Articles tagged "Gene expression"

2019 American Transplant Congress
Immunomics of Renal Allograft Acute T-Cell Mediated Rejection Biopsies of Tacrolimus- and Belatacept- Treated Patients
M. van der Zwan¹, C. C. Baan¹, R. C. Colvin², R. N. Smith², R. A. White², D. N. Ndishabandi², A. L. Nigg¹, T. P. van den Bosch¹, G. N. de Graav¹, M. C. Clahsen-van Groningen¹, D. A. Hesselink¹
¹Internal Medicine, Division Nephrology and Transplantation, Erasmus MC, Rotterdam, Netherlands, ²Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, MA
*Purpose: Belatacept-based therapy in kidney transplant recipient has been shown to increase long-term renal allograft and patient survival compared with calcineurin inhibitor based therapy, however…
2019 American Transplant Congress
Dosing Requirements Of Astagraf Xl In African American Kidney Transplant Recipients Converted From Twice-daily Tacrolimus (aaaktrs)
J. N. Fleming, M. A. Posadas-Salas, D. J. Taber
Medical University of South Carolina, Charleston, SC
*Purpose: Pharmacokinetics from clinical studies demonstrated similar drug exposure (AUC) and correlation between trough (C0) and AUC between tacrolimus IR and Astagraf XL, which led…
2019 American Transplant Congress
The Molecular Features of Chronic Lung Allograft Dysfunction (CLAD) in Transbronchial and Endobronchial Mucosa Biopsies
M. D. Parkes¹, K. M. Halloran¹, J. Chang², P. F. Halloran and the INTERLUNG study group¹
¹University of Alberta, Edmonton, AB, Canada, ²ATAGC, University of Alberta, Edmonton, AB, Canada
*Purpose: Chronic lung allograft dysfunction (CLAD), the major long-term problem in lung transplantation, requires new strategies for prevention and management. However, CLAD is infrequently diagnosed…
2018 American Transplant Congress
Molecular Phenotypes of Injury and Rejection in Lung Transplant Transbronchial Biopsies
M. Parkes, K. Halloran, K. Famulski, P. Halloran, The INTERLUNG Study Group.
University of Alberta, Edmonton, Canada.
Purpose: Histologic assessment of lung transplant transbronchial biopsies (TBB) is not reproducible and cannot assess antibody-mediated rejection (ABMR). Molecular diagnostics (MMDx) successfully identified rejection in…
2018 American Transplant Congress
Intragraft MicroRNA Transcriptome of Acute Antibody Mediated Rejection of Human Kidney Allografts
H. Yang,¹ K. Akat,² C. Li,¹ C. Snopkowski,¹ Z. Khan,¹ D. Dadhania,¹ T. Tuschl,² M. Suthanthiran,¹ T. Muthukumar.¹
¹Weill Cornell Medicine, New York; ²Rockefeller University, New York.
BackgroundMicroRNAs (miRNA) are master regulators of gene expression and are potential therapeutic targets. Intragraft miRNA transcriptome of acute antibody rejection (AMR) of human kidney allograft…
2018 American Transplant Congress
Molecular Injury and Repair Assessment in Ex Vivo Perfused Swine Heart Transplants
N. Herbers, S. Hatami, P. Dromparis, J. Nagendran, M. Mengel, D. Freed, B. Adam.
University of Alberta, Edmonton, Canada.
Background: Cardiac transplantation is a life-saving intervention for advanced heart failure but it is unfortunately limited by a critical shortage of suitable donor organs and…
2018 American Transplant Congress
T Cell-Mediated Rejection Poses Greater Risk to Graft Survival Than Antibody-Mediated Rejection in Heart Transplants
M. Parkes, K. Famulski, P. Halloran, The INTERHEART Study Group.
University of Alberta, Edmonton, Canada.
Purpose: In kidney transplants, failure post-biopsy is associated with acute injury transcript expression reflecting the histologically silent tissue response-to-wounding (JCI 120:1862) and antibody-mediated rejection (ABMR),…
2018 American Transplant Congress
Peripheral Blood Immune Response-Related Gene Analysis for Evaluating the Development of Subclinical Antibody-Mediated Rejection
T. Yamamoto,¹ K. Iwasaki,² K. Murotani,³ A. Takeda,⁴ M. Tsujita,⁴ T. Hiramitsu,⁴ N. Goto,⁴ S. Narumi,⁴ Y. Watarai,⁴ K. Uchida,² T. Kobayashi.⁵
¹Xenotransplantation, University of Alabama at Birmingham, Birmingham, AL; ²Kidney Disease and Transplant Immunology, Aichi Medical University, Nagakute, Japan; ³Biostatistics, Aichi Medical University, Nagakute, Japan; ⁴Kidney Center, Nagoya Daini Red Cross Hospital, Nagoya, Japan; ⁵Renal Transplant Surgery, Aichi Medical University, Nagakute, Japan.
Background: Noninvasive methods for the early diagnosis of chronic antibody-mediated rejection (cAMR) are desired for patients with de novo (dn) donor-specific HLA antibody (DSA) because…
2018 American Transplant Congress
Histogenomics: Molecular Profiling of Kidney Biopsies Predict Delayed Graft Function
P. Rao,¹ D. Deo,¹ B. Fyfe-Kirschner,² R. Siderits.²
¹NJ Sharing Network, New Providence, NJ; ²Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.
IntroductionHistologic assessments of donor renal biopsies for percentage global glomerulosclerosis, interstitial fibrosis and arterial sclerosis can predict renal graft failure post-transplant.The morphologic evaluation of renal…
2018 American Transplant Congress
Inflammation in Scarred Areas (I-IFTA) is a Reflection of Parenchymal Injury (Response to Wounding) Not T Cell-Mediated Rejection
P. Halloran, J. Chang, K. Famulski.
Medicine, University of Alberta, Edmonton, AB, Canada.
Inflammation in fibrotic renal parenchyma (i-IFTA) is associated with decreased graft survival but by Banff rules is not diagnostic for rejection. Some researchers believe that…