ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Biopsy"

  • 2015 American Transplant Congress

    Hybrid Ostomy – New Technique in Intestinal Transplantation

    T. Beduschi, J. Garcia, P. Ruiz, A. Tekin, G. Selvaggi, S. Nishida, J. Fan, R. Vianna.

    Miami Transplant Institute, University of Miami Miller School of Medicine, Miami, FL.

    Introduction: Many experimental non-invasive methods have been tested to assess the intestinal graft, but none of them proved to be reliable. Biopsy of the intestine…
  • 2015 American Transplant Congress

    Explorative Analysis of ZEUS After 5 Years: Histological Assessment from Biopsy Analyses

    U. Eisenberger,1 K. Budde,1 O. Witzke,1 F. Lehner,1 C. Sommerer,1 R. Wuethrich,3 P. Reinke,1 A. Muehlfeld,1 K. Heller,1 R. Stahl,1 H. Wolters,1 I. Hauser,1 M. Porstner,2 W. Arns.1

    1ZEUS Study Group, Germany; 2Novartis, Pharma, Germany; 3ZEUS Study Group, Switzerland.

    Background: Analysis of pathologists' assessments and histological data allow for deeper insight on patient outcome together with investigator's final clinical diagnoses. Here we present 5…
  • 2015 American Transplant Congress

    De Novo DSA Would Not Necessarily Cause Graft Rejection After Renal Transplantation: Characteristics of DSA Developing Biopsy-Proven Chronic Antibody-Mediated Rejection

    T. Yamamoto, Y. Watarai, A. Takeda, M. Okada, M. Tsujita, H. Takahisa, N. Goto, S. Narumi, T. Kobayashi.

    Kidney Center, Nagoya Daini Red Cross Hospital, Nagoya, Japan.

    Introduction:De novo donor-specific HLA antibodies (dn DSA) production after renal transplantation has been reported to be associated with chronic antibody mediated rejection (CAMR), which leads…
  • 2015 American Transplant Congress

    A Single Center Study on Pregnacy and Allograf Function Outcomes Post Heart Transplant

    S. Adams, M. Wigger.

    Heart Transplant, Vanderbilt Medical Center, Nasvhille, TN.

    Pregnancy is a special time during a young woman's life, especially more so in those young women who are post heart transplant. The purpose of…
  • 2015 American Transplant Congress

    Reduction of Tacrolimus With Everolimus Addition in Maintenance Immunosuppression Improves Calcineurin Inhibitor-Induced Arteriolopathy in Kidney Allografts

    M. Miura,1 H. Higashiyama,1 Y. Fukasawa.2

    1Department of Renal Transplant Surgery, Sapporo Hokuyu Hospital, Sapporo, Japan; 2Department of Pathology, Sapporo City General Hospital, Sapporo, Japan.

    Objectives: Although conversion of calcineurin inhibitor (CNI)-based immunosuppression to everolimus (EVR) has been shown to improve graft function, no histopathological evidence has been reported. The…
  • 2015 American Transplant Congress

    Late Antibody-Mediated Rejection in a Large Cross-Sectional Cohort of Kidney Transplant Recipients – Results of the Screening Phase of the BORTEJECT Study

    F. Eskandary,1 G. Bond,1 H. Regele,2 N. Kozakowski,2 Z. Kikic,1 M. Wahrmann,1 H. Haslacher,3 R. Oberbauer,1 V. Ramassar,4 P. Halloran,4 G. Böhmig.1

    1Nephrology and Dialysis, Medical University Vienna, Vienna, Austria; 2Clinical Institute of Pathology, Medical University Vienna, Vienna, Austria; 3Department of Laboratory Medicine, Medical University Vienna, Vienna, Austria; 44Division of Nephrology and Transplant Immunology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.

    Antibody-mediated rejection (ABMR) is well established to be a leading cause of graft failure. Here, we investigated the prevalence of late ABMR in a large…
  • 2015 American Transplant Congress

    Mitochondrial Feedback Mechanisms in Kidney Cell Senescence

    K. De Vusser,1 K. Hochstenbach,2 E. Winckelmans,2 E. Lerut,3 D. Kuypers,1 T. Nawrot,2 M. Naesens.1

    1Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium; 2Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium; 3Department of Pathology, University Hospitals Leuven, Leuven, Belgium.

    BackgroundProgressive DNA damage (telomere attrition) is considered one of the key instigators of ageing. Different models for ageing where DNA damage leads to accelerated senescence…
  • 2015 American Transplant Congress

    Prognostic Relevance of Rejection Episodes Detected Within the First 3 Weeks After Kidney Transplantation

    V. Arelin,1 H. Schrem,2 F. Lehner,2 W. Gwinner,1 H. Haller,1 M. Schiffer.1

    1Division of Nephrology and Hypertension, Department of Medicine, Hannover Medical School, Hannover, Lower Saxony, Germany; 2General, Visceral and Transplant Surgery, Hannover Medical School, Hannover, Lower Saxony, Germany.

    Background:The relevance of cellular rejection events detected in the early phase after kidney transplantation for graft survival and function remains to be elucidated. Especially the…
  • 2015 American Transplant Congress

    Distinct Blood and Biopsy Meta-Signatures for Acute Rejection Post Kidney Transplant

    W. Zhang,1 Z. Yi,1 Z. Li,1 M. Menon,1 L. Li,1 C. Xi,1 I. Greene,1 C. Wei,1 L. Gallon,2 M. Samaniego,3 A. Djamali,4 S. Alexander,5 B. Schroppel,1 B. Nankivell,5 J. Chapman,5 I. Rosales,6 R. Neal Smith,6 R. Colvin,6 P. O'Connell,5 P. Heeger,1 B. Murphy.1

    1Icahn School of Medicine at Mount Sinai, New York; 2North Western University, Chicago; 3University of Michigan, Michigan; 4University of Wisconsin, Madison; 5The University of Sydney, Sydney, Austria; 6Massachusetts General Hospital, Boston.

    Acute rejection (AR) is a major cause of allograft dysfunction. Molecular signatures of AR from blood and biopsy have been identified by several independent cohort…
  • 2015 American Transplant Congress

    Inflammation in Regions of Tubular Atrophy (IATR) Predicts Adverse Graft Outcome in Patients With Late Graft Dysfunction: A Multicenter Study

    J. Grande,1 R. Leduc,3 A. Matas.2

    1Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN; 2Surgery, University of Minnesota, Minneapolis, MN; 3Biostatistics, University of Minnesota, Minneapolis, MN.

    Purpose: Inflammation in regions of tubular atrophy (IATR) is a risk factor for late graft loss. However, IATR is associated with inflammation in non-atrophic regions…
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