dysfunction in Kidney Transplants
Background: Myocophenolate mofetil (MMF) is a prodrug that is extensively and rapidly converted to the active component, mycophenolic acid (MPA). MPA undergoes extensive enterohepatic recycling…2018 American Transplant Congress
Intragraft MicroRNAs Foretell Fibrosis in Kidney Transplant Recipients
BackgroundIdentifying biomarkers that anticipate tubulointerstitial fibrosis (IFTA) of the kidney allograft will be a transformative advance.Aim/HypothesisIntragraft microRNA profile of 3-month surveillance biopsies reported as normal…2018 American Transplant Congress
Novel Approach to Molecular Testing Using Routine Diagnostic Tissue
1University of Glasgow, Glasgow, United Kingdom; 2Columbia University, New York.
Currently, molecular diagnostics in kidney transplantation requires dedicated fresh tissue. This requirement limits use in mainstream clinical settings due to perceived increased patient risk in…2018 American Transplant Congress
mRNA Transcript Profiles of 14 Genes in Plasma Exosome Predict Risk for Antibody-Mediated Rejection (ABMR) of Renal Allografts
Background: Previously we reported that mRNA transcript profiles of 4 genes (gp130, SH2D1B, TNFα and CCL4) in plasma exosome could predict the risk of ABMR,…2018 American Transplant Congress
In-Situ Tissue-Based Gene Expression Profiling is a Reliable Method to Detect Gene Transcripts in Human Kidney Transplant Biopsies
Purpose. Validation studies that would enable the clinical application of quantitative in situ tissue-based gene expression profiling in renal transplantation are lacking. In this study,…2018 American Transplant Congress
Modification of Macrophage Phenotype by the Magnetic Field
Objective. Macrophages play a crucial role in health, disease and chronic rejection of transplanted organs. Chronic rejection of transplanted organs remains unresolved issue in organ…
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