2019 American Transplant Congress
Transcriptome Profiling Of Renal Transplant Biopsies With Acute Cellular Rejection From Patients On Calcineurin Inhibitor-based Or Cni-avoidance Immunosuppression
*Purpose: Despite their suboptimal toxicity profile, calcineurin-inhibitors (CNIs) remain the cornerstone of renal transplant immunosuppression. Previous efforts to completely eliminate CNIs failed, because CNI-avoidance protocols…2019 American Transplant Congress
The Negative Costimulatory Pd-1/pd-l1 Pathway Is Upregulated In Early Cell-mediated Rejection
Cleveland Clinic Main Campus, Lerner Research Institute, Cleveland, OH
*Purpose: Extensive transcript analysis has been performed on grafts at the time of rejection, but gene expression preceding overt rejection is less well studied.*Methods: We…2019 American Transplant Congress
Organ-Specific Injury and Recovery Mechanisms in Post-Transplant Ischemia Reperfusion Injury
*Purpose: Ischemia reperfusion (I/R) injury is a major contributor to short-term graft function. Dissecting organ specific and common molecular pathways associated with I/R injury among…2018 American Transplant Congress
Chronic Antibody Mediated Rejection in Renal Allografts Shows RNA Transcript Patterns That Evolve with Stage
1Massachusetts General Hospital, Boston, MA; 2University of Alberta, Edmonton, AB, Canada.
Purpose. Four stages of chronic antibody mediated rejection (CAMR) in renal allografts have been defined in humans and non-human primates (NHP), beginning with donor specific…2018 American Transplant Congress
Molecular Classifiers Can Outperform the Flawed Histologic “Gold Standard” on Which They Are Trained
University of Alberta, Edmonton, Canada.
The histologic diagnosis of rejection in organ transplants is known to be an imperfect gold standard. Therefore, it might be assumed that molecular classifiers built…2018 American Transplant Congress
Defective Innate Immune Response to Opportunistic Pathogens in Cytomegalovirus-Infected Monocytes
Human cytomegalovirus (CMV) is the most common infection encountered in transplantation and is an important cause of morbidity and mortality in both solid organ and…2018 American Transplant Congress
Molecular Analysis of Acute Cellular Rejection in Clinical Face Transplants
Brigham and Women's Hospital, Boston.
Although monitoring and immunosuppression of vascularized composite allografts (VCA) draw experience from solid organ transplantation, VCAs pose unique challenges. A deeper understanding of mechanisms underlying…2018 American Transplant Congress
Whole-Transcriptome Sequencing to Identify Macaque Immune Gene Variants
Macaque monkeys are critical in transplantation studies, yet macaque genomics lags significantly behind human genomics. While reliable genotyping methods have been developed for some macaque…2018 American Transplant Congress
mRNA Transcript Profiling of 3 Genes in Renal Allograft Biopsies (Bx) Improves Accuracy of Antibody-Mediated Rejection (ABMR) Diagnosis in Transplant Recipients Desensitized with IVIG+Rituximab+Immunoglobulin G-Degrading Enzyme of Streptococcus Pyogenes (IdeS)
Background: Multiple molecular signatures specific to ABMR based on gene expression in renal allograft Bx of transplant recipients were reported. Here we assessed mRNA transcript…2018 American Transplant Congress
Predictors of Graft Survival at the Time of a Kidney Transplant Indication Biopsy
We predicted kidney transplant graft survival after indication biopsy in 884 patients. Analysis was performed using random forests, a multivariate machine learning method to assess…
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