ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Efficacy"

  • 2022 American Transplant Congress

    Safety and Efficacy at 4 Years in Post-Liver Transplant Patients with Chronic Kidney Disease Receiving Tenofovir Alafenamide (TAF) for HBV Prophylaxis

    E. Gane1, B. George1, D. Ray-Chaudhuri1, T. Mules1, C. D. Holt2, H. Wang2, V. Suri2, A. Gaggar2, A. Osinusi2, J. Flaherty2

    1Auckland City Hospital and University of Auckland, Auckland, New Zealand, 2Gilead Sciences, Inc., Foster City, CA

    *Purpose: Recommended antiviral prophylaxis to prevent recurrent HBV infection after liver transplantation includes tenofovir disoproxil fumarate (TDF). However, given risks of bone/renal toxicity associated with…
  • 2022 American Transplant Congress

    Safety and Efficacy of Sodium Glucose Cotransporter-2 Inhibitors in Solid Organ Transplant Recipients

    L. Selznick, J. Contreras, K. Klein, C. Long, R. Hall, S. Bhayana, H. Sweiss

    University Health, San Antonio, TX

    *Purpose: To determine the safety and efficacy of sodium glucose cotransporter-2 inhibitors (SGLT2i) in solid organ transplant.*Methods: This is a retrospective review of adult kidney,…
  • 2022 American Transplant Congress

    Mhealth Coaching Improves Patient Activation and Nutritional Behaviors in Diverse Renal Transplant Recipients

    M. Pollack1, N. Stauffer2, H. Lee2, I. Satoru2, M. Ellis3, C. Diamantidis3, S. Docherty4, E. T. Chambers5

    1Psychiatry, Duke University, Durham, NC, 2Biostatistics, Duke University, Durham, NC, 3Internal Medicine, Duke University, Durham, NC, 4School of Nursing, Duke University, Durham, NC, 5Pediatrics, Duke University, Durham, NC

    *Purpose: Kidney transplant recipients who are not actively engaged in their care and lack self-management skills have poor transplant outcomes. These suboptimal outcomes are disproportionately…
  • 2022 American Transplant Congress

    Outcomes of Very Small Pediatric Donor Kidneys Utilizing Belatacept-Based Immunosuppression in Adult Recipients

    K. Heinen1, A. Carlson2, A. Chan1, M. M. Eiting1, T. Larson1, B. Sirandas1, C. Truax1, L. Smith1

    1University of Utah Health, Salt Lake City, UT, 2Medical University of South Carolina, Johnston, SC

    *Purpose: Due to the lack of data utilizing belatacept as primary immunosuppression for adult recipients of very small pediatric donor kidneys, this study seeks to…
  • 2022 American Transplant Congress

    Long-Term Effects of Conversion from Calcineurin Inhibitors to Sirolimus for the Recipients with Low Immunological Risk in Renal Allograft

    Q. Wu, J. Chen, D. Cheng, X. Ni, X. Li, K. Xie, W. Jiqiu

    National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University Jinling School of Medicine, Nanjing, China

    *Purpose: To observe the long-term effects and prognosis of conversion from calcineurin inhibitors (CNIs) to sirolimus in biopsy-proven low immunological risk renal transplant recipients (RTRs).*Methods:…
  • 2021 American Transplant Congress

    Outcomes in Standard vs. Extended Use of Thymoglobulin as Induction Therapy in Kidney Transplant Recipients

    N. M. Sifontis1, A. Coleman1, D. Tang1, K. Lau2, S. Karhadkar2, A. DiCarlo2, A. Diamond2

    1Temple University School of Pharmacy, Philadelphia, PA, 2Temple University Health System, Philadelphia, PA

    *Purpose: Thymoglobulin induction along with modern maintenance immunosuppression has been found to have a significant reduction in acute rejection in kidney transplantation. The recommended duration…
  • 2021 American Transplant Congress

    Evaluation of Safety and Efficacy of PCSK9 Inhibitors in Solid Organ Transplant Recipients: Experience at a Large Multi-organ Transplant Center

    A. Ucci1, M. Norris2, J. Trofe-Clark2, T. Fallah2, M. Meck1, R. Samudralwar1, M. V. Genuardi3

    1Hospital of Univ of Pennsylvania, Philadelphia, PA, 2Penn Transplant Institute, Hospital of Univ of Pennsylvania, Philadelphia, PA, 3Cardiovascular Medicine Div, Hospital of Univ of Pennsylvania, Philadelphia, PA

    *Purpose: The aim of the study was to characterize the efficacy and safety of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors in solid organ transplant…
  • 2021 American Transplant Congress

    Automated Electronic Donor Referrals Have Increased Transplantation

    J. Piano

    Transplant Connect, Santa Monica, CA

    *Purpose: It is well understood and supported by previous studies that costly inefficiencies exist in the current phone-based process by which hospitals refer potential donors…
  • 2021 American Transplant Congress

    Efficacy of MAU868, a Novel BKV Neutralizing Monoclonal Antibody (mAb), for the Treatment of Severe BK Virus Nephropathy (BKVN) After Kidney Transplant

    S. C. Jordan1, N. Ammerman2, M. Toyoda3, K. Lim2, J. R. Abend4, A. Patick5, M. R. Hodges5, A. Vo2, S. J. Kovacs6

    1Comprehensive Transplant Center, Cedars Sinai Medical Ctr, West Hollywood, CA, 2Comprehensive Transplant Center, Cedars Sinai Medical Ctr, Los Angeles, CA, 3Cedars Sinai Medical Ctr, Los Angeles, CA, 4Novartis Institutes for BioMedical Research, Virology Research, Emeryville, CA, 5Amplyx Pharmaceuticals, San Diego, CA, 6Novartis Institutes for BioMedical Research, Translational Medicine, East Hanover, NJ

    *Purpose: BKV reactivation leading to nephropathy and allograft loss in kidney transplant (KT) recipients remains a clinical significant concern. No specific or effective anti-BKV therapies…
  • 2021 American Transplant Congress

    Successful Prophylaxis of Antibody-Mediated Rejection by Downregulation of C5 Expression via RNA Interference in a Rat Kidney Transplant Model

    H. Ishigooka1, S. Motoi2, T. Yamakawa1, C. Matsui2, Y. Suzuki3, R. Ishii1, K. Saiga1, D. Tokita1, T. Imai2, K. Tanabe1

    1Urology, Tokyo Women's Medical University, Tokyo, Japan, 2KAN Research Institute, Inc., Kobe, Japan, 3Tsukuba Research Laboratories, Eisai, Co., Ltd., Ibaraki, Japan

    *Purpose: Antibody-mediated rejection (AMR) is a major contributor towards poor prognosis in kidney transplantation. Circulating donor-specific antibodies (DSAs) cause AMR with complement activation. This study…
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