ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Endothelial cells"

  • 2017 American Transplant Congress

    Apoptotic Exosome-Like Vesicles Released During Tissue Injury Trigger IL23/IL-17 Autoimmune Axis and Accelerate Rejection.

    M. Dieudé,1,4 J. Turgeon,1,4 A. Karakeussian-Rimbault,1,4 L. Pomerleau,1 A. Robitaille,1 N. Grandvaux,1 É. Boilard,2,4 M.-J. Hébert.1,3,4

    1Research Centre, Centre Hospitalier de l'Université de Montréal, Montreal, Canada; 2CHU de Québec, Québec, Canada; 3Montreal University, Montreal, QC, Canada; 4Canadian National Transplantation Research Program, Edmonton, Canada

    Autoantibodies to apoptotic antigens, such as perlecan/LG3, are present pre-transplantation and contribute to organ rejection. We previously showed that during tissue injury, apoptotic endothelial cells…
  • 2017 American Transplant Congress

    TGF-β1 Induces Transplant Kidney Interstitial Fibrosis Through Endothelial-to-Mesenchymal Transition via TGF-β/Smad and Akt/mTOR/p70S6K Pathways.

    Z. Wang, Z. Han, J. Tao, R. Tan, M. Gu.

    Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

    Background: Chronic allograft dysfunction (CAD) induced by kidney interstitial fibrosis is the main cause of allograft failure in kidney transplantation. Studies suggested that endothelial-to-mesenchymal transition…
  • 2017 American Transplant Congress

    Modification of Human Endothelial Cells by CRISPR/Cas9-Mediated Ablation of Class I and II Major Histocompatibility Complex Antigen Expression.

    J. Merola, C. Anderson, H. Xu, T. Manes, J. Pober.

    Yale School of Medicine, New Haven, CT

    Human endothelial cells (ECs) derived from cord blood progenitors have significant replicative potential and are thus well suited for use in tissue engineering of vascularized…
  • 2017 American Transplant Congress

    Uptake of Extracellular Mitochondria Activates Human Endothelial Cells That Stimulate Alloreactive Effector T Cell Responses.

    T. Brennan,1 F. Feng,1 L. Lin,1 M. Song,1 Q.-J. Li,2 A. Kirk,1,2 H. Xu.1

    1Surgery, Duke University, Durham, NC; 2Immunology, Duke University, Durham, NC

    Introduction: Vascular endothelial cells (VECs), the initial barrier between host immunity and donor allograft tissue, play a critical role in allograft rejection. We investigated the…
  • 2017 American Transplant Congress

    Effects of Anti-HLA Antibodies on Endothelial Expression and Serum Levels of Thrombomodulin in Kidney Recipients.

    S. Beland, O. Desy, P. Valin, S. De Serres.

    Medicine, Universite Laval, Quebec, QC, Canada

    Background: Thrombomodulin (TBM) is an anticoagulant and anti-inflammatory protein expressed on endothelial cells (ECs). Mutations of TBM are seen in thrombotic microangiopathies due to aHUS.…
  • 2017 American Transplant Congress

    Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation.

    M. Manook,1,2 J. Kwun,1 J. Yoon,1 K. Samy,1 A. MacDonlad,1 H. Xu,1 R. Smith,3 S. Sacks,3 A. Dorling,3 N. Mamode,2 S. Knechtle.1

    1Surgery, Duke Transplant Center, Durham, NC; 2Renal and Transplant, Guy's and St Thomas's NHS Foundation Trust, Sondon, United Kingdom; 3MRC Centre for Transplantation, London, United Kingdom

    Introduction:Thrombotic microangiopathy (TMA) is a phenomenon observed in antibody-mediated rejection (AMR) of the kidney transplant, particularly in highly sensitized individuals. Following promising data in a…
  • 2017 American Transplant Congress

    Anti-HLA I Antibody Enhances Endothelial Cell-Induced Polarization of Human Monocytes to M2a/c-Like Macrophages.

    X. Wei, N. Valenzuela, M. Rossetti, E. Reed.

    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA

    HLA antibody (Ab)-mediated rejection (AMR) is often characterized by graft-infiltrating macrophages, which correlate with tissue fibrosis. Recent studies suggest they may mainly represent M2-polarized macrophages.…
  • 2017 American Transplant Congress

    Autophagy Regulates LG3 Maturation and Export in Apoptotic Exosome-Like Vesicles.

    D. Beillevaire,1,2,4 M. Francis,1,2,4 G. Diane,2 B. Éric,3,4 D. Mélanie,1,2,4 H. Marie-Josée.1,2,4

    1CRCHUM, Montréal, Canada; 2Université de Montréal, Montréal, Canada; 3CHUL, Québec, Canada; 4CNTRP, Edmonton, Canada

    Background: Autoantibodies to apoptotic antigens such as LG3 – a C-terminal fragment of perlecan– are present pre-transplantation and contribute to organ rejection in renal transplant…
  • 2017 American Transplant Congress

    Platelets Stimulate Liver Sinusoidal Endothelial Cells to Secrete Interleukin-6 During the Early Phase of Liver Regeneration in Mice.

    J. Meyer,1,2 E. Perroud,2 P. Fontana,3,4 K. Sadoul,5 P. Morel,1,2 C. Gonelle-Gispert,2 L. Bühler.1,2

    1Division of Digestive and Transplantation Surgery, University Hospitals of Geneva, Geneva, Switzerland; 2Unit of Surgical Research, University of Geneva, Geneva, Switzerland; 3Division of Angiology and Haemostasis, University Hospitals of Geneva, Geneva, Switzerland; 4Geneva Platelet Group, University of Geneva, Geneva, Switzerland; 5Institute for Advanced Biosciences, Inserm U1209, Grenoble, France

    Background and aimsPlatelets and liver sinusoidal endothelial cells (LSEC) are known to both independently regulate liver regeneration. Our aim was to investigate the role of…
  • 2017 American Transplant Congress

    Rapamycin Directly Alters Human Endothelial Cell Alloimmunogenicity.

    V. Bendersky,1 H. Xu,2 A. Kirk.2

    1School of Medicine, Duke University, Durham, NC; 2Department of Surgery, Duke University, Durham, NC

    The mTOR inhibitor rapamycin (Rapa) is known to suppress T cell function. However, many of its in vivo effects, particularly its synergistic effects with costimulation…
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