2022 American Transplant Congress
Urinary Cell CTOT-04 Signature is Diagnostic of Glomerulitis in Kidney Allograft Biopsies
1Nephrology, Weill Cornell-NYPH, New York, NY, 2Pathology, Weill Cornell-NYPH, New York, NY
*Purpose: Antibody mediated rejection is a significant complication after kidney transplantation and is an important cause of allograft failure. In the multicenter CTOT-04 study, we…2022 American Transplant Congress
Histologic Predictors of Graft Loss in Early Clinically Indicated Biopsies After Kidney Transplantation
*Purpose: We aimed to investigate histopathological predictors of graft lost in patients who underwent clinically indicated biopsies for worsening kidney function and/or proteinuria within 3…2022 American Transplant Congress
Unravelling the Stage-Shift of Acute Rejection by Urine QSant
1Nephrosant, Brisbane, CA, 2NephroSant, Brisbane, CA
*Purpose: Suboptimal performance in current methods for allograft monitoring underscores the unmet need for enhanced immunosurveillance accuracy, to uncover the alloimmunity flux. QSant[Yang et al,…2022 American Transplant Congress
Poor Outcomes in Patients with Transplant Glomerulopathy Independent of Banff Categorization or Therapeutic Interventions
*Purpose: Banff classification is an accepted diagnostic tool, but also used as a tool to define endpoints in clinical trials. There is a need to…2022 American Transplant Congress
A Comparison of Vibration Controlled Transient Elastography, FAST, AGILE-3 and AGILE-4 Scores in Liver Transplant Recipients
*Purpose: Hepatic fibrosis is a strong predictor of clinical outcomes following liver transplantation (LT), however, non-invasive fibrosis assessment remains challenging. Vibration controlled transient elastography has…2022 American Transplant Congress
Novel Biopsy-Based Clinical Phenotype Clustering to Predict Kidney Transplant Outcomes
*Purpose: The purpose of this study was to define novel clinical phenotypes based on biopsy results to enhance biomarker discovery.*Methods: Retrospective analysis of kidney biopsy…2022 American Transplant Congress
Antibody-Mediated Kidney Allograft Rejection (ABMR) Monitoring and Intervention Based on ABMR Subtypes – A Step Towards Precision Diagnosis and Management
*Purpose: The monitoring of kidney allograft for early detection of antibody mediated rejection (ABMR) and subsequent intervention using traditional clinical parameters has been insufficient due…2022 American Transplant Congress
De Novo Anti-Brush Border Antibody Disease in a Kidney Transplant Recipient
Ohio State University, Columbus, OH
*Purpose: Anti-brush border antibody (ABBA) disease is very rare, characterized by tubulointerstitial damage caused by autoantibodies against LDL receptor-related protein 2 (LRP2) in the proximal…2022 American Transplant Congress
Microvascular Inflammation in Kidney Transplant Biopsies in the Absence of HLA-DSA Displays Intense Cytotoxic T-cell and NK Cell but Not Plasma Cell Infiltration
*Purpose: Microvascular inflammation (MVI) without evidence of HLA-donor-specific antibodies (HLA-DSA) or C4d+ deposition remains an enigmatic phenotype, which cannot be classified as antibody-mediated rejection (ABMR)…2022 American Transplant Congress
Concordance of Kidney and Pancreas Rejection on Protocol and for Cause Biopsy in Simultaneous Kidney Pancreas Transplantation
*Purpose: Our aim was to study the concordance rate of kidney and pancreas rejection in patients who received simultaneous kidney-pancreas transplantation (SKP) and its effects…
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