2019 American Transplant Congress
Nephrotoxicity Caused by Calcineurin Inhibitors is Meditated by BAX, NOL3 and XIAP Apoptotic Genes Dysregulation
*Purpose: Calcineurin inhibitors (CNI) remain the most effective and widely used immunosuppressive agents in kidney transplantation. Nephrotoxicity is a major secondary effect, and renal biopsy…2019 American Transplant Congress
How and Why Dyrk1a is Required for Optimal Foxp3+ Treg Functions
Children's Hospital of Philadelphia, Philadelphia, PA
*Purpose: TCR-induced calcineurin phosphatase activation and subsequent Nfat dephosphorylation, leading to Nfat translocation to the nucleus, is a key event in conventional T cell activation.…2019 American Transplant Congress
Cardioprotective Effects of Pre-Operative Cyclosporine in Patients Undergoing Heart Transplantation
Duke University Hospital, Durham, NC
*Purpose: The purpose of this study is to determine if pre-operative cyclosporine (Cya) decreases the rate of primary graft dysfunction (PGD) in patients undergoing orthotopic…2019 American Transplant Congress
Mitochondrial Dysfunction and Metabolic Reprogramming: Critical Features of Cyclosporine A Nephrotoxicity
University of Alabama at Birmingham, Birmingham, AL
*Purpose: Calcineurin inhibitors (CNIs) are potent immunosuppressants but over time contribute to allograft fibrosis. Clinical efforts to minimize or avoid CNI have not been uniformly…2019 American Transplant Congress
Calcineurin Inhibitors and Long-Term Outcomes of Kidney Transplantation from Thai Transplant Registry
Chulalongkorn University, Bangkok, Thailand
*Purpose: Calcineurin inhibitors (CNIs) have became the primary immunosuppressive medications (IS) for kidney transplantation (KT) in the current era. However, the long-term outcomes of KT…2019 American Transplant Congress
Renal Failure as a Complication of Vascularized Composite Allotransplantation
*Purpose: Vascularized composite allotransplantation (VCA) has demonstrated impressive outcomes in areas of extremity (UETx), face (FTx), genitourinary, and abdominal wall transplantation with up to twenty…2019 American Transplant Congress
The Impact of Early Subtherapeutic Tacrolimus Troughs with Alemtuzumab Induction
1Tampa General Hospital, Tampa, FL, 2Florida Kidney Physicians, Tampa, FL
*Purpose: Prior studies in kidney transplant recipients (KTR) have demonstrated that lower tacrolimus (TAC) exposure during the first week is associated with an increased incidence…2019 American Transplant Congress
Long Term Renal Function Following Islet Transplantation in the Clinical Islet Transplantation Consortium
*Purpose: Islet transplantation (IsletTp) is safe and effective treatment of Type 1 diabetes complicated by severe hypoglycemia (Diabetes Care 2016, 39:1230). But the requirement for…2019 American Transplant Congress
Alterations in Cerebral Blood Flow before and after Kidney Transplantation
*Purpose: End stage renal disease (ESRD) is associated with alterations in cerebral blood flow (CBF) likely secondary to disrupted cerebral autoregulation. In this study we…2019 American Transplant Congress
Dual Treatment of CD40 Silencing or Mesenchymal Stem Cells Infusion with Sub-Therapeutic Doses of Cyclosporine Effectively Prevents Acute Rejection in an Allogenic Model of Renal Transplantation
*Purpose: This study was designed to investigate the combination of CD40 silencing or MSC infusion with suboptimal doses of Cyclosporine in this renal allograft model.*Methods:…
- « Previous Page
- 1
- …
- 5
- 6
- 7
- 8
- 9
- …
- 16
- Next Page »