2015 American Transplant Congress
Interleukin-1 Receptor Signaling by Graft Stromal Cells Regulates Donor-Reactive CD8 T Cell Responses to Cardiac Allografts
Allograft reperfusion induces inflammation that directs the infiltration of memory T cells into the allograft and their activation to express functions mediating graft injury. The…2015 American Transplant Congress
Increased Precentage of Circulating CD16+ Monocytes Before Transplantation Are Associated With the Occurence of Acute Rejection
Introduction: Monocytes compose a neglected immune cell type in transplantation despite their contribution to antibody mediated rejection. We aimed to define the phenotypic and functional…2015 American Transplant Congress
Detection of Donor Specific HLA-Ab (DSA) Against Native HLA Molecules Expressed On Donor Cell Surface to Eliminate False Positive DSA in Luminex Single Antigen Beads (LMX-SAB)
Pathology, Stanford University, Palo Alto, CA.
Introduction:The LMX-SAB has been extensively used for DSA virtual crossmatch (VXM) to predict actual crossmatch (AXM). The extreme pH and harsh chemical reaction conditions used…2015 American Transplant Congress
A Novel DSA Flow Cytometer Crossmatch (DSA-FXM) to Eliminate Ambiguous Auto- and Allo-FXM Results
Pathology, Stanford University, Palo Alto, CA.
Introduction:Though usually rejected on theoretical grounds, a positive Auto-FXM could result from either or both auto-reactive non-HLA or HLA-antibodies (Ab). Furthermore, a positive Auto-FXM serum…2015 American Transplant Congress
Novel Flow Cytometry Method for Detecting Complement-Fixing Blood Group IgG Antibody in ABO-Incompatible Renal Transplantation
【Background】We experienced a hyperacute rejection (HAR) in ABO-incompatible renal transplantation (ABO-I RTx) on POD 0. We hypothesized that complement-fixing IgG anti-A/B blood group antibody (anti-A/B…2015 American Transplant Congress
Long-Term Persistence of Innate Lymphoid Cells in the Gut After Intestinal Transplantation
Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY.
Introduction: Little is known about innate lymphoid cell (ILC) populations in the human gut, and the turnover of these cells and their subsets after transplantation…2015 American Transplant Congress
Immune Phenotyping of Peripheral Blood Samples from the CTOT-10 Belatacept Study
The purpose of the CTOT-10 study is to evaluate belatacept as maintenance therapy, while minimizing calcineurin inhibitors and corticosteroids in renal transplantation. We designed mechanistic…2015 American Transplant Congress
Single Cell Phospho-Protein Analysis Demonstrates That Immunosuppressive Drugs Inhibit MAPK and mTOR Signaling Molecules in Primary Monocytes After Transplantation
Nephrology and Transplantation, Dept. of Internal Medicine, Erasmus MC, Rotterdam, Netherlands.
Monocytes have been identified as key players driving rejection processes. It is therefore surprising that there are almost no data available about the impact of…2015 American Transplant Congress
Impact of CXCR4/CXCL12 Blockade on Normal Plasma Cells In Vivo
Receptor/ligand interactions in stromal microenvironments play important roles in the localization, development and survival of normal antibody-secreting plasma cells. The goal of the current study…2015 American Transplant Congress
Alterations in Peripheral Blood B Cell Subpopulations in Kidney Transplant Recipients With DSA
Peripheral blood B cell subpopulations were assessed over time (1, 3, 6, 9, and 12 months) in living donor kidney transplant recipients undergoing thymoglobulin (n…
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