ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Cytomeglovirus"

  • 2016 American Transplant Congress

    Reduced CMV Infection Using Single Low-Dose of Rabbit Anti-Thymocyte Globulin in Kidney Transplanted Recipients.

    M. Paula, C. Felipe, M. Cristelli, P. Orlandi, L. Viana, G. Basso, P. Carvalho, C. Montenegro, A. Lima, I. Pietrobom, H. Tedesco-Silva, J. Medina-Pestana.

    Hospital do Rim - UNIFESP, Sao Paulo, Brazil.

    BACKGROUND: Cytomegalovirus (CMV) infection is associated with significant morbidity and mortality after solid organ transplantation and the historic incidence of our institution was 77%. Aiming…
  • 2016 American Transplant Congress

    Impact of Everolimus and Low-Dose Ciclosporin on Cytomegalovirus Replication and Disease in Pediatric Renal Transplantation.

    B. Höcker,1 S. Zencke,1 L. Pape,2 K. Krupka,1 L. Kösters,1 A. Fichtner,1 L. Dello Strologo,2 I. Guzzo,2 R. Topaloglu,2 B. Kranz,2 J. König,2 M. Bald,2 N. Webb,2 A. Noyan,2 H. Dursun,2 S. Marks,2 Z. Ozcakar,2 F. Thiel,2 H. Billing,2 M. Pohl,2 H. Fehrenbach,2 P. Schnitzler,1 T. Bruckner,1 L. Weber,2 R. Feneberg,2 T. Ahlenstiehl-Grunow,2 B. Tönshoff.1

    1University Children's Hospital, Heidelberg, Germany; 2Certain Research Community, Germany, Italy, Turkey, United Kingdom.

    Purpose: Preclinical studies indicate an anti-cytomegalovirus (CMV) activity of the mammalian target of rapamycin inhibitor (mTORi) everolimus (EVR), but data in pediatric renal transplant recipients…
  • 2016 American Transplant Congress

    NK-Activating MCMV Strain Is Associated with Increased Murine Renal Transplant Injury.

    M. Shimamura,1 M. Li,2 B. Chen,2 J. George,2 T. Schoeb.3

    1Vaccines and Immunity, Pediatric Infectious Diseases, Nationwide Children's Hospital, The Ohio State University, Columbus, OH; 2Pediatric Infectious Diseases, Cardiothoracic Surgery, Nephrology, University of Alabama at Birmingham, Birmingham, AL; 3Pathology and Genetics, University of Alabama at Birmingham, Birmingham, AL.

    Background: CMV contributes to inferior longterm kidney transplant survival. In a murine model, NK cells infiltrate MCMV infected renal allografts in greater numbers than in…
  • 2016 American Transplant Congress

    Reduced Incidence of Cytomegalovirus Infection in Kidney Transplant Recipients Receiving Everolimus: A Cost-Effectiveness Analyses.

    H. Tedesco-Silva, C. Felipe, A. Brigido, M. Cristelli, M. Paula, A. Bessa, P. Ruppel, J. Medina-Pestana.

    Nephrology Division, Hospital do Rim - UNIFESP, Sao Paulo, Brazil.

    A cost-effectiveness analysis was performed using data from a prospective single center trial where de novo kidney transplant recipients received a single 3 mg/kg dose…
  • 2016 American Transplant Congress

    Experience of Short-Term Preemptive Treatment for Cytomegalovirus Infection in Seropositive Patients After Liver Transplantation – Ten Years Result of a Single Institution.

    T.-J. Wu, Y.-C. Wang, C.-H. Cheng, T.-H. Wu, R.-S. Soong, C.-F. Lee, H.-S. Chou, K.-M. Chan, W.-C. Lee.

    Division of Liver and Transplantation Surgery, Department of General Surgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.

    Background/purpose Cytomegalovirus (CMV) infection remains a challenge following liver transplantation. Preemptive treatment is an effective strategy for CMV infection. This report shares the ten years'…
  • 2016 American Transplant Congress

    Infectious Complication in Extremely Elderly Kidney Transplant (KT) Recipients: A Leading Cause of Death.

    J. Cabrera,1,3 M. Fernández-Ruiz,2 M. Molina,1 E. González,1 N. Polanco,1 F. López-Medrano,2 J. Aguado,2 M. Praga,1 A. Andrés.1

    1Department of Nephrology, Hospital Universitario “12 de Octubre”, Madrid, Spain; 2Unit of Infectious Diseases, Hospital Universitario “12 de Octubre”, Madrid, Spain; 3Department of Nephrology, Hospital Evangelico, Montevideo, Uruguay.

    Introduction: The incidence of infection after KT have been reported to directly increase with recipient's age, likely due to the combined effect of co-morbidities and…
  • 2016 American Transplant Congress

    Kinetics of Cytomegalovirus Load in Kidney Transplant Recipients Receiving Everolimus or Mycophenolate Sodium and No Pharmacological Prophylaxis.

    G. Basso, C. Felipe, A. Ferreira, M. Cristelli, N. Oliveira, T. Sandes-Freitas, J. Mansur, L. Viana, W. Aguiar, E. Campos, M. Gerbasi-DeLima, H. Tedesco-Silva, J. Medina-Pestana.

    Hospital do Rim, São Paulo, Brazil.

    The purpose of this analysis is to investigate the kinetics of cytomegalovirus (CMV) viral load in kidney transplant recipients receiving tacrolimus (TAC) plus everolimus (EVR)…
  • 2016 American Transplant Congress

    Standard Dose Valganciclovir Prophylaxis for High-Risk Kidney Transplant Recipients Reduces Incidences of Breakthrough and Resistant Cytomegalovirus Infection.

    Y. Huang, J. Park, A. Naik, D. Kaul.

    University of Michigan, Ann Arbor, MI.

    Background: Valganciclovir (VGCV) 900 mg/day is the standard dose (SD) for CMV prophylaxis in patients with CrCl > 60 ml/min, although some transplant centers use…
  • 2016 American Transplant Congress

    Prospective Randomized OPEN Trial Designed to Reduce the Incidence of Cytomegalovirus (CMV) Infection in DE NOVO Kidney Transplant Recipients Two-Year Results.

    R. Esmeraldo, M. Oliveira, P. Pinheiro, C. Girao, T. Freitas.

    Transplant, Hospital Geral de Fortaleza, Fortaleza, CE, Brazil.

    Introduction: CMV infection is a frequent complication following organ transplantation, and is associated with inferior long-term patient and graft survival. Here we report the results…
  • 2016 American Transplant Congress

    Initial Evaluation of Use of NAT in Assignment of CMV and EBV Infection Status in Children Awaiting Solid Organ Transplant.

    C. Burton, Y. Tong, J. Preiksaitis.

    Medicine, University of Alberta, Edmonton, Canada.

    Purpose: The presence of passive antibodies, transfusion-acquired or maternal in infants, can make serologic determination of pre-transplant CMV and EBV status in children unreliable. We…
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