Articles tagged "Gene expression"

2019 American Transplant Congress
Cell Coding Transcriptomic Analysis Of Serial Blood And Biopsy Samples In A Large Cohort Of Kidney Transplant Recipients
W. Zhang¹, Z. Yi¹, Z. Sun¹, K. Keung², C. Wei¹, C. Xi¹, S. Farouk¹, M. Menon¹, P. Cravedi¹, P. O'Connell², B. Murphy¹
¹Icahn School of Medicine at Mount Sinai, New York, NY, ²The University of Sydney, Sydney, Australia
*Purpose: Whole blood and graft biopsy RNA expression analyses are limited by the heterogeneous cell composition of the samples. Cell coding is an analytical tool…
2019 American Transplant Congress
Interferon Sensitivity Promotes Recovery from Acetaminophen Induced Liver Injury
S. Datta, T. Hamilton, G. C. Sen
Inflammation and Immunity, Cleveland Clinic Foundation, Cleveland, OH
*Purpose: The current study was undertaken to assess the role of inflammatory signaling during induction of and recovery from acetaminophen induced acute liver failure.*Methods: C57BL/6…
2019 American Transplant Congress
Pluripotent Stem Cell Differentiation: Delaying Forward Differentiation Signals Maintains Definitive Endoderm Phenotype for Cellular Transplantation
J. Fair¹, M. M. Shoja¹, N. Liu¹, I. Patrikeev², M. Motamedi², W. S. Fagg¹
¹Surgery, University of Texas Medical Branch, Galveston, TX, ²Opthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, TX
*Purpose: Endodermal precursors (EP), derived in vitro from mouse pluripotent stem cell (PSC) sources, are capable of clinically useful engraftment in the unmodified (quiescent) liver…
2018 American Transplant Congress
Identification of Noninvasive and Mechanistically-Informative Biomarkers Predictive of Reversal of Acute Cellular Rejection (ACR) in Kidney Allografts
D. Luan,¹ J. Schwartz,² R. Ding,² T. Muthukumar,² D. Dadhania,² M. Suthanthiran.²
¹University of Michigan, Ann Arbor, MI; ²Weill Cornell Medical College, New York City, NY.
Objective: We determined whether urinary cell mRNAs predict response to anti-rejection therapy in kidney allograft recipients with Banff grade IA or higher ACR biopsies.Methods: We…
2018 American Transplant Congress
Renal Allograft Molecular Pathways Associated with Tolerance Induction in Renal Transplantation
L. Gallon,¹ J. Mathew,¹ S. Bontha,² C. Dumur,² P. Dalal,¹ L. Nadimpalli,¹ D. Maluf,² A. Shetty,¹ S. Ildstad,³ J. Leventhal,¹ V. Mas.²
¹Department of Medicine-Nephrology, Northwestern University, Chicago, IL; ²Department of Surgery, University of Virginia, Charlottesville, VA; ³Departments of Surgery, Physiology and Immunology, University of Louisville, Louisville, KY.
Background: Chronic exposure to immunosuppressive agents for organ transplant results in graft nephrotoxicity, infections and malignancies We have established durable immune tolerance in mismatched related…
2018 American Transplant Congress
Intragraft Gene Expression Differentiates Polyomavirus Nephropathy from T-Cell Mediated Rejection
B. Adam,¹ S. Wagner,¹ J. Bräsen,² V. Bröcker,² V. D'Agati,³ C. Drachenberg,⁴ E. Farkash,⁵ A. Farris,⁶ L. Geldenhuys,⁷ A. Magil,⁸ V. Nickeleit,⁹ P. Randhawa,¹⁰ H. Regele,¹¹ M. Mengel.¹
¹University of Alberta, Edmonton, Canada; ²Hannover Medical School, Hannover, Germany; ³Columbia University, New York; ⁴University of Maryland, College Park; ⁵University of Michigan, Ann Arbor; ⁶Emory University, Atlanta; ⁷Dalhousie University, Halifax, Canada; ⁸University of British Columbia, Vancouver, Canada; ⁹University of North Carolina, Chapel Hill; ¹⁰University of Pittsburgh, Pittsburgh; ¹¹Medical University of Vienna, Vienna, Austria.
Background: Improved immunosuppression protocols have reduced the incidence of T-cell mediated rejection (TCMR) but still carry a significant risk of BK polyomavirus nephropathy (BKVN). Despite…
2018 American Transplant Congress
Changes in Gene Expression of Selected Genes in Patient with Type 1 Diabetes in Peripheral Blood
M. Klak, J. Cichoń, F. Ambrożkiewicz, A. Berman, M. Serwańska-Świętek, M. Wszoła.
Foundation for Research and Science Development, Warsaw, Poland.
Insulin, a main anabolic peptide hormone, regulates metabolism of carbohydrates, proteins, lipids and affects DNA synthesis or apoptosis. Lack of insulin secretion by destroyed beta…
2018 American Transplant Congress
Expression of the Senescence Marker P16/INK4A in Kidney Implantation Biopsies is Uniquely Associated with Poor Late Graft Function
K. Famulski, P. Halloran.
University of Alberta, Edmonton, Canada.
With the aging donor population, accurate assessment of tissue quality of deceased donor kidneys is required to determine the intermediate and long term graft performance,…
2018 American Transplant Congress
Predicting Pediatric Liver Transplant Rejection with Peripheral Blood Leukocyte (PBL) Transcripts-Considerations and Design Limitations
M. Ningappa, C. Ashokkumar, Q. Sun, B. Higgs, K. Soltys, G. Bond, G. Mazariegos, R. Sindhi.
Pediatric Abdominal Transplant, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.
Background: Optimizing immunosuppression requires individualized rejection-risk assessment in children with liver transplantation (LTx). PBL transcripts are a desirable non-invasive solution. Purpose: To characterize PBL transcriptome…
2018 American Transplant Congress
PD-L1 May Serve as a Biomarker for Chimerism-Induced Tolerance in Kidney Transplant Recipients
A. Merchak,¹ A. Khalil,¹ A. Chhabra,¹ J. Leventhal,² S. Ildstad.¹
¹University of Louisville, Louisville, KY; ²Northwestern Memorial Hospital, Chicago, IL.
Durable chimerism is currently the most reliable biomarker of donor specific tolerance. Identifying and validating other predictive biomarkers is therefore a high priority. Since 2009…