Articles tagged "Donors, marginal"

2020 American Transplant Congress
DCD vs DBD Liver Transplantation: Equivalent Charges and Similar Survival- An Effective Expansion of the Donor Pool
N. Singh, K. Helfrich, M. Alebrahim, C. Akateh, K. Mumtaz, A. Logan, A. Schenk, S. Black, E. Elkhammas, K. Washburn, A. El-Hinnawi
Ohio State University, Columbus, OH
*Purpose: The shortage of allografts available for liver transplantation (LT) has prompted the need for expansion of donor pool to include donation after circulatory death…
2020 American Transplant Congress
End-Hypothermic Oxygenated Machine Perfusion after Static Cold Storage versus Static Cold Storage Alone in Kidneys from Extended Criteria Brain-Dead Donors: An International Randomized Controlled Trial
P. Husen¹, C. Boffa², I. Jochmans³, C. Krikke⁴, L. Davies², H. Hofker⁴, J. Pirenne³, R. Ploeg², A. Paul¹
¹General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany, ²Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ³University Hospitals Leuven, Leuven, Belgium, ⁴University Medical Center Groningen, Groningen, Netherlands
*Purpose: A prospective, randomized, single-blinded, multicenter trial comparing the effect of short-term 'in house' oxygenated hypothermic machine preservation (End-HMPO2) following static cold storage (SCS) versus…
2020 American Transplant Congress
Normothermic Machine Perfusion of Extended Criteria Donor Livers: Identification of Protein Biomarkers Predictive of Graft Viability and Post-Transplant Complications
L. L. Wallace¹, J. Attard¹, Y. Boteon¹, R. Laing¹, J. Yu², T. Perera³, D. Mirza³, H. Mergental³, S. Afford¹
¹Centre for Liver and Gastrointestinal Research, University of Birmingham and the NIHR Biomedical Research Centre, UHB NHS Foundation Trust, Birmingham, United Kingdom, ²School of Biosciences, Advanced Mass Spectrometry Facility, University of Birmingham, Birmingham, United Kingdom, ³Liver Unit, The Queen Elizabeth Hospital, Birmingham, United Kingdom
*Purpose: The Viability Testing and Transplantation of mArginal donor Livers Clinical Trial (VITTAL) demonstrated the capacity of Normothermic Machine Perfusion (NMP) to increase the proportion…
2020 American Transplant Congress
KDPI-Based Kidney Discard Risk Assessment
S. Mehrotra¹, M. Barah², K. Bui³
¹IEMS Department, MEAS, Northwestern University, Evanston, IL, ²IEMS Department, Northwestern University, Evanston, IL, ³Department of Mathematics, University of California, Irvine, Irvine, CA
*Purpose: Despite the vital need, 3,553 (19%) deceased-donor kidneys were discarded in 2018 in the current US allocation system. The discard rate has remained at…
2020 American Transplant Congress
From Marginal to Meaningful: Donor Liver Biopsy Increases Donation Rates amongst Elderly Donors
J. A. Steggerda¹, M. B. Bloom¹, K. Mahendraraj¹, G. Voidonikolas¹, T. Todo¹, M. Noureddin², N. N. Nissen¹, A. S. Klein¹, I. K. Kim¹
¹Surgery, Cedars-Sinai Medical Center, Los Angeles, Los Angeles, CA, ²Hepatology, Cedars-Sinai Medical Center, Los Angeles, Los Angeles, CA
*Purpose: Recently, there has been public scrutiny on the non-utilization of elderly donors in liver transplantation. Here, we evaluate the influence of donor liver biopsy…
2020 American Transplant Congress
Severity of Donor Acute Kidney Injury Does Not Impact Long-Term Outcomes in Deceased Donor Renal Transplant Recipients
A. Brar¹, A. Gruessner², D. Adey¹, M. Salifu²
¹University of California, San Francisco, San Francisco, CA, ²SUNY Downstate Medical Center, Brooklyn, NY
*Purpose: Kidneys with increased donor terminal creatinine are frequently discarded. This study used national data to assess renal allograft and patient outcomes in deceased donor…
2020 American Transplant Congress
Impact of Donor Noninvasive Liver Fibrotic Score on Graft Injury in Liver Transplantation
S. M. Younan, T. Ito, H. Hirao, A. Aziz, A. E. Murray, J. DiNorcia III, V. G. Agopian, D. G. Farmer, R. W. Busuttil, F. M. Kaldas
The Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: The increasing prevalence of obesity and metabolic syndrome, has led to a corresponding increase in steatotic livers being utilized in liver transplantation (LT). These…
2020 American Transplant Congress
Significant Improvement in Short and Long-Term Kidney Transplant Survival Despite Stagnant Rates of Delayed Graft Function
J. Schold¹, S. Arrigain², E. Poggio³
¹Cleveland Clinic Foundation, Cleveland, OH, ²Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, OH, ³Nephrology, Cleveland Clinic Foundation, Cleveland, OH
*Purpose: Delayed Graft Function (DGF) is routinely characterized as attributing to significant morbidity and mortality among kidney transplant recipients. While there are diverse potential mechanisms…
2020 American Transplant Congress
Would You Rather Receive a High KDPI SCD Kidney or a Lower KDPI ECD Kidney?
V. Gurram, D. Harriman, A. Farney, J. Rogers, G. Orlando, A. Reeves-Daniel, A. Mena-Gutierrez, C. Jay, R. Stratta
Abdominal Transplant Surgery, Wake Forest Baptist Health, Winston Salem, NC
*Purpose: The study purpose was to review our kidney transplant (KT) experience with emphasis placed on outcomes in patients receiving kidneys that were “discordant” within…
2020 American Transplant Congress
The New UK National Kidney Allocation Scheme with Maximized ‘D4/R4’ Kidney Transplants: Appropriate Donor to Recipient Matching or System Overstretch?
R. Pearson, E. Murray, P. Thompson, P. Mark, M. Clancy, J. Asher
Renal Transplant, Queen Elizabeth University Hospital, Glasgow, Glasgow, United Kingdom
*Purpose: The UK national deceased donor kidney matching scheme changed in September 2019, aiming to better match graft and patient survival. Donors and recipients are…