2022 American Transplant Congress
A Novel Approach to Non-Invasive Multimodality Testing with Allosure and Allomap Predicts Microvascular Inflammation with High Accuracy in Kidney Transplant Recipients
University of Wisconsin, Madison, WI
*Purpose: The most prominent histologic lesion in antibody-mediated rejection (ABMR) is microvascular inflammation (MVI); however, its recognition and scoring can be challenging and poorly reproducible…2022 American Transplant Congress
The Correlation Between Kidney Donor Risk Index, Kidney Graft Function and Histological Changes in Early Post-Transplant Renal Biopsy
*Purpose: An appropriate assessment of donor organ quality is crucial to optimize the kidney allocation and improve the long-term outcomes. Kidney Donor Risk Index (KDRI),…2022 American Transplant Congress
Molecular Associations in Kidney Transplant Biopsies in the Trifecta Study Indicate That at Least Three Distinct Processes Release Dd-cfDNA: ABMR, TCMR, and Injury
*Purpose: In the Trifecta study (ClinicalTrials.gov # NCT04239703 53), elevated plasma dd-cfDNA is associated with molecular rejection in kidney transplant indication biopsies, particularly active ABMR…2022 American Transplant Congress
Deep-Learning Based Pathological Assessment of Frozen Procurement Kidney Biopsies
*Purpose: Organ shortage in kidney transplantation is a major issue for ESKD individuals on the waiting list. Sclerotic glomeruli or interstitial fibrosis on procurement donor…2022 American Transplant Congress
Histologic Borderline Reflects Molecular Injury Not Rejection: Results from the Trifecta Study
*Purpose: In the Trifecta study (NCT04239703), we recently compared indication biopsy diagnoses (MMDx and histology) and plasma %dd-cfDNA levels for indication biopsies (JASN in press…2022 American Transplant Congress
Reassessment of Previous Kidney Discards from a Single Large Organ Procurement Organization
1David Geffen School of Medicine, Los Angeles, CA, 2One Legacy, Los Angeles, CA
*Purpose: After deceased donor kidneys are recovered, they are offered according to UNOS policy and are discarded if no centers in the country would use…2022 American Transplant Congress
The Relative Association of Clinical Variables and Histologic Lesions with Molecular Rejection in Kidney Transplant Biopsies
*Purpose: Availability of molecular assessment (MMDx) independent of conventional variables (time, clinical, histologic, and HLA antibody) presents an opportunity to re-assess the relative strength of…2022 American Transplant Congress
The Ontario Anatomic Kidney Score (OAKS) : Quantitative Macroscopic Assessment versus Histological Grading in Pre-transplant Evaluation of Donor Kidneys
*Purpose: Quantitative gross assessment of a kidney has not been used to influence the evaluation to utilize a kidney for transplantation. The Ontario Anatomic Kidney…2022 American Transplant Congress
Treading the Paradigm Shift: A Single Center Comparative Study of Outcomes Between Pre-Emptive and Early Kidney Transplant with Non Pre-Emptive Kidney Transplant Recipients Innational Kidney and Transplant Institute
*Purpose: To compare the 3-year outcome of pre-emptive and early kidney transplant recipients versus non pre-emptive recipients in our institution from January 2013 to December…2022 American Transplant Congress
Biopsy Characteristics of Kidneys from a Single Large OPO
1David Geffen School of Medicine, Los Angeles, CA, 2One Legacy, Los Angeles, CA
*Purpose: As deceased donor pool have expanded, kidney biopsy has been increasingly used to help determine organ suitability for transplant. There are concerns that biopsy…
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