Session Time: 3:15pm-4:45pm
Presentation Time: 4:15pm-4:27pm
*Purpose: A prospective, randomized, single-blinded, multicenter trial comparing the effect of short-term ‘in house’ oxygenated hypothermic machine preservation (End-HMPO2) following static cold storage (SCS) versus SCS alone on clinical outcome in expanded criteria donor (ECD) kidneys from brain-dead donors (DBD).
*Methods: In a non-paired design, kidneys from ECD donors were assigned to either SCS alone or SCS followed by End-HMPO2 in the recipient center prior to implantation. Minimum machine preservation time was 120min. Primary endpoint was 1-year graft survival, with delayed graft function, primary non-function, acute rejection, eGFR, as well as patient survival as secondary endpoints.
*Results: Centers in Belgium, Germany, Hungary, the Netherlands and the UK randomized 305 kidneys [median donor age 64y (range 50-84)], of which 262 kidneys (127 End-HMPO2, 135 SCS) were successfully transplanted [median recipient age 63y (22-81.2)]. Median cold ischaemia time was 13.2h (range 5.1-28.7) in the End-HMPO2 group and 12.9h (4-29.2) in the SCS group; median duration of End-HMPO2 was 4.7h (0.8-17.1). One year graft survival was 92.1% (N=117) in the End-HMPO2 group vs. 93.3% (N=126) in the SCS group (95% CI: -7.5-5.1, p=0.7). The secondary endpoint analysis showed similar results in both Groups.
*Conclusions: Reconditioning of ECD kidneys from DBD donors using ‘short-term‘ oxygenated hypothermic machine perfusion prior to transplantation after a period of static cold storage does not lead to improved graft survival or function when compared to simple static cold storage alone.
To cite this abstract in AMA style:Husen P, Boffa C, Jochmans I, Krikke C, Davies L, Hofker H, Pirenne J, Ploeg R, Paul A. End-Hypothermic Oxygenated Machine Perfusion after Static Cold Storage versus Static Cold Storage Alone in Kidneys from Extended Criteria Brain-Dead Donors: An International Randomized Controlled Trial [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/end-hypothermic-oxygenated-machine-perfusion-after-static-cold-storage-versus-static-cold-storage-alone-in-kidneys-from-extended-criteria-brain-dead-donors-an-international-randomized-controlled-tria/. Accessed September 30, 2020.
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