2020 American Transplant Congress
Assessment of the Usefulness of Urine Signature to Differentiate Acute Rejection in a Prospective Kidney Transplantation Cohort
*Purpose: Despite many biomarker studies in the field of transplantation, development and validation of noninvasive molecular assays to diagnose disease and monitor immune activity is…2020 American Transplant Congress
Unexpected Regulation of Foxp3+ Treg Production, Stability and Function by the Nuclear Co-Repressor, Sin3A
*Purpose: Foxp3+ T-regulatory (Treg) cells are crucial to immune homeostasis and self-tolerance, but the contributions to Tregs of the 4 large, multiprotein nuclear complexes (Sin3,…2020 American Transplant Congress
Single Cell RNA Sequencing of Murine Kidney Allografts Identifies Macrophage Gene Signature Associated with Acute Rejection
*Purpose: Evaluating kidney allografts using single cell RNA sequencing (scRNAseq) can provide a comprehensive qualitative and quantitative gene expression data on thousands of individual cells.…2020 American Transplant Congress
Use of tCRM to Aid Diagnosis of Allograft Rejection in Kidney Transplantation
*Purpose: To apply an unbiased, quantitative, molecular profiling score for graft inflammation using standardized assays, in the context of a prospective clinical trial in kidney…2020 American Transplant Congress
Human Antigen R (HuR): A New Regulator of Heme Oxygenase-1 Cytoprotection in Mouse and Human Liver Transplantation
*Purpose: Ischemia-reperfusion injury (IRI) represents a risk factor in liver transplantation (LT). We have shown that overexpression of heme oxygenase 1 (HO-1) mitigates hepatic IRI…2020 American Transplant Congress
Widespread Deregulation of Metabolic Genes in Steatotic Livers Pre- And Post-Transplantation
*Purpose: The escalating obesity crisis is a double-edged sword for the field of liver transplantation; higher rates of fatty liver disease increase both the demand…2020 American Transplant Congress
Antibody-Mediated Rejection with and without Donor-Specific Anti-HLA Antibodies: Performance of the Peripheral Blood 8-Gene Expression Assay
*Purpose: Therapeutic implications of the recently discovered 8-gene expression assay are most clear for detection of antibody-mediated rejection in presence of donor-specific anti-HLA antibodies (HLA-DSA).…2020 American Transplant Congress
RNA Sequencing of Urine RNA Samples for Biomarker Discovery
*Purpose: An accurate, noninvasive assay based on urinary gene expression profiles would be a powerful tool for clinical management of kidney transplant patients. We have…2020 American Transplant Congress
Evolution of Molecular Lung Transplant Biopsy Assessment: Rejection Can be Detected in Mucosal as Well as Transbronchial Biopsies
*Purpose: We recently developed a Molecular Microscope® (MMDx) rejection assessment platform for mucosal biopsies from the third airway bifurcation (3BMB) and transbronchial biopsies (TBB) from…2020 American Transplant Congress
Single-Cell RNA Sequencing Reveals Gene Expression Profiling of Ischemia Reperfusion Injury
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
*Purpose: Ischemia-reperfusion injury (IRI) during liver transplantation is an important factor that leads to graft dysfunction and even recipient death. This study aims to explore…
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