ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Efficacy"

  • 2022 American Transplant Congress

    Safety and Efficacy of Peri-Vaccination Antimetabolite Hold to Augment Third SARS-CoV-2 Vaccine Dose Response in Lung Transplant Recipients

    S. Frey, J. Ruck, J. Alejo, L. Barker, W. Werbel, R. Avery, D. Segev, P. Shah

    Johns Hopkins University School of Medicine, Baltimore, MD

    *Purpose: Lung transplant recipients (LTRs) are less likely than other solid organ transplant recipients (SOTRs) to develop an antibody response to SARS-CoV-2 vaccination. Mycophenolate has…
  • 2022 American Transplant Congress

    Poor Tolerability of CFTR Modulator Therapy in Lung Transplant Recipients

    C. Doligalski, C. McKinzie, A. Yang, R. Coakley

    UNC Health, Chapel Hill, NC

    *Purpose: Elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) is a highly effective therapy for cystic fibrosis (CF) with potential benefits in lung transplant recipients (LTRs) for extrapulmonary CF manifestations, however…
  • 2022 American Transplant Congress

    Evaluation of Conversion from Immediate Release (IR) Tacrolimus to LCP-Tacrolimus (Envarsus XR®, LCP) in Heart Transplant Recipients

    E. Foster1, A. Iaria1, J. Negrelli2, M. Fine2, M. Yu2, M. Liebo2

    1University of Illinois at Chicago, Chicago, IL, 2Loyola University Medical Center, Maywood, IL

    *Purpose: The purpose of this study was to assess outcomes in heart transplant recipients who were converted from IR tacrolimus to LCPT. Limited data exists…
  • 2022 American Transplant Congress

    Noroviral Diarrhea in Solid Organ Transplant Recipients: Characteristics, Interventions and Outcomes

    S. N. Nair, A. Bhaskaran, A. Chandorkar, L. Fontana, K. Obeid

    University of Minnesota, Minneapolis, MN

    *Purpose: Norovirus may result in significant morbidity in solid organ transplant (SOT) recipients. There is limited evidence for therapeutics beyond supportive care for the management…
  • 2022 American Transplant Congress

    Enhanced Delivery of Nanomedicine to Human Kidney During Ex Vivo Perfusion

    C. Albert1, L. Bracaglia1, A. Koide2, J. R. DiRito1, T. Lysyy1, E. Christopher1, J. Grundler1, J. T. Langford1, D. Haakinson1, J. S. Pober1, W. M. Saltzman1, S. Koide2, G. Tietjen1

    1Yale University, new haven, CT, 2Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY

    *Purpose: An efficient delivery of therapeutic agents to graft endothelial cells (ECs) prior to transplantation could render organs more resistant to injury, improving clinical outcomes…
  • 2021 American Transplant Congress

    Automated Electronic Donor Referrals Have Increased Transplantation

    J. Piano

    Transplant Connect, Santa Monica, CA

    *Purpose: It is well understood and supported by previous studies that costly inefficiencies exist in the current phone-based process by which hospitals refer potential donors…
  • 2021 American Transplant Congress

    Efficacy of MAU868, a Novel BKV Neutralizing Monoclonal Antibody (mAb), for the Treatment of Severe BK Virus Nephropathy (BKVN) After Kidney Transplant

    S. C. Jordan1, N. Ammerman2, M. Toyoda3, K. Lim2, J. R. Abend4, A. Patick5, M. R. Hodges5, A. Vo2, S. J. Kovacs6

    1Comprehensive Transplant Center, Cedars Sinai Medical Ctr, West Hollywood, CA, 2Comprehensive Transplant Center, Cedars Sinai Medical Ctr, Los Angeles, CA, 3Cedars Sinai Medical Ctr, Los Angeles, CA, 4Novartis Institutes for BioMedical Research, Virology Research, Emeryville, CA, 5Amplyx Pharmaceuticals, San Diego, CA, 6Novartis Institutes for BioMedical Research, Translational Medicine, East Hanover, NJ

    *Purpose: BKV reactivation leading to nephropathy and allograft loss in kidney transplant (KT) recipients remains a clinical significant concern. No specific or effective anti-BKV therapies…
  • 2021 American Transplant Congress

    Successful Prophylaxis of Antibody-Mediated Rejection by Downregulation of C5 Expression via RNA Interference in a Rat Kidney Transplant Model

    H. Ishigooka1, S. Motoi2, T. Yamakawa1, C. Matsui2, Y. Suzuki3, R. Ishii1, K. Saiga1, D. Tokita1, T. Imai2, K. Tanabe1

    1Urology, Tokyo Women's Medical University, Tokyo, Japan, 2KAN Research Institute, Inc., Kobe, Japan, 3Tsukuba Research Laboratories, Eisai, Co., Ltd., Ibaraki, Japan

    *Purpose: Antibody-mediated rejection (AMR) is a major contributor towards poor prognosis in kidney transplantation. Circulating donor-specific antibodies (DSAs) cause AMR with complement activation. This study…
  • 2021 American Transplant Congress

    Versatile Strategy to Enhance Nanomedicine Delivery to Graft Endothelial Cells

    C. Albert1, L. G. Bracaglia1, A. Koide2, J. DiRito1, T. Lysyy1, C. Edwards1, J. T. Langford1, D. Haakinson1, S. A. Hosgood3, M. L. Nicholson3, J. S. Pober1, W. M. Saltzman1, S. Kiode2, G. Tietjen1

    1Yale University, new haven, CT, 2Perlmutter Cancer Center, New York University, Langone Medical Center, New York, NY, 3University of Cambridge, Cambridge, United Kingdom

    *Purpose: Efficient delivery of therapeutics to graft endothelial cells (EC) can potentially render organs more resistant to injury, improving clinical outcomes. Specific targeting of polymeric…
  • 2021 American Transplant Congress

    Utilizing Risk Factors to Guide Prevention of Invasive Fungal Infections in Liver Transplant Recipients

    K. Fitton, A. Chan, C. Truax, B. Sirandas, T. Larson, L. Smith, A. Carlson

    University of Utah Health, Salt Lake City, UT

    *Purpose: Invasive fungal infection (IFI) after liver transplant (LT) is associated with significant morbidity and mortality. The optimal antifungal prophylaxis regimen has not been defined.…
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