Articles tagged "FK506"

2016 American Transplant Congress
Influence of the Tacrolimus Metabolism Rate on BKV Infection After Kidney Transplantation.
G. Thölking,¹ C. Schmidt,¹ K. Schuette-Nuetgen,¹ D. Pabst,¹ R. Koch,² H. Wolters,³ S. Reuter,¹ B. Suwelack.¹
¹Department of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Münster, Münster, Germany; ²Institute of Biometrics and Clinical Research, University of Münster, Münster, Germany; ³Department of General Surgery, University Hospital of Münster, Münster, Germany.
Introduction: BK virus (BKV) infection is a serious complication following renal transplantation (RTx). The minimization of risk factors that predict BKV infection might help to…
2016 American Transplant Congress
Comparison of Transplant Outcomes for Low-Dose and Standard-Dose Tacrolimus in Kidney Transplant Recipients.
J.-H. Cho, K. Kim, M. Kim, W. Do, Y. Yang, T. Yim, I. Hwang, J.-H. Lee, E. Kwon, H.-Y. Jung, J.-Y. Choi, S.-H. Park, Y.-L. Kim, C.-D. Kim.
Internal Medicine, Kyungpook National University School of Medicine, Daegu, Republic of Korea.
Objectives: There are few studies that compare the effect of different dose of tacrolimus after kidney transplantation. We investigated transplant outcome of low-dose and standard-dose…
2016 American Transplant Congress
Comparison of Actual versus Goal Tacrolimus Levels Post Cardiothoracic Transplant.
E. Milas, I. Feurer, C. Truscott, J. Gray, N. Wilson, S. Bala, T. Dreher, M. Wigger, M. Steele, A. Shah, E. Lambright, D. Hanto.
Vanderbilt Transplant Center, Nashville, TN.
BackgroundAlthough target tacrolimus (TAC) trough levels necessary to prevent rejection are established post heart/lung transplant (tx), there is little published literature on the proportion of…
2016 American Transplant Congress
Prospective Randomized Controlled Study Evaluating the Relationship Between Electronic Adherence Data and Tacrolimus Concentration Data.
B. Kane,¹ M. Lockwood,¹ L. Potter,¹ L. Lourenco,¹ A. Bodzin,¹ D. Covington,² K. Mayer,³ J. Millis.¹
¹University of Chicago Transplant Center, University of Chicago, Chicago, IL; ²Clinical Research, Innovation Clinical Research, LLC, Tucson, AZ; ³R&D, SIMpill, LLC, Madison, WI.
Purpose: The SIMpill® Medication Adherence System (MAS) is being evaluated in transplant recipients in a prospective 3-year study. The MAS captures patient medication adherence data…
2016 American Transplant Congress
Are Random Tacrolimus Levels in the Emergency Department Costing You Money?
B. Lee, D. Jain, M. Campara.
University of Illinois at Chicago, Chicago.
Purpose: Tacrolimus (TAC) is the most frequently used immunosuppressant in the USA today, with a narrow therapeutic index that requires frequent 12-hour trough monitoring and…
2016 American Transplant Congress
The Effects of Brain Death and Ischemia on Tolerance Induction Are Organ-Specific.
S. Michel,^1,2 M. Madariaga,¹ G. LaMuraglia II,¹ R. Colvin,³ E. Farkash,³ J. Allan,^1,4 D. Sachs,¹ K. Yamada,¹ J. Madsen.^1,5
¹Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ²Department of Cardiac Surgery, Ludwig-Maximilians-University, Munich, Germany; ³Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ⁴Division of Thoracic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ⁵Division of Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Background. We have previously shown that 12 days of high-dose calcineurin inhibition induced tolerance in miniature swine transplanted with MHC mismatched lung or cotransplanted heart…
2016 American Transplant Congress
Pharmacokinetic Evaluation of Astagraf XL® and Prograf® in Renal Transplant Candidates Following Laparoscopic Sleeve Gastrectomy.
A. Lichvar,¹ A. Leino,¹ T. Kaiser,¹ T. Mizuno,² T. Fukuda,² U. Christians,¹ R. Alloway,¹ A. Vinks,² E. Woodle,¹ T. Diwan.¹
¹University of Cincinnati, Cincinnati; ²Cincinnati Children's Hospital, Cincinnati; ³University of Colorado, Denver.
Purpose: The impact of laparoscopic sleeve gastrectomy (LGS) on immunosuppressive drug pharmacokinetics (PK) is unknown. The purpose of this study was to evaluate PK following…
2016 American Transplant Congress
Contrasting Effects of Tacrolimus and Everolimus on Regulatory T Cell Activation and Mixed Hematopoietic Chimerism Induced by Natural Killer T Cell Stimulation.
S. Miyairi,^1,2 T. Hirai,¹ R. IShii,¹ M. Okumi,¹ Y. Ishii,³ S. Nunoda,² K. Yamazaki,² K. Tanabe.¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Cardiovascular Surgery, Tokyo Women's Medical University, Tokyo, Japan; ³Laboratory of Vaccine Design, RIKEN IMS-RCAI, Yokohama, Japan.
Calcineurin (CN)-dependent IL-2 production is crucial for regulatory T cells (Tregs) to demonstrate suppressive activity. The mTOR signal is not required for Treg function because…
2016 American Transplant Congress
Tacrolimus (Tac), Rather Than Cyclosporine (CsA), Interacts with Insulin Resistance (IR) to Alter Key Transcription Factors for β-Cell Identity & Function without Altering NFAT Localization.
J. Triñanes,¹ A. Rodriguez,² E. de Koning,¹ J. de Fijter,¹ F. Carlotti,¹ A. Torres,² A. de Vries,¹ E. Porrini.²
¹Nephrology, Leiden University Medical Center, Leiden, Netherlands; ²CIBICAN, University of La Laguna, Tenerife, Spain.
Inhibiting the calcineurin(CN)/NFAT-pathway in β-cells may contribute to posttransplant diabetes. The presumed higher diabetogenicity of Tac is thought to owe to an IC50 for CN…
2016 American Transplant Congress
Two-Year Safety Results from the Phase 3b Switching Study of Kidney Transplant Patients with Tremor to LCP-Tacro (STRATO) Study.
S. Steinberg,¹ R. Gedaly,² L. Chan,³ A. Langone.⁴
¹California Institute of Renal Research, San Diego; ²University of Kentucky Medical Center, Lexington; ³University of Colorado, Aurora; ⁴Vanderbilt University Medical Center, Nashville.
Tremor is a common side effect of tacrolimus (tac) correlated with peak-dose drug concentration. Envarsus XR®, a novel, once-daily, extended-release formulation of tac, has a…