Articles tagged "Endothelial cells"

2018 American Transplant Congress
CD40 Signaling in Proximal Tubules Regulates Fibrosis in Both Hypertension and Chronic Allograft Rejection
V. Bletsos, J. Breidenbach, S. Haller, S. Stepkowski.
University of Toledo College of Medicine and Life Sciences, Toledo, OH.
Background: We explored the role of CD40 signaling in kidney proximal tubule epithelial cells on renal interstitial fibrosis (IF) in two models: hypertension; and chronic…
2018 American Transplant Congress
CD4 T Cells Require Both S1PR1 and S1PR4 for Afferent Lymphatic Migration
Y. Xiong,¹ W. Piao,¹ C. Brinkman,¹ L. Li,¹ J. Kulinski,² A. Olivera,² A. Cartier,³ T. Hla,³ S. Schwab,⁴ K. Hippen,⁵ B. Blazar,⁵ J. Bromberg.¹
¹UMB, MD; ²NIH, MD; ³Boston Children's Hospital, MA; ⁴NYU, NY; ⁵U. Minnesota, MN.
Introduction: Sphingosine 1-phospate (S1P) receptor 1 (S1PR1) drives T cell migration from thymus into blood, and lymph nodes (LN) into efferent lymphatics. Whether S1PR1 and…
2018 American Transplant Congress
Lymphatic Endothelium Requires S1PR2 for T Cell Transendothelial Migration
Y. Xiong,¹ W. Piao,¹ C. Brinkman,¹ L. Li,¹ J. Kulinski,² A. Olivera,² A. Cartier,³ T. Hla,³ S. Schwab,⁴ K. Hippen,⁵ B. Blazar,⁵ J. Bromberg.¹
¹UMB, MD; ²NIH, MD; ³Boston Children's Hospital, MA; ⁴NYU, NY; ⁵U. Minnesota, MN.
Introduction: Sphingosine 1-phosphate (S1P) receptors 1 (S1PR1) and S1PR2 are highly expressed by lymphatic endothelial cells (LEC), while T cells express S1PR1 and S1PR4. S1P…
2018 American Transplant Congress
Lymphotoxin Beta Receptor Modulation in Lymphatic Endothelial Cells Alters Regulatory T Cell Dynamics
V. Saxena, W. Piao, Y. Xiong, L. Li, C. Wagner, J. Bromberg.
U Maryland, Baltimore, MD.
Background:Lymphotoxin beta receptor (LTβR) mediated signaling in lymphatic endothelium cells (LEC) is important for migration of regulatory T cells (Treg) to afferent lymphatic vessels (LV)…
2018 American Transplant Congress
Double Deficiency of Gelatinase-A and Gelatinase-B Does Not Protect against Hepatic Ischemia Reperfusion Injury
S. Duarte, P. Matian, S. Ma, R. Busuttil, A. Coito.
Dumont-UCLA Transplant Center, Los Angeles.
Gelatinases, consisting of gelatinase A (MMP-2; 72 KDa) and gelatinase B (MMP-9; 92KDa), are a subgroup of matrix metalloproteinases (MMPs) with key roles in a…
2018 American Transplant Congress
Endothelial Progenitor Cell-Derived Extracellular Vesicles Inhibit Kidney Ischemia-Reperfusion Injury through the Transfer of Specific microRNA and mRNA Coding for the Complement Inhibitors CD55, CD59, Factor H and for the Transcription Factor NRF2: Relevance for Delayed Kidney Graft Function
V. Cantaluppi,¹ D. Medica,¹ S. Dellepiane,¹ G. Merlotti,¹ A. Airoldi,¹ M. Quaglia,¹ G. Castellano,² L. Gesualdo,² G. Camussi.³
¹Nephrology and Kidney Transplantation Unit, University of Piemonte Orientale (UPO), Novara, Italy; ²Nephrology, Dialysis and Kidney Transplantation Unit, University of Bari, Bari, Italy; ³Department of Medical Sciences, University of Torino, Torino, Italy.
Complement activation and oxidative cell damage are hallmarks of delayed kidney graft function (DGF) due to ischemia-reperfusion injury (IRI). Endothelial progenitor cells (EPC) protect from…
2017 American Transplant Congress
Uptake of Extracellular Mitochondria Activates Human Endothelial Cells That Stimulate Alloreactive Effector T Cell Responses.
T. Brennan,¹ F. Feng,¹ L. Lin,¹ M. Song,¹ Q.-J. Li,² A. Kirk,^1,2 H. Xu.¹
¹Surgery, Duke University, Durham, NC; ²Immunology, Duke University, Durham, NC
Introduction: Vascular endothelial cells (VECs), the initial barrier between host immunity and donor allograft tissue, play a critical role in allograft rejection. We investigated the…
2017 American Transplant Congress
Effects of Anti-HLA Antibodies on Endothelial Expression and Serum Levels of Thrombomodulin in Kidney Recipients.
S. Beland, O. Desy, P. Valin, S. De Serres.
Medicine, Universite Laval, Quebec, QC, Canada
Background: Thrombomodulin (TBM) is an anticoagulant and anti-inflammatory protein expressed on endothelial cells (ECs). Mutations of TBM are seen in thrombotic microangiopathies due to aHUS.…
2017 American Transplant Congress
Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation.
M. Manook,^1,2 J. Kwun,¹ J. Yoon,¹ K. Samy,¹ A. MacDonlad,¹ H. Xu,¹ R. Smith,³ S. Sacks,³ A. Dorling,³ N. Mamode,² S. Knechtle.¹
¹Surgery, Duke Transplant Center, Durham, NC; ²Renal and Transplant, Guy's and St Thomas's NHS Foundation Trust, Sondon, United Kingdom; ³MRC Centre for Transplantation, London, United Kingdom
Introduction:Thrombotic microangiopathy (TMA) is a phenomenon observed in antibody-mediated rejection (AMR) of the kidney transplant, particularly in highly sensitized individuals. Following promising data in a…
2017 American Transplant Congress
Anti-HLA I Antibody Enhances Endothelial Cell-Induced Polarization of Human Monocytes to M2a/c-Like Macrophages.
X. Wei, N. Valenzuela, M. Rossetti, E. Reed.
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA
HLA antibody (Ab)-mediated rejection (AMR) is often characterized by graft-infiltrating macrophages, which correlate with tissue fibrosis. Recent studies suggest they may mainly represent M2-polarized macrophages.…