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Severity of Donor Acute Kidney Injury Does Not Impact Long-Term Outcomes in Deceased Donor Renal Transplant Recipients

A. Brar1, A. Gruessner2, D. Adey1, M. Salifu2

1University of California, San Francisco, San Francisco, CA, 2SUNY Downstate Medical Center, Brooklyn, NY

Meeting: 2020 American Transplant Congress

Abstract number: C-027

Keywords: Donors, marginal, Graft survival, Kidney, Outcome

Session Information

Date: Saturday, May 30, 2020

Session Name: Poster Session C: Kidney Deceased Donor Selection

Session Time: 3:15pm-4:00pm

 Presentation Time: 3:30pm-4:00pm

Location: Virtual

Related Abstracts
  • Impact of Severity of Glomerulosclerosis on Long-Term Outcomes in Deceased Donor Renal Transplant Recipients with Donor Acute Kidney Injury
  • Impact of Kidney Donor Profile Index (KDPI) on Long-Term Outcomes in Deceased Donor Renal Transplant Recipients with Donor Acute Kidney Injury

*Purpose: Kidneys with increased donor terminal creatinine are frequently discarded. This study used national data to assess renal allograft and patient outcomes in deceased donor renal transplants stratified by severity of donor acute kidney injury (AKI).

*Methods: All adult primary solitary kidney deceased donor transplants performed between 2008 and 2018 reported to the UNOS/OPTN database were analyzed. Groups were further stratified based on terminal donor serum creatinine into 4 groups. Group 1: Serum creatinine<1.5 mg /dl, group 2: 1.5- 1.9 mg/dl, group 3: 2-3.9 mg/dl and group 4 :>= 4 mg/dl .Renal allograft survival and patient survival rates were computed according to Kaplan-Meier and Cox proportional hazards were used to estimate the impact of potential influential variables.

*Results: In this cohort, the number of kidneys transplanted with terminal donor serum creatinine <1.5 mg/dl were 66,589 (78.6%),creatinine 1.5-1.9 mg /dl were 8513(10%),creatinine 2-3.9 mg/dl were 7308 (8.6%) and creatinine 4 mg/dl or greater were 2250(2.6%) respectively.Kidneys transplanted with higher donor serum creatinine increased over time as shown in Table 1. Rates of delayed graft function in the 4 groups were 24.6%, 31.3%, 41.7% and 62.7% respectively. One, three- and five-year renal allograft survival were comparable in the four groups, (93.5%. 85.3%, 75.4%) for donor terminal creatinine < 1.5 mg /dl, (92.3%,84.1%, 73.6%) for donor creatinine 1.5-1.9 mg/dl group, (93.1%,85.8%,75.4%) for donor creatinine 2-3.9 mg/dl and (94.0%, 87.5% ,79.3%) for donor creatinine >4 mg /dl. Patient survival was comparable in all AKI groups as well.

*Conclusions: Use of kidneys from donors with AKI does not adversely affect long term post-transplant outcomes. Careful selection and use of these kidneys will reduce discard rate and optimize organ utilization.

Table 1: Number of deceased donor renal transplants stratified by donor serum creatinine over time.
Donor
Creatinine
2009-2010 2011-2012 2013-2014 2015-2016 2017-2018
<1.5 mg /dl
11970
(80.9%)
12381 (80.2%) 12759 (79.4%)
13777
(77.9%)
15702
(75.8%)
1.5-1.9 mg/dl 1566 (10.6%) 1594 (10.3%) 1673 (10.4%) 1703 (9.6%)
1977
(9.5%)
2-3.9 mg/dl 1082 (7.3%) 1207 (7.8%) 1259 (7.8%) 1622 (9.2%) 2138 (10.3%)
>=4
mg/dl
171 (1.1%) 256 (1.6%) 366 (2.3%) 573 (3.2%) 884 (4.3%)

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To cite this abstract in AMA style:

Brar A, Gruessner A, Adey D, Salifu M. Severity of Donor Acute Kidney Injury Does Not Impact Long-Term Outcomes in Deceased Donor Renal Transplant Recipients [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/severity-of-donor-acute-kidney-injury-does-not-impact-long-term-outcomes-in-deceased-donor-renal-transplant-recipients/. Accessed March 3, 2021.

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