ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Calcineurin"

  • 2019 American Transplant Congress

    The Impact of Early Subtherapeutic Tacrolimus Troughs with Alemtuzumab Induction

    L. Bowman1, E. Yanqui1, C. Truong1, R. Baliga2, A. Brueckner1

    1Tampa General Hospital, Tampa, FL, 2Florida Kidney Physicians, Tampa, FL

    *Purpose: Prior studies in kidney transplant recipients (KTR) have demonstrated that lower tacrolimus (TAC) exposure during the first week is associated with an increased incidence…
  • 2019 American Transplant Congress

    Long Term Renal Function Following Islet Transplantation in the Clinical Islet Transplantation Consortium

    L. G. Hunsicker1, T. L. Eggerman2, M. R. Rickels3, t. Clinical Islet Transplantation (CIT) Consortium4

    1Internal Medicine, U. Iowa, Iowa City, IA, 2NIDDK/NIH, Bethesda, MD, 3Internal Medicine, U. Pennsylvania, Philadelphia, PA, 4Internal Medicine, University of Iowa, Iowa City, IA

    *Purpose: Islet transplantation (IsletTp) is safe and effective treatment of Type 1 diabetes complicated by severe hypoglycemia (Diabetes Care 2016, 39:1230). But the requirement for…
  • 2019 American Transplant Congress

    Alterations in Cerebral Blood Flow before and after Kidney Transplantation

    A. Gupta1, I. Choi2, R. Lepping3, P. Adany4, A. Jurgensen1, J. Klein1, D. Cibrik1, J. Burns5, W. Brooks2, P. Lee2

    1Division of Nephrology, The Kidney Institute, University of Kansas Medical Center, Kansas City, KS, 2Hoglund Brain Imaging Center, Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, 3Hoglund Brain Imaging Center, Alzheimer’s Disease Center,, University of Kansas Medical Center, Kansas City, KS, 4Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, 5Alzheimer’s Disease Center, Department of Neurology, University of Kansas Medical Center, Kansas City, KS

    *Purpose: End stage renal disease (ESRD) is associated with alterations in cerebral blood flow (CBF) likely secondary to disrupted cerebral autoregulation. In this study we…
  • 2019 American Transplant Congress

    Dual Treatment of CD40 Silencing or Mesenchymal Stem Cells Infusion with Sub-Therapeutic Doses of Cyclosporine Effectively Prevents Acute Rejection in an Allogenic Model of Renal Transplantation

    J. Guiteras1, L. De Ramon1, N. Bolaños1, M. Franquesa2, M. Gomà3, J. Cruzado4, N. Lloberas1, J. Grinyó4, J. Torras4

    1IDIBELL, Hospitalet de Llobregat, Spain, 2IGTP, Badalona, Spain, 3Bellvitge Hospital, Hospitalet de Llobregat, Spain, 4Bellvitge Hospital / IDIBELL, Hospitalet de Llobregat, Spain

    *Purpose: This study was designed to investigate the combination of CD40 silencing or MSC infusion with suboptimal doses of Cyclosporine in this renal allograft model.*Methods:…
  • 2019 American Transplant Congress

    Successful Kidney Transplant Improves Glucose Tolerance – A Paradoxical Report From A Single Center

    A. Mitsuke, H. Harada, H. Higuchi, N. Fukuzawa, H. Tanaka, T. Hirano, T. Sekii

    Kidney Transplantation Surgery, Sapporo City General Hospital, Sapporo, Japan

    *Purpose: Kidney recipients tend to impair glucose tolerance because of several factors such as post-operative obesity, and chronic exposure of some diabetogenic immunosuppressants like calcineurin…
  • 2019 American Transplant Congress

    Microfluidic Study Analyzing the Effect of Immediate-Release and Extended-Release Tacrolimus on Islet Function

    P. West-Thielke1, J. Oberholzer2, Y. Wang3

    1University of Illinois, Chicago, IL, 2University of Virgina, Charlottesville, VA, 3University of Virginia, Charlottesville, VA

    *Purpose: The purpose of this analysis was to quantify the impact of 2 tacrolimus pharmacokinetic profiles on functional changes within human islet cells using a…
  • 2019 American Transplant Congress

    Natural Course Of Tacrolimus Intra-patient Variability In Liver Transplant Recipients

    N. Wilson, S. Tremblay, N. S. Ejaz, K. Zheng, J. Garrett, S. A. Shah, R. R. Alloway, T. E. Kaiser

    University of Cincinnati, Cincinnati, OH

    *Purpose: The evolution of tacrolimus (TAC) intra-patient variability (IPV) post liver transplant (LT) remains to be characterized. Identification of factors associated with high TAC-IPV may…
  • 2019 American Transplant Congress

    Transcriptome Profiling Of Renal Transplant Biopsies With Acute Cellular Rejection From Patients On Calcineurin Inhibitor-based Or Cni-avoidance Immunosuppression

    D. Dobi1, F. Vincenti2, Z. G. Laszik1

    1Department of Pathology, University of California, San Francisco, San Francisco, CA, 2Departments of Medicine and Surgery, University of California, San Francisco, San Francisco, CA

    *Purpose: Despite their suboptimal toxicity profile, calcineurin-inhibitors (CNIs) remain the cornerstone of renal transplant immunosuppression. Previous efforts to completely eliminate CNIs failed, because CNI-avoidance protocols…
  • 2019 American Transplant Congress

    Gut Microbiota May Affect a Variability of Tacrolimus Trough Levels in Kidney Transplant Recipients

    J. Kim1, H. Cho2, J. Park3, M. Kwak4, B. Kim4, J. Lee5, D. Kim1, B. Kim6, Y. Kim1, H. Lee1

    1Seoul National University Hospital, Seoul, Korea, Republic of, 2Chungbuk National University Hospital, Cheongju, Korea, Republic of, 3Kangwon National University Hospital, Chuncheon, Korea, Republic of, 4Chunlab Inc., Seoul, Korea, Republic of, 5Seoul National University Boramae Hospital, Seoul, Korea, Republic of, 6Hallym University, Chuncheon, Korea, Republic of

    *Purpose: The gut microbiota alters expression of drug-metabolizing enzymes and transporters, and consequently affects therapeutic dose and response of medicines. We aimed to investigate the…
  • 2019 American Transplant Congress

    The Impact of Calcineurin Inhibitors on De Novo DSA in Primary Kidney Transplantation

    T. Hiramitsu, T. Tomosugi, K. Futamura, M. Okada, M. Tsujita, T. Ichimori, N. Goto, S. Narumi, Y. Watarai

    Nagoya Daini Red Cross Hospital, Nagoya Aichi, Japan

    *Purpose: De novo DSA was demonstrated as a cause of chronic AMR, leading to worse graft survival. New strategies to treat chronic AMR have been…
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