ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Calcineurin"

  • 2022 American Transplant Congress

    Tacrolimus Induces Dedifferentiation of Pancreatic Beta Cells by Inhibition of Calcineurin/NFATc2 and Islet Cell Differentiation Genes

    C. M. Darden1, S. Vasu2, J. Mattke3, Y. Liu2, B. Naziruddin4, M. C. Lawrence2

    1Baylor University, Dallas, TX, 2Baylor University Medical Center, Dallas, TX, 3Baylor University, Waco, TX, 4Baylor University Medical Ctr, Dallas, TX

    *Purpose: Tacrolimus (FK506) is a potent immunosuppressant widely used for solid organ transplantation to prevent lymphokine gene expression by inhibiting calcineurin (CN) and its downstream…
  • 2022 American Transplant Congress

    Long-Term Low-Dose Corticosteroid Therapy Can Suppress Calcineurin Inhibitor Induced Nephrotoxicity without Steroid-Related Complication in Living Kidney Transplant Recipient

    H. Sasaki, H. Harada, D. Takamoto, Y. Takada, S. Harada, H. Tanaka

    Sapporo City General Hospital, Sapporo, Japan

    *Purpose: The induction of calcineurin inhibitors (CNI) greatly reduced the rate of allograft rejection, although their chronic use resulted in vascular inflammation in kidney transplant…
  • 2022 American Transplant Congress

    Post Transplant Virologic Outcomes in DCD Kidney Transplant Recipients Treated with Thymoglobulin Induction Immunosuppression and Maintenance Belatacept vs Calcineurin Inhibitor Therapy

    T. Engebretsen1, M. Kueht1, A. Lea2, M. Mujtaba3

    1Abdominal Transplant Surgery, University of Texas Medical Branch, Galveston, TX, 2Infectious Disease, University of Texas Medical Branch, Galveston, TX, 3Nephrology, University of Texas Medical Branch, Galveston, TX

    *Purpose: Belatacept is an inhibitor of the T-Cell costimulatory pathway that can be used in recipients of Donation after Circulatory Death (DCD) where the intended…
  • 2022 American Transplant Congress

    Pediatric Liver Transplant Factors That Influence Tacrolimus Absorption

    M. Chandran1, D. Yoeli1, A. Sater2, F. Karrer1, M. Adams1

    1Children's Hospital Colorado, Aurora, CO, 2University of Colorado, Aurora, CO

    *Purpose: The aim of this study was to investigate the association between various pediatric recipient characteristics at time of liver transplant and FK506 absorption 6…
  • 2022 American Transplant Congress

    Impact of Biliary Reconstruction on Tacrolimus Absorption in Pediatric Liver Transplant

    M. Chandran1, D. Yoeli1, A. Sater2, M. Adams1, F. Karrer1

    1Children's Hospital Colorado, Aurora, CO, 2University of Colorado, Aurora, CO

    *Purpose: Tacrolimus (FK506) oral bioavailability in pediatric liver transplant recipients (LTR) is poor. Enteral FK506 is primarily absorbed in the small intestine and subject to…
  • 2022 American Transplant Congress

    Post-Kidney Transplant Dementia Risk by Modifiable Risk Factors and CNIs Among Older Recipients

    Y. Chen1, J. Ahn1, N. Chu1, S. Bae1, M. A. Schnitzler2, G. Hess3, K. Lentine4, D. Segev5, M. McAdams-DeMarco1

    1Johns Hopkins School of Medicine, Baltimore, MD, 2Surgery, Saint Louis University, O Fallon, IL, 3Drexel University School of Medicine, Philadelphia, PA, 4Saint Louis University, St. Louis, MO, 5Johns Hopkins University, Baltimore, MD

    *Purpose: Up to 17% of older recipients develop dementia after kidney transplant (KT). While there are known modifiable risk factors for dementia among community-dwelling older…
  • 2022 American Transplant Congress

    Evaluation of Different Initial Tacrolimus Dosing Regimens in Pediatric Post-Liver Transplantation

    A. F. Alghanem1, A. Alsmari1, H. Joharji2

    1Pharmaceutical Care, King Abdulaziz Medical City, Riyadh, Saudi Arabia, 2Pharmaceutical Care, King Faisal Specialized Hospital and Research Center, Riyadh, Saudi Arabia

    *Purpose: Tacrolimus is an immunosuppressant used in post-liver transplantation, has wide pharmacokinetic variability, particularly in pediatric patients. Therefore, this study aimed to evaluate different weight-based…
  • 2022 American Transplant Congress

    Long-Term Outcomes After Conversion to a Belatacept-Based Immunosuppression in Kidney Transplant: A Matched Cohort Study

    G. Divard, C. Debiais, C. Legendre, O. Aubert, C. Lefaucheur, A. Loupy

    Paris Transplant Group, INSERM, Paris, France

    *Purpose: Conversion to belatacept after transplant seems to be safe. However, no studies have reported the long-term efficacy and safety outcomes after conversion to belatacept…
  • 2022 American Transplant Congress

    Predicted Performance of Bayesian-Based Precision Dosing Software for Tacrolimus

    A. Seghezzo1, J. Kerr1, A. Gupta2, A. Ta2, L. Powell2, A. Feist3

    1University of California San Diego Health, San Diego, CA, 2PrecisePK, San Diego, CA, 3UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, CA

    *Purpose: Bayesian-based precision dosing software (BPDS) has been utilized for therapeutic drug monitoring to optimize medication use. However, BPDS for tacrolimus (TAC) is not routinely…
  • 2022 American Transplant Congress

    Conversion to Everolimus-Based Immunosuppression Regimen with Calcineurin Inhibitor Reduction Ameliorates Histological Damage in Kidney Transplant Recipients with Calcineurin Inhibitor-Induced Nephrotoxicity

    K. Hotta, N. Iwahara, T. Tanabe, N. Shinohara

    Hokkaido University Hospital, Sapporo, Japan

    *Purpose: In the last two decades, the short-term results for kidney transplantation (KTX) have improved owing to the use of calcineurin inhibitors (CNIs). However, long-term…
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