ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Endothelial cells"

  • 2017 American Transplant Congress

    Rapamycin Directly Alters Human Endothelial Cell Alloimmunogenicity.

    V. Bendersky,1 H. Xu,2 A. Kirk.2

    1School of Medicine, Duke University, Durham, NC; 2Department of Surgery, Duke University, Durham, NC

    The mTOR inhibitor rapamycin (Rapa) is known to suppress T cell function. However, many of its in vivo effects, particularly its synergistic effects with costimulation…
  • 2017 American Transplant Congress

    Cytotopic Thrombin Inhibition Prior to Cold Ischaemia Attenuates Microvascular Endothelial Ischaemia-Reperfusion Injury.

    B. Sandhu,1 M. Prendecki,1 J. Crawley,1 N. Galloway-Phillips,1 N. Vallant,1 J. Mason,1 A. Dorling,2 R. Smith,2 C. Pusey,1 V. Papalois.1

    1Imperial College, London, United Kingdom; 2King's College, London, United Kingdom

    Purpose: Microvascular dysfunction post-reperfusion of the ischaemic endothelium manifests as cellular necrosis and enhanced endothelial permeability. Thrombin generation post-reperfusion of the ischaemic endothelium may be…
  • 2017 American Transplant Congress

    Regulation of T Cell Migration by Specifically Targeting Lymphotoxin β Receptor (LTβR)-Mediated Non-Canonical NFkB Signaling.

    W. Piao, Y. Xiong, C. Brinkman, J. Bromberg.

    UMB, Baltimore

    Background:Selective recruitment of regulatory T cells (Treg) to draining lymph nodes is crucial for graft survival, and LTαβ-LTβR signaling is required to direct Treg into…
  • 2017 American Transplant Congress

    CD4 T Cell Migration Across Lymphatic Endothelium Is Enhanced by Sphingosine 1-Phosphate (S1P) and Differentially Regulated by S1P Receptors (S1PR).

    Y. Xiong,1 C. Brinkman,1 K. Hippen,2 B. Blazar,2 J. Bromberg.1

    1UMB, Baltimore; 2UM, Minneapolis

    Introduction: S1PR1 drives T cells to migrate from thymus to blood, and from lymph node (LN) to efferent lymphatics. Whether S1PR1 or other S!PRs regulate…
  • 2017 American Transplant Congress

    TIE'ing Statins to Microvascular Stability and Endothelial Cell Immunogenicity.

    C. Ghosh,1 A. Mak,1 M. McGourty,1 S. Parikh,2 X. Chen,2 S. Goldberg,1 J. Wedel,1 D. Briscoe.1

    1Transplant Research Program, Boston Children's Hospital, Boston, MA; 2Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, MA

    Graft microvascular endothelial cells (EC) represent a critical interface between the recipient and the donor. Stable/quiescent EC support immunoregulation in part via the expression of…
  • 2017 American Transplant Congress

    Lymphotoxin (LT) β Receptor-Mediated Non-Classical NFκB Signaling in Lymphatic Endothelial Eells (LEC) is Required for Homeostatic T Cell Migration.

    W. Piao, C. Brinkman, J. Bromberg.

    UMB, Baltimore

    Background: The selective recruitment of regulatory T cells (Treg) or blockade of memory/effector T cell migration to the graft and draining lymph nodes (dLN) are…
  • 2017 American Transplant Congress

    Bioengineering Human Islets to Form Peri-Islet Vessels from Intraislet Endothelial Cells for Improving Human Islet Function.

    G. Loganathan, S. Narayanan, M. Dhanasekaran, A. Patel, W. Tucker, M. Hughes, S. Williams, A. Balamurugan.

    Clinical Islet Laboratory, Dept. of Surgery, Cardiovascular Innovation Institute, University of Louisville, KY

    Native islets in the pancreas have a rich vascular supply however, the current islet isolation technique completely severs the vasculature to islets. As such, these…
  • 2017 American Transplant Congress

    Optimization of Pancreatic Islet-Like Clusters from hiPSCs for Cell Therapy in Type 1 Diabetes.

    G. Pettinato, P. Kyriazis, M. Thompson, M. Koulmanda, R. Fisher.

    Surgery, Beth Israel Deaconess Medical Center, Boston, MA

    IntroductionTreatment for Type 1 Diabetes (T1D) includes pancreas or islets of Langerhans transplantation. Pancreatic beta-like cells from differentiated human induced pluripotent stem cells (hiPSCs) offer…
  • 2017 American Transplant Congress

    Mycophenolic Acid Needs Ca2+ to Exert Its Anti-inflammatory Action via Shedding of Toll-Like Receptor4 and Tumor Necrosis Factor Receptor 1.

    J. Kim,1 W. Yang,1 C. Baek,1 N. Han,2 S.-K. Park.1

    1Division of Nephrology, Department of Internal Medicine, Asan Medical Center, Seoul, Republic of Korea; 2Asan Institute for Life Science, Seoul, Republic of Korea

    Background Mycophenolic acid (MPA) has been used for many years to prevent transplantation rejection. Recently, it has been investigated for its anti-inflammatory effects. MPA can…
  • 2017 American Transplant Congress

    Role of Protease Activated Receptor 1 and Sphingosine-1-Phospate Receptor 1 in Mice Hepatic Ischemia-Reperfusion Injury for Targeting Cell Signal Pathways of Activated Protein C.

    T. Ito, N. Kuriyama, H. Kato, Y. Iizawa, A. Tanemura, Y. Murata, Y. Azumi, M. Kishiwada, S. Mizuno, M. Usui, H. Sakurai, S. Isaji.

    Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu, Japan

    Introduction: Hepatic ischemia-reperfusion injury (IRI) is a serious comlication during liver surgery. As for therapeutic strategies on hepatic IRI, we previously demonstrated that activated protein…
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