Articles tagged "Gene expression"

2022 American Transplant Congress
LGALS1 is Expressed in Glomerular Endothelial Cells and Induced Upon Stimulation with Anti-HLA Antibody
A. Boshart¹, S. Farkona¹, S. Clotet-Freixas¹, C. McEvoy¹, J. Murphy¹, S. Crome², A. Konvalinka³
¹Toronto General Hospital Research Institute, Ajmera Transplant Centre, University Health Network, Toronto, ON, Canada, ²Immunology, Toronto General Hospital Research Institute, Ajmera Transplant Centre, University of Toronto, University Health Network, Toronto, ON, Canada, ³Nephrology, Toronto General Hospital Research Institute, Ajmera Transplant Centre, University Health Network, Toronto, ON, Canada
*Purpose: Antibody-mediated rejection (AMR) accounts for >50% of premature kidney graft loss. AMR is caused by donor specific antibodies (DSA) against human leukocyte antigens (HLA)…
2022 American Transplant Congress
Gene Profiling to Distinguish Mechanisms of Liver Allograft Rejection and Acceptance in Cynomolgus Monkey
H. Sakai¹, E. Berglund¹, S. Chaudhry¹, Y. Kato¹, E. Duggan¹, J. Weiner¹, P. Alonso-Guallart¹, N. Llore¹, K. Brustle¹, J. Stern¹, B. Piegari¹, D. Ekanayake-Alper¹, M. Martinez², G. Pierre¹, M. Danton¹, S. Kofman¹, D. Ordanes¹, D. Hajosi¹, J. Lefkowitch³, A. Iuga¹, T. Kato⁴, A. Griesemer¹
¹Columbia Center for Translational Immunology, Columbia University, New York, NY, ²Department of Pediatrics, Columbia University, New York, NY, ³Departments of Pathology and Cell Biology, Columbia University, New York, NY, ⁴Department of Surgery, Columbia University, New York, NY
*Purpose: Liver is an immune regulatory organ. Spontaneous resolutions from rejection have been seen in our orthotopic cynomolgus monkey liver transplant models for tolerance induction…
2022 American Transplant Congress
Immune Cell Phenotype of Acute Rejection of Pancreas Allografts by RNA Sequencing Analysis
C. Hughes, H. Yang, C. Snopkowski, C. Li, D. M. Dadhania, S. Sultan, C. Hartono, M. Suthanthiran, S. V. Seshan, T. Muthukumar
Weill Cornell Medicine, New York, NY
*Purpose: Long term survival of pancreas allografts are inferior to kidney allografts. Molecular mechanisms underpinning pancreas allograft rejection and failure have not been explored in…
2022 American Transplant Congress
PCR-Enhanced Performance Characteristics of TruGraf Gene Expression Profile in Kidney Transplant
P. West-Thielke¹, J. Fleming¹, C. Miller¹, N. Grund¹, A. Sutton¹, R. Sinha², M. Miller², S. Kleiboeker², J. Weems³
¹Transplant Genomics, Inc., Framingham, MA, ²Eurofins-Viracor, Lees Summit, MO, ³Transplant Genomics, Inc., Lees Summit, MO
*Purpose: The aim of this study was to perform clinical validation of TruGraf GEP using PCR methodology, as compared to the previously used microarray methodology,…
2022 American Transplant Congress
Gene Expression Changes Including Long Non-Coding RNAs in Human Hepatic Ischemia Reperfusion Injury
C. Kuscu¹, S. Naik¹, C. Eymard², H. Ingram¹, A. Bajwa¹, D. Maluf³, V. Mas⁴, J. Eason⁵, C. Kuscu¹
¹Transplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, ²James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, ³Surgery, University of Maryland, Baltimore, MD, ⁴University of Maryland, Baltimore, MD, ⁵University of Tennessee/Methodist Transplant Institute, Memphis, TN
*Purpose: Ischemia reperfusion injury (IRI) is still one of the major problems in liver transplantation affecting long term outcomes. This study is sought out to…
2022 American Transplant Congress
Single-Cell RNA Sequencing Identifies the Changes of Human Normal Kidney After Transplantation
G. Huang¹, H. Zhang¹, X. Chen¹, G. Zhao¹, J. Luo¹, S. Yang², J. Qiu¹
¹Organ Transplant Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China, ²Department of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China
*Purpose: We found that in all studies about kidney transplantation and single cell RNA sequencing (scRNA-seq), the native kidney rather than the transplanted kidney was…
2022 American Transplant Congress
Kidney Grafts with Poor 24-Month Function Present Upregulated Immune Activity at Pre-Transplantation
E. Bardhi¹, K. Archer², D. Maluf¹, J. McDaniels¹, T. Rousselle¹, E. Akalin³, T. Mueller⁴, V. Mas¹
¹University of Maryland, Baltimore, MD, ²Ohio State University, Columbus, OH, ³Montefiore Medical Center, Bronx, NY, ⁴University Hospital Zürich, Zürich, Switzerland
*Purpose: A transcriptomic profile serves as a snapshot of the temporary cell state and thus, analyzing pretransplant kidney biopsies can provide detailed information on the…
2022 American Transplant Congress
The Role Of Gut Microbiome In Optimum Dose Selection Of Tacrolimus For Kidney Transplant Recipients
M. Nayebpour¹, N. Koizumi¹, J. Melancon²
¹George Mason University, Arlington, VA, ²George Washington University Hospital, Washington, DC
*Purpose: This study aims to validate and apply a personalized optimal dose selection model for Tacrolimus (Tac) for kidney transplant recipients at the George Washington…
2022 American Transplant Congress
Investigating RNA Interference-Mediated Inhibition of Liver Ischemia Reperfusion Injury During Liver Preservation
J. E. Buchwald¹, D. Echeverria², J. Sousa², N. McHugh², A. Khvorova², P. N. Martins³
¹RNA Therapeutics Institute, Department of Surgery, University of Massachusetts Chan Medical School, Worcester, MA, ²RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, ³Department of Surgery, University of Massachusetts Chan Medical School, Worcester, MA
*Purpose: Liver transplantation cures acute end-stage and chronic liver diseases, yet current strategies of organ preservation including static cold storage (SCS) and machine perfusion (MP)…
2022 American Transplant Congress
Gene Expression Profiles of Peritubular Capillarits in Chronic Antibody-Mediated Rejection
M. Eder¹, M. Röbl¹, H. Omic¹, B. Adam², D. Cejka³, N. Kozakowski⁴, D. D´Andrea⁵, M. Mengel², Ž. Kikić⁵
¹Internal Medicine III, Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria, ²Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada, ³Department of Medicine III, Nephrology, Hypertension, Transplantation and Rheumatology, Ordensklinikum Linz – Elisabethinen, Linz, Austria, ⁴Department of Pathology, Medical University of Vienna, Vienna, Austria, ⁵Department of Urology, Medical University of Vienna, Vienna, Austria
*Purpose: Antibody-mediated rejection (ABMR) is one of the most significant contributors to late graft loss. Hallmark characteristics include peritubular capillaritis (ptc) and glomerulitis (g). Diffuse…

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