Articles tagged "Efficacy"

2016 American Transplant Congress
Induction with T-cell Depletional Agents Is Safe and Efficacious in the Very Elderly Kidney Transplant Recipients: An Analysis of the OPTN Database.
H. Dave, L. Wolfe, H. Fattah, D. Kumar, A. King, M. Levy, A. Cotterell, A. Sharma, C. Bhati, G. Gupta.
Virginia Commonwealth University, Richmond, VA.
Background: Kidney transplantation is increasingly being offered to the very elderly (Age>70 years) kidney transplant recipients. Previous studies analyzing the effect of induction immunosuppression in…
2016 American Transplant Congress
Evaluation of the Long-Term Outcomes with Everolimus After Calcineurin Inhibitor Withdrawal: 36M Results of the H2304 and PROTECT Extension Studies.
L. Fischer,^1,2 J. Fung,¹ H. Metselaar,¹ G. Kaiser,^1,2 P. Schemmer,² P. Neuhaus,² G. Dong,³ P. Lopez,⁴ P. Bernhardt,⁴ H. Schlitt.²
¹H2304 study group, Hamburg, Germany; ²PROTECT study group, Hamburg, Germany; ³Novartis Pharmaceuticals Corporation, East Hanover, NJ; ⁴Novartis Pharma AG, Basel, Switzerland.
Background: The H2304 and PROTECT studies demonstrated reduced nephrotoxicity with everolimus (EVR)-based calcineurin inhibitor (CNI; cyclosporine: CsA, tacrolimus: TAC)-free regimens at Month (M) 12. Here,…
2016 American Transplant Congress
Reduced CMV Infection Using Single Low-Dose of Rabbit Anti-Thymocyte Globulin in Kidney Transplanted Recipients.
M. Paula, C. Felipe, M. Cristelli, P. Orlandi, L. Viana, G. Basso, P. Carvalho, C. Montenegro, A. Lima, I. Pietrobom, H. Tedesco-Silva, J. Medina-Pestana.
Hospital do Rim - UNIFESP, Sao Paulo, Brazil.
BACKGROUND: Cytomegalovirus (CMV) infection is associated with significant morbidity and mortality after solid organ transplantation and the historic incidence of our institution was 77%. Aiming…
2016 American Transplant Congress
Safety, Efficacy, and Cost Saving Potential of Various Weight-Based Dosing for Thymoglobulin Induction Therapy in Kidney Transplant Recipients.
R. Miller,¹ H. Meadows,¹ S. Strout,¹ T. Veasey,¹ A. Mardis,¹ J. Fleming,¹ C. Mardis,¹ N. Pilch,¹ K. Chavin,² D. Taber.²
¹Department of Pharmacy, Medical University of South Carolina, Charleston, SC; ²Department of Surgery, Medical University of South Carolina, Charleston, SC.
Introduction: There are limited data assessing the appropriate weight to use when dosing Thymoglobulin for induction therapy. The aim of this study is to assess…
2016 American Transplant Congress
A Prospective Randomized, Comparative Trial of High-Dose Mizoribine versus Mycophenolate Mofetil in Combination with Tacrolimus and Basiliximab for Living Donor Renal Transplantation: A Multi-Center Trial.
H. Ishida,¹ K. Tanabe,¹ S. Takahara,² N. Amada,³ K. Takahashi,⁴ H. Toma.⁵
¹Urology, Tokyo Women's Medical University Hospital, Tokyo, Japan; ²Advanced Technology for Transplantation, Osaka University, Osaka, Japan; ³Surgery, JCHO Sendai Hospital, Sendai, Japan; ⁴Niigata Organ Transplant Foundation, Niigata, Japan; ⁵Urology, Toda Chuo Hospital, Toda, Saitama, Japan.
PURPOSE: To compare the clinical outcomes of mizoribine (MZR; 12 mg/kg/day) and mycophenolate mofetil (MMF; 2000 mg/day) in combination with tacrolimus (FK), basiliximab (SIM), and…
2016 American Transplant Congress
Novel Effect of miR-26a:Mdm2:p53 Pathway on Mouse Liver Regeneration.
J. Zhou, W. Ju, X. Yuan, X. Jiao, D. Wang, X. Zhu, X. He.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
BACKGROUND: The deficiency of liver regeneration needs to be addressed in the fields of liver surgery, split liver transplantation and living donor liver transplantation. Researches…
2016 American Transplant Congress
ESM1 Gene Promotes Hepatocyte Proliferation Through NF-κB Signal Pathway.
J. Zhou, W. Ju, X. Jiao, X. Zhu, X. He.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
BACKGROUND: Effective and timely liver regeneration is pivotal in the prevention of fetal small-for-size syndrome after living donor liver transplantation or split liver transplantation. Our…
2016 American Transplant Congress
Chimeric Cell Transplantation for Treatment of Duchenne Muscular Dystrophy: A Preliminary Report.
E. Szilagyi, E. Bryndza Tfaily, J. Cwykiel, M. Siemionow.
Orthopaedic Surgery, University of Illinois at Chicago, Chicago.
Background: Transplant of Chimeric Cells, created via ex vivo fusion of donor and recipient cells, represents a promising cell therapy option in the field of…
2016 American Transplant Congress
Human Epineural Allograft Conduits Supported with Mesenchymal Stem Cells Enhance Peripheral Nerve Regeneration: A Preliminary Report.
M. Siemionow, M. Strojny, W. Malewski, J. Cwykiel, M. Cyran.
Department of Orthopaedics, University of Illinois at Chicago, Chicago, IL.
PURPOSE: Due to the limitations of current surgical methods of long nerve defect repair, new therapeutic approaches are needed to enhance nerve regeneration. Nerve allografts…
2016 American Transplant Congress
Schisandra Sphenanthera Extract Facilitates Anti-Tuberculosis Treatment Post Renal Transplantation Through Increasing Bioavailability of Tacrolimus.
R. Deng,¹ L. Zhang,¹ L. Liu,¹ H. Fu,² J. Li,¹ Q. Fu,¹ C. Wang.¹
¹Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; ²Infectious Medicine Department, Guangzhou Infectious Disease Hospital, Guangzhou, China.
Background: Hepatoprotective agent Schisandra sphenanthera extract (SchE) facilitates rifampicin-containing anti-tuberculosis (TB) chemotherapy by stabilizing the Tacrolimus (FK506) blood concentration through increasing the oral bioavailability, which…