ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Endothelial cells"

  • 2017 American Transplant Congress

    Protective Effects of Bryostatin-1 on Neutrophil Migration in an In Vitro Model of Ischemia Reperfusion Injury: Impact for Therapy.

    F. Becker,1 L. Kebschull,1 T. Castor,3 D. Palmes,2 S. Alexander,2 F. Gavins.2

    1Department for General and Visceral Surgery, University Hospital Münster, Münster, Germany; 2Department of Molecular and Cellular Physiology, Department of Molecular and Cellular Physiology, Shreveport, LA; 3Aphios Corporation, Woburn, MA

    Background: Ischemia-reperfusion injury (IRI) is an inherent component of solid organ transplantation and axiomatically linked to graft damage. In the kidney, IRI results in a…
  • 2017 American Transplant Congress

    Apoptotic Exosome-Like Vesicles Released During Tissue Injury Trigger IL23/IL-17 Autoimmune Axis and Accelerate Rejection.

    M. Dieudé,1,4 J. Turgeon,1,4 A. Karakeussian-Rimbault,1,4 L. Pomerleau,1 A. Robitaille,1 N. Grandvaux,1 É. Boilard,2,4 M.-J. Hébert.1,3,4

    1Research Centre, Centre Hospitalier de l'Université de Montréal, Montreal, Canada; 2CHU de Québec, Québec, Canada; 3Montreal University, Montreal, QC, Canada; 4Canadian National Transplantation Research Program, Edmonton, Canada

    Autoantibodies to apoptotic antigens, such as perlecan/LG3, are present pre-transplantation and contribute to organ rejection. We previously showed that during tissue injury, apoptotic endothelial cells…
  • 2017 American Transplant Congress

    TGF-β1 Induces Transplant Kidney Interstitial Fibrosis Through Endothelial-to-Mesenchymal Transition via TGF-β/Smad and Akt/mTOR/p70S6K Pathways.

    Z. Wang, Z. Han, J. Tao, R. Tan, M. Gu.

    Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

    Background: Chronic allograft dysfunction (CAD) induced by kidney interstitial fibrosis is the main cause of allograft failure in kidney transplantation. Studies suggested that endothelial-to-mesenchymal transition…
  • 2017 American Transplant Congress

    Modification of Human Endothelial Cells by CRISPR/Cas9-Mediated Ablation of Class I and II Major Histocompatibility Complex Antigen Expression.

    J. Merola, C. Anderson, H. Xu, T. Manes, J. Pober.

    Yale School of Medicine, New Haven, CT

    Human endothelial cells (ECs) derived from cord blood progenitors have significant replicative potential and are thus well suited for use in tissue engineering of vascularized…
  • 2017 American Transplant Congress

    Uptake of Extracellular Mitochondria Activates Human Endothelial Cells That Stimulate Alloreactive Effector T Cell Responses.

    T. Brennan,1 F. Feng,1 L. Lin,1 M. Song,1 Q.-J. Li,2 A. Kirk,1,2 H. Xu.1

    1Surgery, Duke University, Durham, NC; 2Immunology, Duke University, Durham, NC

    Introduction: Vascular endothelial cells (VECs), the initial barrier between host immunity and donor allograft tissue, play a critical role in allograft rejection. We investigated the…
  • 2017 American Transplant Congress

    Effects of Anti-HLA Antibodies on Endothelial Expression and Serum Levels of Thrombomodulin in Kidney Recipients.

    S. Beland, O. Desy, P. Valin, S. De Serres.

    Medicine, Universite Laval, Quebec, QC, Canada

    Background: Thrombomodulin (TBM) is an anticoagulant and anti-inflammatory protein expressed on endothelial cells (ECs). Mutations of TBM are seen in thrombotic microangiopathies due to aHUS.…
  • 2016 American Transplant Congress

    The 20S Proteasome, Active within Exosome-Like Vesicles Released by Apoptotic Cells Accelerates Rejection.

    M. Dieudé,1,4,5 C. Bell,2,5 J. Turgeon,1,5 D. Beillevaire,1,4,5 S. Qi,1,5 E. Boilard,3,5 P. Thibault,2,5 M.-J. Hébert.1,4,5

    1Research Centre Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Canada; 2Institute for research in immunology and cancer (IRIC), Montreal, Canada; 3Centre de Recherche du CHU de Québec, Québec, Canada; 4Université de Montréal, Montréal, Canada; 5Canadian National Transplant Research Program, Edmonton, Canada.

    Apoptotic bodies (ApoBodies) and apoptotic exosome-like MV (ApoExo) released by apoptotic endothelial cells in vitro were purified by sequential centrifugation and analysed by electron microscopy…
  • 2016 American Transplant Congress

    Human and Mouse Treg Use Lymphotoxin for Migration Across Lymphatic Endothelium.

    C. Brinkman,1 K. Hippen,2 B. Blazar,2 J. Bromberg.1

    1University of Maryland, Baltimore, MD; 2Univerity of Minnesota, Minneapolis, MN.

    Introduction: Lymphotoxin (LT) directs lymphoid organ structure, and LTβ receptor (LTβR) is involved in leukocyte migration into lymph nodes (LN) and thymocyte migration. We previously…
  • 2016 American Transplant Congress

    Everolimus Abrogates C5a and TGFβ Mediated Perycite-to-Myofibroblast Transition (PMT) Inhibiting Vascular Rarefaction.

    G. Castellano, R. Franzin, A. Stasi, C. Divella, L. Gesualdo.

    Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.

    Microvascular pericytes have detrimental effects on tubulo-interstitial fibrosis via PMT. However, therapeutic strategies that might interfere with this process are currently lacking. We aimed to…
  • 2016 American Transplant Congress

    Detection of Endothelial Cell Specific Molecule-1 According to Allograft Status After Kidney Transplantation.

    J.-W. Seo, S.-Y. Kim, Y.-G. Kim, Y.-H. Jeong, Y.-H. Lee, J.-Y. Moon, T.-W. Lee, C.-G. Ihm, S.-H. Lee.

    Division of Nephrology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.

    To investigate urine ESM-1(endothelial cell specific molecule-1) as well as plasma ESM-1 level from renal allograft recipients, we show whether there is the difference of…
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