2022 American Transplant Congress
Deceased Donor Procurement Biopsy Practices, Interpretation, and Histology-Based Decision Making: A Survey of US Transplant Centers
*Purpose: In light of contemporary controversies on the utility of kidney procurement biopsies in predicting allograft outcomes and guiding organ acceptance, we surveyed transplant providers…2022 American Transplant Congress
Surveillance with Protocol Biopsies for Rejection Significantly Impacts Survival Following Intestine Transplant
*Purpose: Frequent surveillance biopsy is required on the first month post intestinal transplant(IT) due to high-risk of acute rejection. However, the utility and the frequency…2022 American Transplant Congress
Using a Unique Repository of Pancreas Transplant Biopsies to Validate the Tissue Common Response Module (tCRM) Score as a Tool to Assess the Severity of Pancreas Transplant Rejection
*Purpose: Analysis of transcriptional data from kidney, heart, liver, and lung transplant rejection led to development of the tissue Common Response Module (tCRM) score based…2022 American Transplant Congress
The Prediction of Renal Allograft Rejection by Time-Dependent Two-Signature Predictors
*Purpose: The study aims to develop RNA signature predictors using preemptive biopsy transcriptome data to predict future allograft rejection and reveal the predictors' time-dependent features.*Methods:…2022 American Transplant Congress
Rapid Formalin-Fixed Deceased Donor Kidney Biopsy Protocol – A Proof Of Concept
*Purpose: Reducing kidney discard is a major priority for the transplant community. While frozen section biopsies are the current standard, they are fraught with technical…2022 American Transplant Congress
Temporal Changes in the Peripheral Immune Profile of Acute Rejection Highlight New Mechanisms of Alloimmunity and Potential Non-Invasive Biomarkers of Rejection in Pediatric Liver Transplantation
*Purpose: Acute rejection (AR) is common in pediatric liver transplantation (LT) and can impact late graft loss. Immune subpopulations mediating AR in LT have not…2022 American Transplant Congress
Novel Avenue of Allograft Monitoring: Direct Measurement of Donor-Derived Extracellular Vesicles in Human Plasma
Internal Medicine, Erasmus MC Transplant Institute, Rotterdam, Netherlands
*Purpose: Extracellular Vesicles (EV) - regarded as “snapshots” of their cell of origin - represent promising liquid biomarkers to monitor allograft function post transplantation. Recently,…2022 American Transplant Congress
Deep Learning Identifies Arterial Intimal Fibrosis in Kidney Transplant Biopsies
*Purpose: Arterial intimal fibrosis (AIF) is the excessive fibrotic tissue formation in the intima of arteries indicative of poor graft function after kidney transplant. Visual…2022 American Transplant Congress
Role of Circulating Tumour Cells in the Management of the Liver Transplant Patient with Hepatocellular Carcinoma
*Purpose: For hepatocellular carcinoma (HCC), liver transplantation (LT) is considered a curative treatment, however, more than 10% of transplant recipients have recurrences within the first…2022 American Transplant Congress
Deep Phenotyping Methods Highlight Recipient-Derived CD16+ NK and CD16+ Monocyte Infiltration During Kidney Transplant Rejection
*Purpose: How the immune system participates to kidney transplant rejection has not been fully elucidated. Single-cell (sc) genomics techniques are revolutionizing our ability to characterize…
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