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Articles tagged "Biopsy"

  • 2015 American Transplant Congress

    A Prospective Comparison of the Completeness of Donor Kidney Biopsies

    S. Ahmad,1 E. Siskind,1 C. Drachenberg,2 J. Bromberg,1 S. Niederhaus.1

    1Transplantation, University of Maryland, Baltimore; 2Pathology, University of Maryland, Baltimore.

    Background: The use of expanded criteria kidneys has plateaued, possibly due to inadequate pathologic evaluation or lack of a universal grading system. We examined pre-transplant…
  • 2015 American Transplant Congress

    Blood Gene Expression at 3 Months Post-Transplantation Predicts 1-Year Histological Features in Renal Transplantation

    R. Danger,1,2 K. Renaudin,1,3,4 C. Paul,1 G. Couvrat-Desvergnes,1,3 J. Lozano,5 A. Sanchez-Fueyo,2,5 V. Meas-Yedid,6 J. Olivo-Marin,6 E. Thervet,7 J. Dantal,1,3,4 A. Moreau,1,3,4 J.-P. Duong Van Huyen,8 J.-P. Soulillou,1,3,4 M. Giral,1,3,4 S. Brouard.1,3,4

    1INSERM U1064 and ITUN, Nantes, France; 2Department of Liver Sciences, Faculty of Life Sciences & Medicine, MRC Transplant Centre, King's College London, London, United Kingdom; 3Centre Hospitalier Universitaire Hôtel-Dieu, Nantes, France; 4Universite de Nantes, Nantes, France; 5Liver Unit and Bioinformatic Platform, CIBEREHD, Hospital Clinic Barcelona, Barcelona, Spain; 6Unité d'Analyse d'Image Quantitative, Institut Pasteur, Paris, France; 7Nephrology Unit, Hôpital Européen Georges Pompidou, Paris, France; 8Service d'Anatomie Pathologique, Hôpital Européen Georges Pompidou, Paris, France.

    Histological analysis of biopsy at one year is proposed as a reliable tool for assessing renal allograft status, however, a non-invasive method for early prediction…
  • 2015 American Transplant Congress

    Clinicopathological Scenarios (CPS) Defined by Viremia, Creatinine and Histology in Polyomavirus Nephropathy Differ in 1st and 2nd (Follow-Up) Biopsy

    C. Drachenberg, M. Chaudhry, F. Yang, R. Ugarte, A. Haririan, M. Mavanur, C. Cangro, B. Thomas, N. Costa, E. Ramos, M. Weir, J. Papadimitriou.

    Pathology and Medicine, University of Maryland School of Medicine, Baltimore, MD.

    Studies of sequential kidney biopsies (KB) after the diagnosis of polyomavirus allograft nephropathy (PVN) are scarce and clinicopathological evolution of PVN poorly understood. In practice…
  • 2015 American Transplant Congress

    Differentially Expressed IL-6Rα and GP130 Genes in Kidney Biopsies (Bxs) Suggests Different Roles of IL-6 Signaling in Antibody (ABMR)- and Cell (CMR)-Mediated Rejection

    H. Zhang,1 D. Thomas,1 J. Kowalewska,2 E. Suviolahti,1 H. Shafi,2 C. Nast,2 A. Gertych,2 A. Vo,1 M. Haas,2 S. Jordan,1 M. Toyoda.1

    1Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; 2Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.

    Background: IL-6 exerts immunoregulatory properties through IL-6 receptors, IL-6Rα and gp130. Our previous studies suggested the involvement of antibody-dependent cellular cytotoxicity (ADCC) and its related…
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