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Articles tagged "FK506"

  • 2016 American Transplant Congress

    Contrasting Effects of Tacrolimus and Everolimus on Regulatory T Cell Activation and Mixed Hematopoietic Chimerism Induced by Natural Killer T Cell Stimulation.

    S. Miyairi,1,2 T. Hirai,1 R. IShii,1 M. Okumi,1 Y. Ishii,3 S. Nunoda,2 K. Yamazaki,2 K. Tanabe.1

    1Urology, Tokyo Women's Medical University, Tokyo, Japan; 2Cardiovascular Surgery, Tokyo Women's Medical University, Tokyo, Japan; 3Laboratory of Vaccine Design, RIKEN IMS-RCAI, Yokohama, Japan.

    Calcineurin (CN)-dependent IL-2 production is crucial for regulatory T cells (Tregs) to demonstrate suppressive activity. The mTOR signal is not required for Treg function because…
  • 2016 American Transplant Congress

    Tacrolimus (Tac), Rather Than Cyclosporine (CsA), Interacts with Insulin Resistance (IR) to Alter Key Transcription Factors for β-Cell Identity & Function without Altering NFAT Localization.

    J. Triñanes,1 A. Rodriguez,2 E. de Koning,1 J. de Fijter,1 F. Carlotti,1 A. Torres,2 A. de Vries,1 E. Porrini.2

    1Nephrology, Leiden University Medical Center, Leiden, Netherlands; 2CIBICAN, University of La Laguna, Tenerife, Spain.

    Inhibiting the calcineurin(CN)/NFAT-pathway in β-cells may contribute to posttransplant diabetes. The presumed higher diabetogenicity of Tac is thought to owe to an IC50 for CN…
  • 2016 American Transplant Congress

    Two-Year Safety Results from the Phase 3b Switching Study of Kidney Transplant Patients with Tremor to LCP-Tacro (STRATO) Study.

    S. Steinberg,1 R. Gedaly,2 L. Chan,3 A. Langone.4

    1California Institute of Renal Research, San Diego; 2University of Kentucky Medical Center, Lexington; 3University of Colorado, Aurora; 4Vanderbilt University Medical Center, Nashville.

    Tremor is a common side effect of tacrolimus (tac) correlated with peak-dose drug concentration. Envarsus XR®, a novel, once-daily, extended-release formulation of tac, has a…
  • 2016 American Transplant Congress

    CoCl2 Induced ER Stress Protein Mediated Cytotoxicity in FK506 Treated Hepatoma HepG2 Cells.

    S. Choi, S. Chung.

    Surgery, Chonnam National University Hospital, Gwangju, Republic of Korea; Surgery, Chonnam National University Hospital, Gwangju, Republic of Korea.

    Background; The effects of FK506 on the endoplasmic reticulum (ER) mediated stress pathway accelerates CoCl2 - induced cytotoxicity in human hepatoma HepG2 cell line were…
  • 2016 American Transplant Congress

    Conversion to Once-Daily Tacrolimus in Stable Pediatric Liver Transplantation Recipients.

    N. Lee, S. Lee, C.-W. Cho, J. Lee, J. Lee, J. Kim, G.-S. Choi, C. Kwon, J.-W. Joh, S.-K. Lee.

    Department of Surgery Organ Transplant Center, Samsung Medical Center, Seoul, Republic of Korea.

    Purpose: Pediatric patients are known to have lower compliance than adult patients. Once-daily formulation of tacrolimus may increase compliance in pediatric liver transplant recipients. The…
  • 2016 American Transplant Congress

    Mechanism of FK506 Induced TNF Related Apoptosis in Jurkat T Cells.

    S. Chung, S. Choi.

    Department of Surgery, Chonnam National University Hospital, Gwangju, Korea.

    Purpose: To elucidate the mechanism of FK506 induced TRAIL(TNF related apoptosis inducing ligand) –R1(DR4) and TRAIL-R2(DR5) in FK506-treated Jurkat T cells. And signal transduction pathway…
  • 2016 American Transplant Congress

    Nuclear Factor of Activated T-Cells Post-Renal Transplant.

    K. Tornatore,1,4 K. Attwood,2 O. McGuire,3 K. O'Loughlin,3 R. Venuto,4 H. Minderman.3

    1Translational Pharmacology Research Center, School of Pharmacy, Buffalo; 2Biostatistics, School of Public Health, Buffalo; 3Flow Cytometry Laboratory, Roswell Park Cancer Institute, Buffalo; 4Medicine, School of Medicine, University at Buffalo, Buffalo.

    Background: Nuclear Factor of Activated T-cells (NFAT1) is a transcription factor regulating the expression of key targets involved with cellular immune function. Calcineurin is a…
  • 2016 American Transplant Congress

    Can We Predict New-Onset Diabetes After Transplantation Previously?

    R. Imamura,1 K. Tsutahara,2 S. Nakazawa,1 Y. Kakuta,1 T. Abe,1 T. Takao,2 N. Ichimaru,3 S. Yamaguchi,2 S. Takahara,3 N. Nonomura.1

    1Urology, Osaka University Graduate School of Medicine, Suita, Japan; 2Urology, Osaka General Medical Center, Osaka, Japan; 3Advanced Technology for Transplantation, Osaka University Graduate School of Medicine, Suita, Japan.

    Objectives: New-onset diabetes after transplantation (NODAT), one of the important complications after kidneytransplantation, leads to reduce graft survival rate and increase patient morbidity and mortality.…
  • 2016 American Transplant Congress

    Outcomes from De Novo Tacrolimus Weight-Based Dosing Compared to Conservative Dosing in Kidney Transplant Recipients.

    B. Summers,2 K. Szempruch,1 M. Harris,2 A. Quidley,1 C. Haisch,1 A. Maldonado.1

    1Vidant Medical Center/East Carolina University, Greenville, NC; 2Duke University Hospital, Durham, NC.

    Purpose: To compare de novo tacrolimus (TAC) weight based dosing (WDG) and conservative dosing (CDG) on incidence and duration of DGF in adult kidney transplant…
  • 2016 American Transplant Congress

    Comparison of Once-Daily and Twice-Daily Low-Dose Tacrolimus in Living Related Kidney Transplantation – Prospective Trial of Once-Daily vs. Twice-Daily Tac – 5 Years Second Report.

    T. Tsuchiya, H. Ishida, T. Nozaki, H. Shirakawa, T. Shimizu, K. Omoto, M. Okumi, K. Tanabe.

    Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.

    Background; Previously, we reported a comparison of the safety and pharmacokinetics between a prolonged-release formulation of Tacrolimus (Tac-QD) and twice-daily tacrolimus (Tac-BD) in the early…
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